Meta-analysis identifies six new susceptibility loci for atrial fibrillation (original) (raw)

References

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Acknowledgements

Acknowledgments are contained in the Supplementary Note.

Author information

Author notes

1. Patrick T Ellinor, Kathryn L Lunetta, Christine M Albert, Nicole L Glazer, Marylyn D Ritchie, Albert V Smith, Dan E Arking, Martina Müller-Nurasyid, Bouwe P Krijthe, Steven A Lubitz, Joshua C Bis, Mina K Chung, Marcus Dörr and Kouichi Ozaki: These authors contributed equally to this work.
2. Toshihiro Tanaka, Bruno H Ch Stricker, Stephan B Felix, Alvaro Alonso, Dawood Darbar, John Barnard, Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Vilmundur Gudnason and Stefan Kääb: These authors jointly directed this work.

Authors and Affiliations

1. Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
   Patrick T Ellinor, Steven A Lubitz, Moritz F Sinner, Michiel Rienstra, David J Milan & Saagar Mahida
2. Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA
   Patrick T Ellinor & David J Milan
3. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
   Patrick T Ellinor & Jonathan Rosand
4. Harvard Medical School, Boston, Massachusetts, USA
   Patrick T Ellinor, Christine M Albert, Usha B Tedrow, Paul M Ridker, Karen L Furie, Jonathan Rosand & Daniel I Chasman
5. Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA
   Kathryn L Lunetta & Siyan Xu
6. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
   Kathryn L Lunetta, Moritz F Sinner, Jared W Magnani, Daniel Levy & Emelia J Benjamin
7. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
   Christine M Albert, Steven A Lubitz, Usha B Tedrow, Lynda M Rose, Paul M Ridker & Daniel I Chasman
8. Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
   Christine M Albert, Usha B Tedrow & Paul M Ridker
9. Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
   Nicole L Glazer, Joshua C Bis, Nicholas L Smith, Guo Li, Nona Sotoodehnia, Bruce M Psaty & Susan R Heckbert
10. Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USA
    Marylyn D Ritchie
11. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    Marylyn D Ritchie
12. Icelandic Heart Association Research Institute, Kopavogur, Iceland
    Albert V Smith & Vilmundur Gudnason
13. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Albert V Smith & Vilmundur Gudnason
14. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Dan E Arking & Aravinda Chakravarti
15. Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    Martina Müller-Nurasyid, Moritz F Sinner, Reza Wakili, Sebastian Clauss, Gerhard Steinbeck & Stefan Kääb
16. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
    Martina Müller-Nurasyid
17. Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
    Martina Müller-Nurasyid & Bruno H Ch Stricker
18. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Bouwe P Krijthe, Albert Hofman, Jacqueline C M Witteman, Andre G Uitterlinden & Fernando Rivadeneira
19. Netherlands Consortium for Healthy Aging (NCHA), The Netherlands
    Bouwe P Krijthe, Albert Hofman, Jacqueline C M Witteman, Andre G Uitterlinden, Fernando Rivadeneira & Bruno H Ch Stricker
20. Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Mina K Chung, Jonathan D Smith & David R Van Wagoner
21. Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Mina K Chung & David R Van Wagoner
22. Department of Internal Medicine B, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Marcus Dörr & Stephan B Felix
23. Laboratory for Cardiovascular Diseases, RIKEN Center for Genomic Medicine, Kanagawa, Japan
    Kouichi Ozaki & Toshihiro Tanaka
24. Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Jason D Roberts, Matthew Borkovich & Michael H Gollob
25. Department of Cardiology, Lund University, Lund, Sweden
    J Gustav Smith
26. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
    J Gustav Smith, Benjamin F Voight & Sekar Kathiresan
27. Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
    Arne Pfeufer & Thomas Meitinger
28. Institute of Human Genetics, Technische Universität (TU) München, Klinikum Rechts der Isar, Munich, Germany
    Arne Pfeufer & Thomas Meitinger
29. Department of Biostatistical Sciences, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Kurt Lohman
30. Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
    Jingzhong Ding
31. Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA
    Nicholas L Smith
32. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
    Nicholas L Smith, Bruce M Psaty & Susan R Heckbert
33. Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Nicholas L Smith, Bruce M Psaty & Susan R Heckbert
34. Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Jonathan D Smith
35. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Michiel Rienstra
36. Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Kenneth M Rice & Barbara McKnight
37. Department of Medicine, Cardiology Section, Boston University School of Medicine, Boston, Massachusetts, USA
    Jared W Magnani, Honghuang Lin & Emelia J Benjamin
38. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Jerome I Rotter
39. Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA
    Lenore J Launer & Tamara B Harris
40. Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Robert W Davies
41. Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Uwe Völker
42. Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Henry Völzke
43. Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Eric Boerwinkle
44. Cardiovascular Division, Department of Medicine, Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Lin Y Chen
45. Epidemiological Cardiology Research Center (EPICARE), Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Elsayed Z Soliman
46. Laboratory for Genotyping Development, RIKEN Center for Genomic Medicine, Kanagawa, Japan
    Michiaki Kubo
47. Department of Medicine, University Hospital, Basel, Switzerland
    David Conen
48. Laboratory for Medical Informatics, RIKEN Center for Genomic Medicine, Kanagawa, Japan
    Tatsuhiko Tsunoda
49. Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Tetsushi Furukawa
50. Division of Cardiology, University of Washington, Seattle, Washington, USA
    Nona Sotoodehnia
51. Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA
    Siyan Xu & Emelia J Benjamin
52. Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Kanagawa, Japan
    Naoyuki Kamatani
53. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Yusuke Nakamura
54. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Babar Parvez, Raafia Muhammad, Dan M Roden & Dawood Darbar
55. Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Karen L Furie & Jonathan Rosand
56. Department of Health Services, University of Washington, Seattle, Washington, USA
    Bruce M Psaty
57. Institute for Biological and Medical Imaging, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
    Siegfried Perz
58. Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
    H-Erich Wichmann
59. Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany
    H-Erich Wichmann
60. Klinikum Grosshadern, Munich, Germany
    H-Erich Wichmann
61. Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    W H Linda Kao
62. The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    W H Linda Kao
63. Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Sekar Kathiresan
64. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Dan M Roden
65. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Andre G Uitterlinden, Fernando Rivadeneira & Bruno H Ch Stricker
66. Department of Clinical Sciences, Lund University, Malmo, Sweden
    Marketa Sjögren & Olle Melander
67. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Anne B Newman
68. Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
    Yongmei Liu
69. Inspectorate for Health Care, The Hague, The Netherlands
    Bruno H Ch Stricker
70. Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
    Bruno H Ch Stricker
71. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Alvaro Alonso
72. Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    John Barnard
73. Department of Medicine, Preventive Medicine Section, Boston University School of Medicine, Boston, Massachusetts, USA
    Emelia J Benjamin
74. Munich Heart Alliance, Munich, Germany
    Stefan Kääb

Authors

1. Patrick T Ellinor
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2. Kathryn L Lunetta
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3. Christine M Albert
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4. Nicole L Glazer
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5. Marylyn D Ritchie
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6. Albert V Smith
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7. Dan E Arking
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8. Martina Müller-Nurasyid
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9. Bouwe P Krijthe
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10. Steven A Lubitz
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11. Joshua C Bis
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12. Mina K Chung
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13. Marcus Dörr
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14. Kouichi Ozaki
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15. Jason D Roberts
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16. J Gustav Smith
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17. Arne Pfeufer
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18. Moritz F Sinner
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19. Kurt Lohman
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20. Jingzhong Ding
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21. Nicholas L Smith
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22. Jonathan D Smith
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23. Michiel Rienstra
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24. Kenneth M Rice
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25. David R Van Wagoner
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26. Jared W Magnani
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27. Reza Wakili
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28. Sebastian Clauss
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29. Jerome I Rotter
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30. Gerhard Steinbeck
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31. Lenore J Launer
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32. Robert W Davies
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33. Matthew Borkovich
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34. Tamara B Harris
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35. Honghuang Lin
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36. Uwe Völker
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37. Henry Völzke
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38. David J Milan
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39. Albert Hofman
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40. Eric Boerwinkle
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41. Lin Y Chen
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42. Elsayed Z Soliman
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43. Benjamin F Voight
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44. Guo Li
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45. Aravinda Chakravarti
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46. Michiaki Kubo
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47. Usha B Tedrow
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48. Lynda M Rose
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49. Paul M Ridker
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50. David Conen
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51. Tatsuhiko Tsunoda
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52. Tetsushi Furukawa
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53. Nona Sotoodehnia
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54. Siyan Xu
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55. Naoyuki Kamatani
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56. Daniel Levy
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57. Yusuke Nakamura
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58. Babar Parvez
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59. Saagar Mahida
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60. Karen L Furie
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61. Jonathan Rosand
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62. Raafia Muhammad
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63. Bruce M Psaty
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64. Thomas Meitinger
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65. Siegfried Perz
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66. H-Erich Wichmann
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67. Jacqueline C M Witteman
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68. W H Linda Kao
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69. Sekar Kathiresan
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70. Dan M Roden
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71. Andre G Uitterlinden
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72. Fernando Rivadeneira
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73. Barbara McKnight
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74. Marketa Sjögren
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75. Anne B Newman
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76. Yongmei Liu
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77. Michael H Gollob
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78. Olle Melander
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79. Toshihiro Tanaka
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80. Bruno H Ch Stricker
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81. Stephan B Felix
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82. Alvaro Alonso
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83. Dawood Darbar
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84. John Barnard
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85. Daniel I Chasman
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86. Susan R Heckbert
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87. Emelia J Benjamin
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88. Vilmundur Gudnason
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89. Stefan Kääb
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Study concept and design was determined by P.T.E., K.L.L., C.M.A., B.P.K., M.K.C., J.D., H.V., A.H., Y.N., D.M.R., A.G.U., A.B.N., Y.L., T. Tanaka, B.H.C.S., S.B.F., D.D., S.R.H., E.J.B., V.G. and S. Kääb. Acquisition of data was performed by P.T.E., C.M.A., N.L.G., J.C.B., M.K.C., M.D., J.D.R., A.P., M.F.S., J.D., N.L.S., J.D.S., R.W., J.I.R., L.J.L., T.B.H., U.V., A.H., E.Z.S., M.K., U.B.T., D.C., T.F., R.M., B.M.P., T.M., S.P., H.-E.W., J.C.M.W., A.G.U., F.R., M.S., A.B.N., Y.L., M.H.G., B.H.C.S., A.A., S.R.H., E.J.B., V.G., B.P., H.L., B.F.V., M.B., W.H.L.K. and S. Kääb. Analysis and interpretation of data were performed by P.T.E., K.L.L., N.L.G., M.D.R., A.V.S., D.E.A., M.M.-N., B.P.K., S.A.L., J.C.B., M.D., K.O., J.D.R., J.G.S., M.F.S., K.L., J.D., N.L.S., K.M.R., J.I.R., R.W.D., U.V., G.L., T. Tsunoda, N.S., N.K., B.M.P., S. Kathiresan, D.M.R., B.M., Y.L., M.H.G., D.D., S.R.H., H.L., S.X. and E.J.B. Drafting of the manuscript was carried out by P.T.E., K.L.L., B.P.K., S.A.L. and S. Kääb. Critical revision of the manuscript for important intellectual content was carried out by C.M.A., N.L.G., A.V.S., D.E.A., B.P.K., J.C.B., M.K.C., M.D., J.G.S., A.P., M.F.S., J.D., N.L.S., J.D.S., M.R., K.M.R., D.R.V.W., J.W.M., R.W., J.I.R., L.J.L., T.B.H., U.V., H.V., D.J.M., A.H., L.Y.C., E.Z.S., G.L., U.B.T., P.M.R., D.C., N.S., S.M., K.L.F., B.M.P., T.M., S.P., J.C.M.W., D.M.R., A.G.U., F.R., B.M., M.S., A.B.N., Y.L., M.H.G., O.M., B.H.C.S., S.B.F., A.A., D.D., D.I.C., S.R.H., E.J.B., G.S., S.C., A.C., D.L., J.R. and V.G. Statistical analysis was performed by K.L.L., N.L.G., M.D.R., A.V.S., D.E.A., M.M.-N., B.P.K., J.C.B., J.G.S., M.F.S., K.L., J.D., K.M.R., R.W.D., U.V., G.L., L.M.R., Y.L. and D.I.C. Funding was obtained by P.T.E., C.M.A., M.K.C., J.G.S., N.L.S., J.D.S., J.I.R., L.J.L., T.B.H., H.V., A.H., E.B., U.B.T., P.M.R., B.M.P., T.M., H.-E.W., J.C.M.W., D.M.R., A.G.U., Y.L., O.M., B.H.C.S., S.B.F., A.A., D.D., S.R.H., E.J.B., V.G. and S. Kääb. Study supervision was performed by P.T.E., K.L.L., C.M.A., M.K.C., N.L.S., J.I.R., A.H., P.M.R., B.M.P., J.C.M.W., A.G.U., Y.L., B.H.C.S., S.B.F., S.R.H., E.J.B., V.G. and S. Kääb., P.T.E., K.L.L., C.M.A., N.L.G., M.D.R., A.V.S., D.E.A., M.M.-N., B.P.K., J.C.B., M.K.C., M.D., K.O., T. Tanaka, B.H.C.S., S.B.F., A.A., D.D., J.B., D.I.C., S.R.H., V.G., E.J.B. and S. Kääb had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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Correspondence toPatrick T Ellinor or Stefan Kääb.

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Ellinor, P., Lunetta, K., Albert, C. et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation.Nat Genet 44, 670–675 (2012). https://doi.org/10.1038/ng.2261

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• Received: 30 August 2011
• Accepted: 05 April 2012
• Published: 29 April 2012
• Issue Date: June 2012
• DOI: https://doi.org/10.1038/ng.2261