A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12 (original) (raw)

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Acknowledgements

This study was funded by the Fund of the Key Basic Research and Development Program Foundation of China (973 Program) from the Ministry of Science and Technology of China (2009CB521808 and 2013CB911304), grants from the National Natural Science Foundation of China (81230038, 81025011, 81090414, 30973472, 81071663, 81130022, 81121001, 81230052, 81272302, 31000553, 81172464 and 81101964), Key Projects in the National Science and Technology Pillar Program during the Eleventh Five-Year Plan Period (2008BAI57B01), the High-Tech Research and Development Program of China (863 Program) (2012AA020801 and 2012AA02A515) and the Fund of the Key Laboratory of Cancer Invasion and Metastasis from Hubei Province and Tongji Hospital (HB001 and xkdy28). This work was also partially supported by the Hubei Research and Development Program (2008BCC005, 2009BCC001 and 2010BCB006), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1025), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), the Program for New Century Excellent Talents in University (NCET-09-0550) and the Shanghai Rising-Star Program (12QA1401900). We thank all participants recruited for this study. We would like to thank S. Liu, G. Wu, Z. Wang, S. Xie, S. Chen, Q. Wu, Y. Lu, B. Cao, Y. Li, Q. Chen, D. Zhu, M. Gong, S. Sun, Y. Wang, Y. Qin, R. Yang, J. Feng, T. Wang, L. Shi, J. Jiang, F. Rong, W. Zhou, M. Qian, X. Wu, X. Xia, Y. Yan, Y. Fan, M. Cao, C. Sun, Q. Ling, J. Yang, B. Zhou, Z. Zeng, L. Tang, L. Yu, Y. Han, J. Zhou, Y. Fang, P. Chen and Y. Meng for their useful help.

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Author notes

1. Yongyong Shi, Li Li, Zhibin Hu, Shuang Li, Shixuan Wang, Jihong Liu and Chen Wu: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
   Yongyong Shi, Shuang Li, Shixuan Wang, Ting Hu, Yao Jia, Shaoshuai Wang, Ru Yang, Xiong Li, Kecheng Huang, Qinghua Zhang, Hang Zhou, Fangxu Tang, Zhilan Chen, Jian Shen, Dongrui Deng, Ling Xi, Hui Wang, Dan Liu, Ee Gong & Ding Ma
2. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
   Yongyong Shi, Lin He, Zhiqiang Li, Jiawei Shen, Jianhua Chen & Wenjin Li
3. Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China
   Yongyong Shi, Lin He, Zhiqiang Li & Jiawei Shen
4. Changning Mental Health Center, Shanghai, China
   Yongyong Shi, Lin He, Zhiqiang Li & Jiawei Shen
5. Department of Gynecologic Oncology, Guangxi Province Tumor Hospital, Nanning, China
   Li Li, Zhijun Yang & Zhuang Li
6. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
   Zhibin Hu, Jie Jiang, Shandong Pan, Yang Wen, Minjie Chu & Hongbing Shen
7. Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing, China
   Zhibin Hu, Jie Jiang, Shandong Pan, Yang Wen, Minjie Chu & Hongbing Shen
8. Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
   Jihong Liu & Zheng Li
9. State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
   Chen Wu & Dongxin Lin
10. Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Jianfeng Zhou, Hu Ding & Daowen Wang
11. Department of Gynecologic Oncology, Hunan Province Tumor Hospital, Changsha, China
    Yile Chen & Li Wu
12. Women's Hospital, School of Medicine Zhejiang University, Hangzhou, China
    Xiaodong Cheng, Weiguo Lv, Yuanming Shen & Xing Xie
13. Department of Obstetrics and Gynecology, Xiangyang Central Hospital, First Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China
    Hui Xing
14. Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China
    Shulan Zhang & Xiaomei Luan
15. Tianjin Central Hospital for Gynecology and Obstetrics, Tianjin, China
    Pengpeng Qu & Limei Zhou
16. Wuhan Medical Center for Women and Children, Wuhan, China
    Xiaojie Song
17. Department of Gynecologic Oncology, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Zhongqiu Lin
18. Department of Obstetrics and Gynecology, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China
    Xiaobing Han
19. Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, China
    Guangshi Tao
20. Blood Center of Zhejiang Province, Key Laboratory of Blood Safety of Ministry of Health, Hangzhou, China
    Lixing Yan & Zhedong Han
21. Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Xiaoping Miao
22. Department of Obstetrics and Gynecology, Huangshi Central Hospital, Huangshi, China
    Chuping Wang
23. Department of Obstetrics and Gynecology, Xiaogan Central Hospital, Xiaogan, China
    Qian Song
24. Department of Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, China
    Sufang Wu & Youji Feng
25. Department of Gynecology and Obstetrics, People's Hospital of Shenzhen, Shenzhen, China
    Hongbin Xu
26. Nantong Tumor Hospital, Nantong, China
    Fulin Qiang, Li Liu, Xiaojun Chen & Jibin Liu
27. Department of Obstetrics and Gynecology, Guangxi Maternal and Child Health Hospital, Nanning, China
    Gang Ma
28. Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, China
    Jiangping Wu & Yan Shen
29. Maternal and Child Center, No. 181 Hospital of the People's Liberation Army, Guilin, China
    Jiang Yu
30. Department of Obstetrics and Gynecology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
    Xiaoxia Hu
31. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Guangxi University of Medical Science, Nanning, China
    Yujuan Fan
32. Department of Obstetrics and Gynecology, Liuzhou Worker Hospital, Liuzhou, China
    Hongying He
33. Department of Obstetrics and Gynecology, the People's Hospital of Liuzhou, Liuzhou, China
    Yanming Jiang
34. Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, China
    Zhiying Lei
35. Department of Obstetrics and Gynecology, The Red Cross Hospital of Yulin City, Yulin, China
    Cui Liu
36. Shanghai Institute of Mental Health, Shanghai, China
    Jianhua Chen
37. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Yuan Zhang & Zehua Wang
38. Department of Obstetrics and Gynecology, the First People's Hospital of Jingzhou City, Jingzhou, China
    Cunjian Yi
39. Department of Gynecologic Oncology, Taihe Hospital of Shiyan, Shiyan, China
    Shuangyun Chen
40. Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Wen Di
41. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Keng Shen

Authors

1. Yongyong Shi
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2. Li Li
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3. Zhibin Hu
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4. Shuang Li
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5. Shixuan Wang
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6. Jihong Liu
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7. Chen Wu
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8. Lin He
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9. Jianfeng Zhou
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10. Zhiqiang Li
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11. Ting Hu
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12. Yile Chen
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13. Yao Jia
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14. Shaoshuai Wang
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15. Li Wu
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16. Xiaodong Cheng
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17. Zhijun Yang
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18. Ru Yang
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19. Xiong Li
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20. Kecheng Huang
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21. Qinghua Zhang
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22. Hang Zhou
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23. Fangxu Tang
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24. Zhilan Chen
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25. Jian Shen
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26. Jie Jiang
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27. Hu Ding
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28. Hui Xing
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29. Shulan Zhang
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30. Pengpeng Qu
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31. Xiaojie Song
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32. Zhongqiu Lin
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33. Dongrui Deng
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34. Ling Xi
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35. Weiguo Lv
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36. Xiaobing Han
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37. Guangshi Tao
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38. Lixing Yan
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39. Zhedong Han
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40. Zhuang Li
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41. Xiaoping Miao
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42. Shandong Pan
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43. Yuanming Shen
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44. Hui Wang
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45. Dan Liu
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46. Ee Gong
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47. Zheng Li
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48. Limei Zhou
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49. Xiaomei Luan
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50. Chuping Wang
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51. Qian Song
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52. Sufang Wu
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53. Hongbin Xu
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54. Jiawei Shen
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55. Fulin Qiang
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56. Gang Ma
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57. Li Liu
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58. Xiaojun Chen
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59. Jibin Liu
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60. Jiangping Wu
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61. Yan Shen
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62. Yang Wen
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63. Minjie Chu
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64. Jiang Yu
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65. Xiaoxia Hu
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66. Yujuan Fan
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67. Hongying He
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68. Yanming Jiang
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69. Zhiying Lei
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70. Cui Liu
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71. Jianhua Chen
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72. Yuan Zhang
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73. Cunjian Yi
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74. Shuangyun Chen
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75. Wenjin Li
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76. Daowen Wang
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77. Zehua Wang
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78. Wen Di
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79. Keng Shen
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80. Dongxin Lin
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81. Hongbing Shen
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82. Youji Feng
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83. Xing Xie
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84. Ding Ma
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Contributions

D.M. took full responsibility for the study, especially in conceiving, designing and supervising the research together with Y. Shi and X.X. S.L., L. Li, Z. Hu, Shixuan Wang and J.Z. participated in the study design. D.M., S.L., X.X., L. Li, Z. Hu and Shixuan Wang supervised the diagnosis of patients and subject recruitment. Y. Shi and S.L. supervised the experiments and data analyses. Y. Shi, Zhiqiang Li, X. Li, S.L., T.H. and Z. Han performed statistical analyses, and the results were interpreted by D.M., S.L., Y. Shi and X.X. D.M., X.X., L.H., Y. Shi, L. Li, H.S., Z. Hu, J.Z., Shixuan Wang, S.L., Jihong Liu, D. Lin, C. Wu, Y.C., H. Xing, S.Z., P.Q., Y. Fan, W.D., K.S., X.S., D.W., H.D., Z. Lin, D.D., L.X., X. Cheng, W. Lv, X. Han, G.T., X.M., H.W., F.Q., L. Liu, X. Chen, Jibin Liu, J.W., Yan Shen, L.Y., Z.Y., J.Y., G.M., X. Hu, Y. Feng, H.H., Y. Jiang, Z. Lei, C.L., Y.Z., Z.W., C.Y., S.C., Yuanming Shen, S. Wu, H. Xu, C. Wang and Q.S. contributed reagents, materials and analysis tools and provided samples from different hospitals. S.L., Y. Shi, T.H., Y. Jia, Shaoshuai Wang, R.Y., Z. Hu, L.W., X. Li, K.H., Z.C., Jian Shen, Q.Z., H.Z., F.T., E.G., D. Liu, J.J., Wenjin Li, Jiawei Shen, S.P., Zhuang Li, L.Z., X. Luan, Y.W., M.C., J.C., Jihong Liu and Zheng Li performed the experiments. D.W., X.M. and H.D. provided technical support. The manuscript was drafted by S.L. and Zhiqiang Li under the supervision of D.M., Y. Shi and X.X. All authors critically reviewed the article and approved the final manuscript.

Corresponding authors

Correspondence toYongyong Shi, Xing Xie or Ding Ma.

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The authors declare no competing financial interests.

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Shi, Y., Li, L., Hu, Z. et al. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.Nat Genet 45, 918–922 (2013). https://doi.org/10.1038/ng.2687

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• Received: 09 April 2013
• Accepted: 07 June 2013
• Published: 30 June 2013
• Issue Date: August 2013
• DOI: https://doi.org/10.1038/ng.2687