A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages (original) (raw)

• Huber, M. A., Kraut, N. & Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548–558 (2005).
  Article CAS PubMed Google Scholar
• Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871–890 (2009).
  Article CAS PubMed Google Scholar
• Guo, W. et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148, 1015–1028 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704–715 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Morel, A. P. et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS ONE 3, e2888 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Buck, E. et al. Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition. Mol. Cancer Ther. 6, 532–541 (2007).
  Article CAS PubMed Google Scholar
• Creighton, C. J. et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc. Natl Acad. Sci. USA 106, 13820–13825 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Gupta, P. B. et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138, 645–659 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Li, H. J., Reinhardt, F., Herschman, H. R. & Weinberg, R. A. Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov. 2, 840–855 (2012).
  Article CAS PubMed Google Scholar
• Malanchi, I. et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481, 85–89 (2011).
  Article CAS PubMed Google Scholar
• Merlos-Suarez, A. et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 8, 511–524 (2011).
  Article CAS PubMed Google Scholar
• Wynn, T. A., Chawla, A. & Pollard, J. W. Macrophage biology in development, homeostasis and disease. Nature 496, 445–455 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Coussens, L. M., Zitvogel, L. & Palucka, A. K. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science 339, 286–291 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Gyorki, D. E., Asselin-Labat, M. L., Rooijen, N. v., Lindeman, G. J. & Visvader, J. E. Resident macrophages influence stem cell activity in the mammary gland. Breast Cancer Res. 11, R62 (2009).
  Article PubMed PubMed Central Google Scholar
• Elenbaas, B. et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 15, 50–65 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Ong, S. E. et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteom. 1, 376–386 (2002).
  Article CAS Google Scholar
• Udeshi, N. D. et al. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol. Cell. Proteomics 11, 148–159 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Barker, T. H. & Hagood, J. S. Getting a grip on Thy-1 signaling. Biochim. Biophys. Acta. 1793, 921–923 (2009).
  Article CAS PubMed Google Scholar
• Wetzel, A. et al. Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J. Immunol. 172, 3850–3859 (2004).
  Article CAS PubMed Google Scholar
• Lim, E. et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 12, R21 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Shipitsin, M. et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 11, 259–273 (2007).
  Article CAS PubMed Google Scholar
• Dontu, G. et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17, 1253–1270 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Tsuchiya, S. et al. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer 26, 171–176 (1980).
  Article CAS PubMed Google Scholar
• Donnenberg, V. S. et al. Localization of CD44 and CD90 positive cells to the invasive front of breast tumors. Cytometry B Clin. Cytom. 78, 287–301 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Donnenberg, A. D., Zimmerlin, L., Landreneau, R. J., Luketich, J. D. & Donnenberg, V. S. KIT (CD117) expression in a subset of non-small cell lung carcinoma (NSCLC) patients. PLoS ONE 7, 1–11 (2012).
  Article CAS Google Scholar
• Medrek, C., Ponten, F., Jirstrom, K. & Leandersson, K. The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer 12, 306 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Tsutsui, S. et al. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol. Rep. 14, 425–431 (2005).
  CAS PubMed Google Scholar
• Ch’ng, E. S., Tuan Sharif, S. E. & Jaafar, H. In human invasive breast ductal carcinoma, tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis. Virchows Arch. 462, 257–267 (2013).
  Article PubMed Google Scholar
• Qian, B. Z. & Pollard, J. W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39–51 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Murray, P. J. & Wynn, T. A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723–737 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Lin, E. Y., Nguyen, A. V., Russell, R. G. & Pollard, J. W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727–740 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Ohri, C. M., Shikotra, A., Green, R. H., Waller, D. A. & Bradding, P. The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC. PLoS ONE 6, e21874 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Gabrilovich, D. I., Ostrand-Rosenberg, S. & Bronte, V. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253–268 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Hartman, Z. C. et al. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res. (2013).
• Korkaya, H., Liu, S. & Wicha, M. S. Regulation of cancer stem cells by cytokine networks: attacking cancer’s inflammatory roots. Clin. Cancer Res. 17, 6125–6129 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Wyckoff, J. et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 64, 7022–7029 (2004).
  Article CAS PubMed Google Scholar
• Tam, W. L. et al. Protein Kinase C alpha is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 24, 347–364 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Thomson, S., Petti, F., Sujka-Kwok, I., Epstein, D. & Haley, J. D. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin. Exp. Metastasis 25, 843–854 (2008).
  Article CAS PubMed Google Scholar
• Gentile, A., Lazzari, L., Benvenuti, S., Trusolino, L. & Comoglio, P. M. Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res. 71, 3132–3141 (2011).
  Article CAS PubMed Google Scholar
• Pasquale, E. B. Eph receptors and ephrins in cancer: Bidirectional signalling and beyond. Nat. Rev. Cancer 10, 165–180 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Lamberto, I. et al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445, 47–56 (2012).
  Article CAS PubMed Google Scholar
• Zhou, L. et al. EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. J. Neurosci. 27, 5127–5138 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Griner, E. M. & Kazanietz, M. G. Protein kinase C and other diacylglycerol effectors in cancer. Nat. Rev. Cancer 7, 281–294 (2007).
  Article CAS PubMed Google Scholar
• Kalo, M. S. & Pasquale, E. B. Signal transfer by eph receptors. Cell Tissue Res. 298, 1–9 (1999).
  Article CAS PubMed Google Scholar
• Lu, Z. G., Liu, H., Yamaguchi, T., Miki, Y. & Yoshida, K. Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. Cancer Res. 69, 5927–5935 (2009).
  Article CAS PubMed Google Scholar
• Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H. & Kracht, M. Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 72, 847–855 (2002).
  CAS PubMed Google Scholar
• Sasaki, C. Y., Ghosh, P. & Longo, D. L. Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor. J. Biol. Chem. 286, 1093–1102 (2011).
  Article CAS PubMed Google Scholar
• Yoon, S. et al. NF-kappaB and STAT3 cooperatively induce IL6 in starved cancer cells. Oncogene. 31, 3467–3481 (2012).
  Article CAS PubMed Google Scholar
• Ryan, K. M., Ernst, M. K., Rice, N. R. & Vousden, K. H. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404, 892–897 (2000).
  Article CAS PubMed Google Scholar
• Li, S. et al. TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production. BMC Biol. 10, 73 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Gisina, A. M. et al. Detection of minor subpopulations of colorectal adenocarcinoma cells expressing cancer stem cell markers. Bull. Exp. Biol. Med. 151, 234–238 (2011).
  Article CAS PubMed Google Scholar
• He, J. et al. CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays. Mol. Cell. Proteomics 11, M111 010744 (2012).
  Article CAS PubMed Google Scholar
• Jiang, J. et al. Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype. Oncogene. 31, 671–682 (2012).
  Article CAS PubMed Google Scholar
• Yang, Z. F. et al. Significance of CD90 + cancer stem cells in human liver cancer. Cancer Cell 13, 153–166 (2008).
  Article CAS PubMed Google Scholar
• Oki, M. et al. Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers. World J. Gastroenterol. 14, 5650–5656 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Oshima, T. et al. Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer. Int. J. Oncol. 33, 573–577 (2008).
  CAS PubMed Google Scholar
• Binda, E. et al. The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell 22, 765–780 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Gyorffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123, 725–731 (2010).
  Article CAS PubMed Google Scholar
• Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335–348 (2005).
  Article CAS PubMed Google Scholar
• Yu, M. et al. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev. 23, 1737–1742 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Shibue, T. & Weinberg, R. A. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc. Natl Acad. Sci. USA 106, 10290–10295 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Tergaonkar, V., Pando, M., Vafa, O., Wahl, G. & Verma, I. p53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 1, 493–503 (2002).
  Article CAS PubMed Google Scholar
• Stewart, S. A. et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493–501 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Han, J. et al. Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature 463, 1096–1100 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70–78 (2009).
  Article CAS PubMed Google Scholar
• Hammond, S. L., Ham, R. G. & Stampfer, M. R. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc. Natl Acad. Sci. USA 81, 5435–5439 (1984).
  Article CAS PubMed PubMed Central Google Scholar
• Naba, A. et al. The matrisome: In silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell. Proteomics 11, M111 014647 (2012).
  Article CAS PubMed Google Scholar