Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization (original) (raw)

References

  1. Slusarski, D.C., Corces, V.G. & Moon, R.T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390, 410–413 (1997).
    Article CAS Google Scholar
  2. Sumanas, S. & Ekker, S.C. Xenopus frizzled-7 morphant displays defects in dorsoventral patterning and convergent extension movements during gastrulation. Genesis 30, 119–122 (2001).
    Article CAS Google Scholar
  3. Winklbauer, R., Medina, A., Swain, R.K. & Steinbeisser, H. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 413, 856–860 (2001).
    Article CAS Google Scholar
  4. Kuhl, M., Sheldahl, L.C., Park, M., Miller, J.R. & Moon, R.T. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16, 279–283 (2000).
    Article CAS Google Scholar
  5. Salahpour, A., Angers, S. & Bouvier, M. Functional significance of oligomerization of G-protein-coupled receptors. Trends Endocrinol. Metab. 11, 163–168 (2000).
    Article CAS Google Scholar
  6. Angers, S., Salahpour, A. & Bouvier, M. Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu. Rev. Pharmacol. Toxicol. 42, 409–435 (2002).
    Article CAS Google Scholar
  7. Rios, C.D., Jordan, B.A., Gomes, I. & Devi, L.A. G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol. Ther. 92, 71–87 (2001).
    Article CAS Google Scholar
  8. Robitaille, J. et al. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nature Genet. 32, 326–330 (2002).
    Article CAS Google Scholar
  9. Rossi, F.M., Blakely, B.T., Charlton, C.A. & Blau, H.M. Monitoring protein-protein interactions in live mammalian cells by beta-galactosidase complementation. Methods Enzymol. 328, 231–251 (2000).
    Article CAS Google Scholar
  10. Rossi, F., Charlton, C.A. & Blau, H.M. Monitoring protein–protein interactions in intact eukaryotic cells by β-galactosidase complementation. Proc. Natl Acad. Sci. USA 94, 8405–8410 (1997).
    Article CAS Google Scholar
  11. Mercier, J.F., Salahpour, A., Angers, S., Breit, A. & Bouvier, M. Quantitative assessment of β1- and β2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J. Biol. Chem. 277, 44925–44931 (2002).
    Article CAS Google Scholar
  12. Schlessinger, J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110, 669–672 (2002).
    Article CAS Google Scholar
  13. Dann, C.E. et al. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412, 86–90 (2001).
    Article CAS Google Scholar
  14. Bafico, A. et al. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J. Biol. Chem. 274, 16180–16187 (1999).
    Article CAS Google Scholar
  15. Carron, C. et al. Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway. J. Cell Sci. 116, 2541–2550 (2003).
    Article CAS Google Scholar
  16. Zhang, Z., Sun, S., Quinn, S.J., Brown, E.M. & Bai, M. The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions. J. Biol. Chem. 276, 5316–5322 (2001).
    Article CAS Google Scholar
  17. Rivera, V.M. et al. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287, 826–830 (2000).
    Article CAS Google Scholar
  18. Ou, W. & Silver, J. Role of a conserved amino-terminal sequence in the ecotropic MLV receptor mCAT1. Virology 308, 101–113 (2003).
    Article CAS Google Scholar
  19. Sheldahl, L.C., Park, M., Malbon, C.C. & Moon, R.T. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol. 9, 695–698 (1999).
    Article CAS Google Scholar
  20. Kuhl, M., Sheldahl, L.C., Malbon, C.C. & Moon, R.T. Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275, 12701–12711 (2000).
    Article CAS Google Scholar
  21. Gomes, I. et al. G protein coupled receptor dimerization: implications in modulating receptor function. J. Mol. Med. 79, 226–242 (2001).
    Article CAS Google Scholar
  22. Goodwin, A.M. & D'Amore, P.A. Wnt signaling in the vasculature. Angiogenesis 5, 1–9 (2002).
    Article CAS Google Scholar
  23. Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H. & Moon, R.T. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13, 680–685 (2003).
    Article CAS Google Scholar

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