Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition (original) (raw)

• Schulze-Bergkamen, H. & Krammer, P. H. Apoptosis in cancer-implications for therapy. Semin. Oncol. 31, 90–119 (2004).
  Article CAS Google Scholar
• Kumar, R., Vadlamudi, R. K. & Adam, L. Apoptosis in mammary gland and cancer. Endocr. Relat. Cancer 7, 257–269 (2000).
  Article CAS Google Scholar
• Chapman, R. S. et al. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev. 13, 2604–2616 (1999).
  Article CAS Google Scholar
• Schwertfeger, K. L., Richert, M. M. & Anderson, S. M. Mammary gland involution is delayed by activated Akt in transgenic mice. Mol. Endocrinol. 15, 867–881 (2001).
  Article CAS Google Scholar
• Franke, T. F. et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 2, 727–736 (1995).
  Article Google Scholar
• Levy, D. E. & Darnell, J. E. Jr. Stats: transcriptional control and biological impact. Nature Rev. Mol. Cell Biol. 3, 651–662 (2002).
  Article CAS Google Scholar
• Kritikou, E. A. et al. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development 130, 3459–3468 (2003).
  Article CAS Google Scholar
• Yu, H. & Jove, R. The STATs of cancer - new molecular targets come of age. Nature Rev. Cancer 4, 97–105 (2004).
  Article CAS Google Scholar
• Stambolic, V. et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29–39 (1998).
  Article CAS Google Scholar
• Otsu, M. et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell 65, 91–104 (1991).
  Article CAS Google Scholar
• Pons, S. et al. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol. Cell Biol. 15, 4453–4465 (1995).
  Article CAS Google Scholar
• Antonetti, D. A., Algenstaedt, P. & Kahn, C. R. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell Biol. 16, 2195–2203 (1996).
  Article CAS Google Scholar
• Inukai, K. et al. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85 gene. J. Biol. Chem. 271, 5317–5320 (1996).
  Article CAS Google Scholar
• Fruman, D. A., Cantley, L. C. & Carpenter, C. L. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics 37, 113–121 (1996).
  Article CAS Google Scholar
• Inukai, K. et al. p85 gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50, p55, and p85, with different PI 3-kinase activity elevating responses to insulin. J. Biol. Chem. 272, 7873–7882 (1997).
  Article CAS Google Scholar
• Vanhaesebroeck, B., Leevers, S. J., Panayotou, G. & Waterfield, M. D. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22, 267–272 (1997).
  Article CAS Google Scholar
• Cantley, L. C. The phosphoinositide 3-kinase pathway. Science 296, 1655–1657 (2002).
  Article CAS Google Scholar
• Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F. & Kahn, C. R. Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85 regulatory subunit. Mol. Cell Biol. 20, 8035–8046 (2000).
  Article CAS Google Scholar
• Ueki, K. et al. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol. Cell Biol. 22, 965–977 (2002).
  Article CAS Google Scholar
• Inukai, K. et al. Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. FEBS Lett. 490, 32–38 (2001).
  Article CAS Google Scholar
• O'Farrell, A. M., Liu, Y., Moore, K. W. & Mui, A. L. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 16, 1006–1018 (1998).
  Article Google Scholar
• Leaman, D. W. et al. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol. Cell Biol. 16, 369–375 (1996).
  Article CAS Google Scholar
• Niwa, H., Burdon, T., Chambers, I. & Smith, A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12, 2048–2060 (1998).
  Article CAS Google Scholar
• Burdon, T., Smith, A. & Savatier, P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12, 432–438 (2002).
  Article CAS Google Scholar
• Hallmann, D. et al. Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85. J. Biol. Chem. 278, 5099–5108 (2003).
  Article CAS Google Scholar
• Kerouz, N. J., Horsch, D., Pons, S. & Kahn, C. R. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J. Clin. Invest. 100, 3164–3172 (1997).
  Article CAS Google Scholar
• Torbenson, M. et al. STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. Am. J. Pathol. 161, 155–161 (2002).
  Article CAS Google Scholar
• Dani, C. et al. Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dev. Biol. 203, 149–162 (1998).
  Article CAS Google Scholar
• Vanhaesebroeck, B. et al. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nature Cell Biol. 1, 69–71 (1999).
  Article CAS Google Scholar
• Davuluri, R. V., Grosse, I. & Zhang, M. Q. Computational identification of promoters and first exons in the human genome. Nature Genet. 4, 412–417 (2001). Erratum in Nature Genet. 3, 459 (2002).
  Article Google Scholar