Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (original) (raw)

References

1. Bieber, T. Atopic dermatitis. N. Engl. J. Med. 358, 1483–1494 (2008).
   Article CAS Google Scholar
2. Brown, S.J. & McLean, W.H.I. Eczema genetics: current state of knowledge and future goals. J. Invest. Dermatol. 129, 543–552 (2009).
   Article CAS Google Scholar
3. Morar, N., Willis-Owen, S.A.G., Moffatt, M.F. & Cookson, W.O. The genetics of atopic dermatitis. J. Allergy Clin. Immunol. 118, 24–34 (2006).
   Article CAS Google Scholar
4. Palmer, C.N.A. et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 38, 441–446 (2006).
   Article CAS Google Scholar
5. Rodríguez, E. et al. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J. Allergy Clin. Immunol. 123, 1361–1370 e7 (2009).
   Article Google Scholar
6. Esparza-Gordillo, J. et al. A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat. Genet. 41, 596–601 (2009).
   Article CAS Google Scholar
7. Sun, L.D. et al. Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat. Genet. 43, 690–694 (2011).
   Article CAS Google Scholar
8. Moffatt, M.F. et al. A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med. 363, 1211–1221 (2010).
   Article CAS Google Scholar
9. Li, B. et al. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development 132, 1463–1473 (2005).
   Article CAS Google Scholar
10. Nair, M. et al. Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J. Cell Biol. 173, 253–264 (2006).
    Article CAS Google Scholar
11. Dai, X. et al. The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Genes Dev. 12, 3452–3463 (1998).
    Article CAS Google Scholar
12. Kowanetz, M., Valcourt, U., Bergström, R., Heldin, C.H. & Moustakas, A. Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein. Mol. Cell. Biol. 24, 4241–4254 (2004).
    Article CAS Google Scholar
13. Li, B. et al. The LEF1/β-catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc. Natl. Acad. Sci. USA 99, 6064–6069 (2002).
    Article CAS Google Scholar
14. Owens, P., Han, G., Li, A.G. & Wang, X.J. The role of Smads in skin development. J. Invest. Dermatol. 128, 783–790 (2008).
    Article CAS Google Scholar
15. Widelitz, R.B. Wnt signaling in skin organogenesis. Organogenesis 4, 123–133 (2008).
    Article Google Scholar
16. Buschke, S. et al. A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes. Mol. Biol. Cell 22, 782–794 (2011).
    Article CAS Google Scholar
17. Maganga, R. et al. Secreted Frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis. Biochem. Biophys. Res. Commun. 377, 606–611 (2008).
    Article CAS Google Scholar
18. Romanowska, M. et al. Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS ONE 4, e5354 (2009).
    Article Google Scholar
19. Nica, A.C. et al. The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet. 7, e1002003 (2011).
    Article CAS Google Scholar
20. Apte, S.S. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J. Biol. Chem. 284, 31493–31497 (2009).
    Article CAS Google Scholar
21. Porter, S., Clark, I.M., Kevorkian, L. & Edwards, D.R. The ADAMTS metalloproteinases. Biochem. J. 386, 15–27 (2005).
    Article CAS Google Scholar
22. Pollard, T.D. The cytoskeleton, cellular motility and the reductionist agenda. Nature 422, 741–745 (2003).
    Article CAS Google Scholar
23. Pollard, T.D. & Borisy, G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453–465 (2003).
    Article CAS Google Scholar
24. Winder, S.J. Structural insights into actin-binding, branching and bundling proteins. Curr. Opin. Cell Biol. 15, 14–22 (2003).
    Article CAS Google Scholar
25. Goetz, S.C. & Anderson, K.V. The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet. 11, 331–344 (2010).
    Article CAS Google Scholar
26. Mosimann, C., Hausmann, G. & Basler, K. β-catenin hits chromatin: regulation of Wnt target gene activation. Nat. Rev. Mol. Cell Biol. 10, 276–286 (2009).
    Article CAS Google Scholar
27. Chang, M. et al. Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun. 9, 176–181 (2008).
    Article CAS Google Scholar
28. Nair, R.P. et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways. Nat. Genet. 41, 199–204 (2009).
    Article CAS Google Scholar
29. Li, Y. et al. The 5q31 variants associated with psoriasis and Crohn's disease are distinct. Hum. Mol. Genet. 17, 2978–2985 (2008).
    Article CAS Google Scholar
30. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661–678 (2007).
31. Weidinger, S. et al. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet. 4, e1000166 (2008).
    Article Google Scholar
32. Vercelli, D. Discovering susceptibility genes for asthma and allergy. Nat. Rev. Immunol. 8, 169–182 (2008).
    Article CAS Google Scholar
33. Kleinjan, D.A. & van Heyningen, V. Long-range control of gene expression: emerging mechanisms and disruption in disease. Am. J. Hum. Genet. 76, 8–32 (2005).
    Article CAS Google Scholar
34. Sproul, D., Gilbert, N. & Bickmore, W.A. The role of chromatin structure in regulating the expression of clustered genes. Nat. Rev. Genet. 6, 775–781 (2005).
    Article CAS Google Scholar
35. Holle, R., Happich, M., Löwel, H. & Wichmann, H.E. & MONICA/KORA Study Group. KORA—a research platform for population based health research. Gesundheitswesen 67 (suppl. 1), S19–S25 (2005).
    Article Google Scholar
36. Krawczak, M. et al. PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet. 9, 55–61 (2006).
    Google Scholar
37. Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904–909 (2006).
    Article CAS Google Scholar
38. Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).
    Article CAS Google Scholar

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Acknowledgements

The full list of acknowledgments for each study is provided in the Supplementary Note.

Author information

Author notes

1. Lavinia Paternoster, Marie Standl and Marjo-Riitta Jarvelin: These authors contributed equally to this work.
2. Joachim Heinrich, David M Evans and Stephan Weidinger: These authors jointly directed this work.

Authors and Affiliations

1. Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social & Community Medicine, University of Bristol, Bristol, UK
   Lavinia Paternoster, George Davey Smith, John P Kemp, Nicholas J Timpson & David M Evans
2. Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
   Marie Standl, H-Erich Wichmann, Carla M T Tiesler, Elisabeth Thiering & Joachim Heinrich
3. Department for Paediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
   Chih-Mei Chen
4. Respiratory Epidemiology and Public Health, Imperial College London, London, UK
   Adaikalavan Ramasamy & Deborah L Jarvis
5. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
   Adaikalavan Ramasamy, Alexessander Couto Alves & Marjo-Riitta Jarvelin
6. Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK
   Adaikalavan Ramasamy
7. Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Health Sciences, University of Copenhagen and Copenhagen University Hospital, Gentofte, Denmark
   Klaus Bønnelykke, Bo Chawes, Eskil Kreiner-Møller & Hans Bisgaard
8. The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
   Liesbeth Duijts, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Ralf J P van der Valk & Vincent W V Jaddoe
9. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
   Liesbeth Duijts, Albert Hofman, André G Uitterlinden, Cornélia M van Duijn, Fernando Rivadeneira, Ralf J P van der Valk & Vincent W V Jaddoe
10. Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Liesbeth Duijts, Johan C de Jongste & Ralf J P van der Valk
11. Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Manuel A Ferreira, David L Duffy, Grant W Montgomery & Nicholas G Martin
12. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    Jacob P Thyssen & Torkil Menné
13. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Eva Albrecht, Martina Müller-Nurasyid & Christian Gieger
14. Department of Dermatology and Allergy, Technische Universität München, Munich, Germany
    Hansjörg Baurecht
15. Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
    Hansjörg Baurecht, Regina Fölster-Holst, Elke Rodríguez & Stephan Weidinger
16. Graduate School of Information Science in Health, Technische Universität München, Munich, Germany
    Hansjörg Baurecht
17. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Bjarke Feenstra, Frank Geller, Heather A Boyd & Mads Melbye
18. The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Patrick M A Sleiman, Cecilia Kim, Frank Mentch, Michael March & Hakon Hakonarson
19. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    Pirro Hysi, Massimo Mangino, Tim D Spector, Veronique Bataille & Daniel Glass
20. School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia
    Nicole M Warrington & Craig E Pennell
21. Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland
    Ivan Curjuric, Medea Imboden & Nicole M Probst-Hensch
22. University of Basel, Basel, Switzerland
    Ivan Curjuric, Medea Imboden & Nicole M Probst-Hensch
23. Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Ronny Myhre & Bo Jacobsson
24. Manchester Academic Health Science Centre, National Institute for Health Research (NIHR) Translational Research Facility in Respiratory Medicine, The University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, UK
    John A Curtin, Angela Simpson & Adnan Custovic
25. Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Maria M Groen-Blokhuis, Jouke-Jan Hottenga & Dorret I Boomsma
26. Department of Epidemiology, Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Marjan Kerkhof
27. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Annika Sääf & Erik Melén
28. Institute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
    Andre Franke & David Ellinghaus
29. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Emmanouil Dermitzakis & Stephen B Montgomery
30. Wellcome Trust Sanger Institute, Cambridge, UK
    Emmanouil Dermitzakis, Stephen B Montgomery & Panos Deloukas
31. Institute of Human Genetics, Technische Universität München, Munich, Germany
    Holger Prokisch
32. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Holger Prokisch & Katharina Heim
33. Department of Obstetrics and Gynaecology, University of Oulu, Oulu, Finland
    Anna-Liisa Hartikainen & Anneli Pouta
34. National Institute for Health and Welfare (THL), Kuopio & Oulu, Finland
    Anneli Pouta, Juha Pekkanen & Marjo-Riitta Jarvelin
35. Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Juha Pekkanen
36. Department of Genomics of Common Disease, Imperial College London, London, UK
    Alexandra I F Blakemore & Jessica L Buxton
37. Institute of Health Sciences, Biocenter Oulu, University of Oulu, Oulu, Finland
    Marika Kaakinen & Marjo-Riitta Jarvelin
38. Washington University School of Medicine, Saint Louis, Missouri, USA
    Pamela A Madden & Andrew C Heath
39. Lung Institute of Western Australia, Perth, Western Australia, Australia
    Philip J Thompson
40. Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Western Australia, Australia
    Philip J Thompson
41. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia
    Melanie C Matheson
42. School of Paediatrics and Child Health, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
    Peter Le Souëf
43. The School of Social & Community Medicine, University of Bristol, Bristol, UK
    Beate St. Pourcain, John Henderson & Susan M Ring
44. Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
    H-Erich Wichmann & Martina Müller-Nurasyid
45. Klinikum Grosshadern, Munich, Germany
    H-Erich Wichmann
46. Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
    Martina Müller-Nurasyid
47. Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany
    Martina Müller-Nurasyid
48. Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    Natalija Novak
49. Unit for Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Norman Klopp & Thomas Illig
50. ZAUM–Center for Allergy and Environment, Helmholtz-Zentrum and Technische Universität, Munich, Germany
    Elke Rodríguez
51. Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, School of Social & Community Medicine, University of Bristol, Bristol, UK
    Wendy McArdle
52. Research Center for Prevention and Health, Glostrup University Hospital, Copenhagen, Denmark
    Allan Linneberg
53. Institute of Public Health, Aarhus University, Aarhus, Denmark
    Ellen A Nohr
54. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    André G Uitterlinden & Fernando Rivadeneira
55. Comprehensive Pneumology Center and Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Matthias Wjst
56. Lung Clinic, Tartu University Hospital, Tartu, Estonia
    Rain Jogi
57. Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Jeffrey C Murray
58. Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
    Patrick G Holt
59. Queensland Children's Medical Research Institute, University of Queensland, World Health Organization (WHO) Collaborating Centre for Research on Children's Environmental Health, Brisbane, Queensland, Australia
    Peter Sly
60. Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Munich, Germany
    Carla M T Tiesler
61. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
    Thomas Illig
62. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Wenche Nystad
63. Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Dirkje Postma
64. Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gerard H Koppelman
65. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Henriette A Smit
66. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Cilla Söderhäll
67. Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
    Erik Melén
68. Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    Bo Jacobsson
69. Ontario Institute for Cancer Research, Toronto, University of Toronto, Toronto, Canada
    Lyle J Palmer
70. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Hakon Hakonarson
71. Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Vincent W V Jaddoe
72. Division of Population Health Sciences and Education, St George's University of London, London, UK
    David P Strachan
73. MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK
    Marjo-Riitta Jarvelin

Authors

1. Lavinia Paternoster
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2. Marie Standl
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3. Chih-Mei Chen
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4. Adaikalavan Ramasamy
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5. Klaus Bønnelykke
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6. Liesbeth Duijts
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7. Manuel A Ferreira
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8. Alexessander Couto Alves
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9. Jacob P Thyssen
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10. Eva Albrecht
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11. Hansjörg Baurecht
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12. Bjarke Feenstra
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13. Patrick M A Sleiman
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14. Pirro Hysi
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15. Nicole M Warrington
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16. Ivan Curjuric
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17. Ronny Myhre
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18. John A Curtin
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19. Maria M Groen-Blokhuis
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20. Marjan Kerkhof
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21. Annika Sääf
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22. Andre Franke
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23. David Ellinghaus
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24. Regina Fölster-Holst
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25. Emmanouil Dermitzakis
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26. Stephen B Montgomery
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27. Holger Prokisch
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28. Katharina Heim
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29. Anna-Liisa Hartikainen
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30. Anneli Pouta
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31. Juha Pekkanen
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32. Alexandra I F Blakemore
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33. Jessica L Buxton
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34. Marika Kaakinen
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35. David L Duffy
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36. Pamela A Madden
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37. Andrew C Heath
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38. Grant W Montgomery
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39. Philip J Thompson
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40. Melanie C Matheson
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41. Peter Le Souëf
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42. Beate St. Pourcain
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43. George Davey Smith
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44. John Henderson
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45. John P Kemp
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46. Nicholas J Timpson
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47. Panos Deloukas
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48. Susan M Ring
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49. H-Erich Wichmann
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50. Martina Müller-Nurasyid
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51. Natalija Novak
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52. Norman Klopp
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53. Elke Rodríguez
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54. Wendy McArdle
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55. Allan Linneberg
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56. Torkil Menné
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57. Ellen A Nohr
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58. Albert Hofman
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59. André G Uitterlinden
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60. Cornélia M van Duijn
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61. Fernando Rivadeneira
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62. Johan C de Jongste
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63. Ralf J P van der Valk
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64. Matthias Wjst
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65. Rain Jogi
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66. Frank Geller
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67. Heather A Boyd
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68. Jeffrey C Murray
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69. Cecilia Kim
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70. Frank Mentch
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71. Michael March
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72. Massimo Mangino
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73. Tim D Spector
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74. Veronique Bataille
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75. Craig E Pennell
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76. Patrick G Holt
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77. Peter Sly
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78. Carla M T Tiesler
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79. Elisabeth Thiering
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80. Thomas Illig
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81. Medea Imboden
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82. Wenche Nystad
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83. Angela Simpson
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84. Jouke-Jan Hottenga
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85. Dirkje Postma
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86. Gerard H Koppelman
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87. Henriette A Smit
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88. Cilla Söderhäll
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89. Bo Chawes
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90. Eskil Kreiner-Møller
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91. Hans Bisgaard
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92. Erik Melén
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93. Dorret I Boomsma
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94. Adnan Custovic
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95. Bo Jacobsson
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96. Nicole M Probst-Hensch
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97. Lyle J Palmer
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98. Daniel Glass
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99. Hakon Hakonarson
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100. Mads Melbye
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101. Deborah L Jarvis
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102. Vincent W V Jaddoe
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103. Christian Gieger
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104. David P Strachan
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105. Nicholas G Martin
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106. Marjo-Riitta Jarvelin
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107. Joachim Heinrich
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108. David M Evans
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Consortia

Australian Asthma Genetics Consortium (AAGC)

The Genetics of Overweight Young Adults (GOYA) Consortium

the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium

• Stephan Weidinger

Contributions

Study-level data analysis: L.P., M.S., A.R., K.B., L.D., M.A.F., A.C.A., J.P.T., E.A., H. Baurecht, B.F., P.H., N.M.W., I.C., R.M., J.A.C., M.M.G.-B., M. Kerkhof, A. Sääf, A.F., D.E., S.B.M., B.S.P., J.P.K., N.J.T., M.M.-N., F.G., M. March, M. Mangino, T.D.S., V.B., C.M.T.T., E.T., M.I., A. Simpson, J.-J.H., H.A.S., B.C., E.K.-M., E.M., A.C., B.J., N.M.P.-H., D.G., D.L.J., H.P., K.H. and D.P.S. Study design: L.P., M.S., C.-M.C., L.D., J.P.T., B.F., P.M.A.S., M. Kerkhof, E.D., A.-L.H., A.P., J.P., M. Kaakinen, G.D.S., J. Henderson, H.-E.W., N.N., A.L., T.M., E.A.N., A.H., A.G.U., C.M.v.D., F.R., J.C.d.J., R.J.P.v.d.V., H.A.B., J.C.M., T.D.S., P.S., W.N., A. Simpson, D.P., G.H.K., H.A.S., H. Bisgaard, D.I.B., A.C., N.M.P.-H., H.H., M. Melbye, D.L.J., V.W.V.J., C.G., M.-R.J., J. Heinrich, D.M.E. and S.W. Manuscript writing: L.P., M.S., A.R., K.B., J. Heinrich, D.M.E. and S.W. Data collection: K.B., L.D., J.P.T., B.F., R.M., M. Kerkhof, R.F.-H., E.D., S.B.M., A.-L.H., A.P., J.P., M. Kaakinen, D.L.D., P.A.M., A.C.H., G.W.M., P.J.T., M.C.M., P.L.S., J. Henderson, S.M.R., W.M., A.L., T.M., E.A.N., J.C.d.J., R.J.P.v.d.V., M.W., R.J., F.G., H.A.B., J.C.M., F.M., T.D.S., V.B., C.E.P., P.G.H., P.S., M.I., W.N., A. Simpson, D.P., G.H.K., H.A.S., B.C., E.K.-M., H. Bisgaard, E.M., D.I.B., A.C., B.J., N.M.P.-H., L.J.P., M. Melbye, D.L.J., V.W.V.J., N.G.M., M.-R.J., J. Heinrich and S.W. Genotyping: R.M., A.F., A.I.F.B., J.L.B., P.D., S.M.R., N.K., E.R., W.M., A.L., A.G.U., F.R., M.W., C.K., C.E.P., T.I., C.S., B.J., L.J.P. and M.-R.J. Revising and reviewing paper: L.P., M.S., C.-M.C., A.R., K.B., L.D., M.A.F., A.C.A., J.P.T., E.A., H. Baurecht, B.F., P.M.A.S., P.H., N.M.W., I.C., R.M., J.A.C., M.M.G.-B., M. Kerkhof, A. Sääf, A.F., D.E., R.F. -H., E.D., S.B.M., A.-L.H., A.P., J.P., A.I.F.B., J.L.B., M. Kaakinen, D.L.D., P.A.M., A.C.H., G.W.M., P.J.T., M.C.M., P.L.S., B.S.P., G.D.S., J. Henderson, J.P.K., N.J.T., P.D., S.M.R., H.-E.W., M.M.-N., N.N., N.K., E.R., W.M., A.L., T.M., E.A.N., A.H., A.G.U., C.M.v.D., F.R., J.C.d.J., R.J.P.v.d.V., M.W., R.J., F.G., H.A.B., J.C.M., C.K., F.M., M. March, M. Mangino, T.D.S., V.B., C.E.P., P.G.H., P.S., C.M.T.T., E.T., T.I., M.I., W.N., A. Simpson, J.-J.H., D.P., G.H.K., H.A.S., C.S., B.C., E.K.-M., H. Bisgaard, E.M., D.I.B., A.C., B.J., N.M.P.-H., L.J.P., D.G., H.H., M. Melbye, D.L.J., V.W.V.J., C.G., D.P.S., N.G.M., M.-R.J., J. Heinrich, D.M.E., H.P., K.H. and S.W.

AAGC provided results for the replication analysis, and GOYA provided results for the discovery analysis.

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Correspondence toLavinia Paternoster.

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Competing interests

D.P. received funding for research from AstraZeneca, GlaxoSmithKline (GSK) and Nycomed. Travel to the European Respiratory Society (ERS) or American Thoracic Society (ATS) conferences was partially funded by AstraZeneca, GSK, Chiesi and Nycomed. She has been a consultant for AstraZeneca, Boehringer Ingelheim, Chiesi, GSK, Nycomed and Teva Pharmaceutical Industries.

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Paternoster, L., Standl, M., Chen, CM. et al. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.Nat Genet 44, 187–192 (2012). https://doi.org/10.1038/ng.1017

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• Received: 08 July 2011
• Accepted: 01 November 2011
• Published: 25 December 2011
• Issue Date: February 2012
• DOI: https://doi.org/10.1038/ng.1017