Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels (original) (raw)

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Acknowledgements

We thank the participants and research teams involved in LOLIPOP and NFBC1966, including P. Rantakallio, O. Tornwall and M. Jussila. The LOLIPOP study was supported by the British Heart Foundation (SP/04/002) and the Wellcome Trust. NFBC1966 was supported by the Academy of Finland (project grants 104781, 120315 and Center of Excellence in Complex Disease Genetics), University Hospital Oulu, Biocenter, University of Oulu, Finland, National Heart, Lung, and Blood Institute (US) grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Medical Research Council (UK) (studentship grant G0500539, centre grant G0600705), the Wellcome Trust (UK) (project grant GR069224) and the Research Council UK fellowship. We thank the National Public Health Institute, Biomedicum Helsinki, Finland, supported financially by the Academy of Finland and Biocentrum Helsinki, for DNA extraction, sample quality controls, biobank upkeep and aliquotting.

Author information

Author notes

  1. John C Chambers, Weihua Zhang, James Scott, Paul Elliott and Jaspal S Kooner: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Epidemiology and Public Health, Imperial College London, London, UK
    John C Chambers, Weihua Zhang, Delilah Zabaneh, Clive Hoggart, Marjo-Riitta Jarvelin & Paul Elliott
  2. Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Yun Li & Gonçalo Abecasis
  3. National Heart and Lung Institute, London, UK
    Joban Sehmi, James Scott & Jaspal S Kooner
  4. Structural Bioinformatics Group, Imperial College London, London, UK
    Mark N Wass & Michael J E Sternberg
  5. Department of Structural & Molecular Biology, University College London, London, UK
    Henry Bayele & Surjit K Srai
  6. Oxford Centre for Diabetes, Endocrinology and Metabolism and Oxford NIHR Biomedical Research Centre, Oxford, UK
    Mark I McCarthy
  7. Wellcome Trust Sanger Institute, Cambridge, UK
    Leena Peltonen
  8. Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA
    Nelson B Freimer
  9. Division of Medicine, University College of London, London, UK
    Patrick H Maxwell
  10. Department of Clinical Chemistry, University Hospital Oulu, Oulu, Finland
    Aimo Ruokonen
  11. Institute of Health Sciences, Oulu, Finland
    Marjo-Riitta Jarvelin
  12. Biocenter Oulu, University of Oulu, Oulu, Finland
    Marjo-Riitta Jarvelin

Authors

  1. John C Chambers
  2. Weihua Zhang
  3. Yun Li
  4. Joban Sehmi
  5. Mark N Wass
  6. Delilah Zabaneh
  7. Clive Hoggart
  8. Henry Bayele
  9. Mark I McCarthy
  10. Leena Peltonen
  11. Nelson B Freimer
  12. Surjit K Srai
  13. Patrick H Maxwell
  14. Michael J E Sternberg
  15. Aimo Ruokonen
  16. Gonçalo Abecasis
  17. Marjo-Riitta Jarvelin
  18. James Scott
  19. Paul Elliott
  20. Jaspal S Kooner

Contributions

J.C.C., P.E., G.A., J. Scott and J.K. designed the study. J.C.C., J. Sehmi, M.-R.J., A.R. and J.K. supervised patient recruitment. J.C.C., P.E., J. Scott, G.A., M.I.M., H.B., L.P., N.B.F., M.J.E.S., P.H.M., S.K.S., M.-R.J., A.R. and J.K. supervised the experiments. J.C.C., W.Z., D.Z., Y.L., C.H. and M.N.W. performed data analysis. J.C.C., P.E., J. Scott and J.S.K. wrote the manuscript. All authors commented on and approved the manuscript.

Corresponding authors

Correspondence toJohn C Chambers or Jaspal S Kooner.

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Chambers, J., Zhang, W., Li, Y. et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.Nat Genet 41, 1170–1172 (2009). https://doi.org/10.1038/ng.462

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