HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin (original) (raw)

• Mann, R. & Andrews, E. (eds.). Pharmacovigilance (John Wiley and Sons, Chichester, 2006).
  Book Google Scholar
• Sgro, C. et al. Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology 36, 451–455 (2002).
  Article Google Scholar
• Ostapowicz, G. et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Intern. Med. 137, 947–954 (2002).
  Article Google Scholar
• Olsson, R. et al. Liver damage fron flucloxacillin, cloxacillin and dicloxacillin. J. Hepatol. 15, 154–161 (1992).
  Article CAS Google Scholar
• Fairley, C.K., McNeil, J. & Desmond, P. Risk factors for development of flucloxacillin associated jaundice. Br. Med. J. 306, 233–235 (1993).
  Article CAS Google Scholar
• Russmann, S., Kaye, J.A., Jick, S.S. & Jick, H. Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research Database. Br. J. Clin. Pharmacol. 60, 76–82 (2005).
  Article CAS Google Scholar
• Hautekeete, M.L. et al. HLA association of amoxicillin-clavulanate-induced hepatitis. Gastroenterology 117, 1181–1186 (1999).
  Article CAS Google Scholar
• O'Donohue, J. et al. Co-amoxiclav jaundice: clinical and histological features and HLA class II association. Gut 47, 717–720 (2000).
  Article CAS Google Scholar
• Kindmark, A. et al. Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis. Pharmacogenomics J. 8, 186–195 (2008).
  Article CAS Google Scholar
• Lakehal, F. et al. Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes. Chem. Res. Toxicol. 14, 694–701 (2001).
  Article CAS Google Scholar
• Maria, V.A. & Victorino, R.M. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury. Gut 41, 534–540 (1997).
  Article CAS Google Scholar
• Danan, G. & Benichou, C. Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J. Clin. Epidemiol. 46, 1323–1330 (1993).
  Article CAS Google Scholar
• Novembre, J. et al. Genes mirror geography within Europe. Nature 456, 98–101 (2008).
  Article CAS Google Scholar
• de Bakker, P.I. et al. Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum. Mol. Genet. 17, R122–R128 (2008).
  Article CAS Google Scholar
• Colombo, S. et al. The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J. Infect. Dis. 198, 864–867 (2008).
  Article CAS Google Scholar
• Pachkoria, K. et al. Analysis of IL-10, IL-4 and TNF-α polymorphisms in drug-induced liver injury (DILI) and its outcome. J. Hepatol. 49, 107–114 (2008).
  Article CAS Google Scholar
• Aithal, G.P. et al. Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology 39, 1430–1440 (2004).
  Article CAS Google Scholar
• Donaldson, P.T. Genetics of liver disease: immunogenetics and disease pathogenesis. Gut 53, 599–608 (2004).
  Article CAS Google Scholar
• Ahmad, T. et al. Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC. Hum. Mol. Genet. 12, 647–656 (2003).
  Article CAS Google Scholar
• Browner, W.S. & Newman, T.B. Sample size and power based on the population attributable fraction. Am. J. Public Health 79, 1289–1294 (1989).
  Article CAS Google Scholar
• Bast, B.J. et al. The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the β-galactoside α 2,6-sialyltransferase. J. Cell Biol. 116, 423–435 (1992).
  Article CAS Google Scholar
• Hetherington, S. et al. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir. Clin. Ther. 23, 1603–1614 (2001).
  Article CAS Google Scholar
• Chessman, D. et al. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity 28, 822–832 (2008).
  Article CAS Google Scholar
• Fellay, J. et al. A whole-genome association study of major determinants for host control of HIV-1. Science 317, 944–947 (2007).
  Article CAS Google Scholar
• Kaplan, H.A., Woloski, B.M., Hellman, M. & Jamieson, J.C. Studies on the effect of inflammation on rat liver and serum sialyltransferase. J. Biol. Chem. 258, 11505–11509 (1983).
  CAS PubMed Google Scholar
• Nasirikenari, M., Segal, B.H., Ostberg, J.R., Urbasic, A. & Lau, J.T. Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I. Blood 108, 3397–3405 (2006).
  Article CAS Google Scholar
• Sutherland, R., Croydon, E.A. & Rolinson, G.N. Flucloxacillin, a new isoxazolyl penicillin, compared with oxacillin, cloxacillin, and dicloxacillin. BMJ 4, 455–460 (1970).
  Article CAS Google Scholar
• Saxena, R. et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331–1336 (2007).
  Article CAS Google Scholar
• Willer, C.J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34 (2009).
  Article CAS Google Scholar
• Nelson, M.R. et al. Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions. Pharmacogenomics J. 9, 23–33 (2008).
  Article Google Scholar
• Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).
  Article CAS Google Scholar
• Grove, J., Daly, A.K., Bassendine, M.F. & Day, C.P. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology 26, 143–146 (1997).
  Article CAS Google Scholar
• Daly, A.K., King, B.P. & Leathart, J.B. Genotyping for cytochrome P450 polymorphisms. Methods Mol. Biol. 320, 193–207 (2006).
  CAS PubMed Google Scholar
• Nelson, M.R. et al. The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am. J. Hum. Genet. 83, 347–358 (2008).
  Article CAS Google Scholar
• Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904–909 (2006).
  Article CAS Google Scholar
• Svejgaard, A. & Ryder, L.P. HLA and disease associations: detecting the strongest association. Tissue Antigens 43, 18–27 (1994).
  Article CAS Google Scholar
• Dudbridge, F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum. Hered. 66, 87–98 (2008).
  Article Google Scholar