Division of labour in ESCRT complexes (original) (raw)

Nature Cell Biology volume 12, pages 422–423 (2010)Cite this article

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Formation of multivesicular bodies (MVBs) from endosomes or budding of enveloped virus such as HIV-I from the plasma membrane require the ESCRT (endosomal sorting complex required for transport) complexes. An in vitro reconstitution assay unambiguously identifies the function of each ESCRT complex in the sequential events of MVB morphogenesis, from cargo clustering and membrane bud formation to sequestration of cargoes in vesicles, and fission of the vesicles into the lumen of the endosome.

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Figure 1: Schematic representation of the sequence leading to intralumenal vesicle (ILV) morphogenesis by ESCRT complexes.

References

  1. Antonny, B. Curr. Opin. Cell Biol. 18, 386–394 (2006).
    Article CAS Google Scholar
  2. Römer, W. et al. Nature 450, 670–675 (2007).
    Article Google Scholar
  3. McMahon, H. T. & Gallop, J. L. Nature 438, 590–596 (2005).
    Article CAS Google Scholar
  4. Zimmerberg, J. & Kozlov, M. M. Nat. Rev. Mol. Cell Biol. 7, 9–19 (2006).
    Article CAS Google Scholar
  5. Roux, A.l., Uyhazi, K., Frost, A. & De Camilli, P. Nature 441, 528–531 (2006).
    Article CAS Google Scholar
  6. Bashkirov, P. V. et al. Cell 135, 1276–1286 (2008).
    Article CAS Google Scholar
  7. Gruenberg, J. & Stenmark, H. Nat. Rev. Mol. Cell Biol. 5, 317–324 (2004).
    Article CAS Google Scholar
  8. Hurley, J. H. & Emr, S. D. Annu. Rev. Biophys. Biomol. Struct. 35, 277–298 (2006).
    Article CAS Google Scholar
  9. Wollert, T. & Hurley, J. H. Nature 464, 864–869 (2010).
    Article CAS Google Scholar
  10. Wollert, T., Wunder, C., Lippincott-Schwartz, J. & Hurley, J. H. Nature 458, 172–177 (2009).
    Article CAS Google Scholar
  11. Katzmann, D. J., Stefan, C. J., Babst, M. & Emr, S. D. J. Cell Biol. 162, 413–423 (2003).
    Article CAS Google Scholar
  12. Gill, D. J. et al. EMBO J. 26, 600–612 (2007).
    Article CAS Google Scholar
  13. Hanson, P. I., Roth, R., Lin, Y. & Heuser, J. E. J. Cell Biol. 180, 389–402 (2008).
    Article CAS Google Scholar
  14. Lata, S. et al. Science 321, 1354–1357 (2008).
    Article CAS Google Scholar
  15. Lenz, M., Crow, D. J. G. & Joanny, J.-F. Phys. Rev. Lett. 103, 038101–038104 (2009).
    Article Google Scholar
  16. Manneville, J.-B. et al. Proc. Natl. Acad. Sci. USA 105, 16946–16951 (2008).
    Article CAS Google Scholar
  17. Fabrikant, G. et al. PLoS Comput. Biol. 5, e1000575 (2009).
    Article Google Scholar

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  1. Patricia Bassereau is in the Laboratoire PhysicoChimie Curie, Institut Curie, F-75248 Paris Cedex 05, France. patricia.bassereau@curie.fr,
    Patricia Bassereau

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  1. Patricia Bassereau
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Bassereau, P. Division of labour in ESCRT complexes.Nat Cell Biol 12, 422–423 (2010). https://doi.org/10.1038/ncb0510-422

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