Meta-analysis and imputation refines the association of 15q25 with smoking quantity (original) (raw)
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Acknowledgements
GlaxoSmithKline (GSK), a pharmaceuticals company that is interested in developing new cessation therapies for smoking, funded a postdoctoral fellowship for J.Z.L. at Oxford University. GSK also funded the collection, characterization, and, in some cases, the genotyping and genotype data preparation for several of the cohorts used in this study. A. Roses and P. Matthews played crucial roles in establishing and funding the Medical Genetics activities at GSK. Acknowledgments that are specific to individual cohorts are given in the Supplementary Note.
Author information
Author notes
- Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
Authors and Affiliations
- Department of Statistics, University of Oxford, Oxford, UK
Jason Z Liu & Jonathan Marchini - Genetics Division, GlaxoSmithKline, Verona, Italy
Federica Tozzi, Pierandrea Muglia & Clyde Francks - Genetics Division, GlaxoSmithKline, Upper Merion, Pennsylvania, USA
Dawn M Waterworth, Sreekumar G Pillai, Xin Yuan & Vincent Mooser - Division of Neurosciences and Mental Health, Imperial College London, UK
Lefkos Middleton - Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Wade Berrettini - Genetics Division, GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Christopher W Knouff - University Hospital Center, University of Lausanne, Lausanne, Switzerland
Gérard Waeber, Peter Vollenweider & Martin Preisig - Department of Internal Medicine, University of Lausanne, Lausanne, Switzerland
Gérard Waeber & Peter Vollenweider - Department of Psychiatry, University of Lausanne, Lausanne, Switzerland
Martin Preisig - Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
Nicholas J Wareham, Jing Hua Zhao & Ruth J F Loos - Wellcome Trust Sanger Institute, Hinxton, UK
Inês Barroso & Carl A Anderson - Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Kay-Tee Khaw - Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Scott Grundy - The Heart Research Institute, Sydney, New South Wales, Australia
Philip Barter - Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
Robert Mahley - American Hospital, Istanbul, Turkey
Robert Mahley - Department of Internal Medicine, University of Oulu, Oulu, Finland
Antero Kesaniemi - Biocenter Oulu, University of Oulu, Oulu, Finland
Antero Kesaniemi - Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Ruth McPherson - Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
John B Vincent, John Strauss & James L Kennedy - Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King′s College London, London, UK
Anne Farmer & Peter McGuffin - Division of Medical Sciences, Center for Neuroscience, University of Dundee, Dundee, UK
Richard Day & Keith Matthews - Institute of Medicine, University of Bergen, Bergen, Norway
Per Bakke & Amund Gulsvik - Max Planck Institute of Psychiatry, Munich, Germany
Susanne Lucae, Marcus Ising, Tanja Brueckl & Sonja Horstmann - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
H-Erich Wichmann, Rajesh Rawal & Claudia Lamina - Klinikum Grosshadern, Munich, Germany
H-Erich Wichmann - Psychiatrische Klinik und Poliklinik University of Mainz, Mainz, Germany
Norbert Dahmen - Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
Claudia Lamina - School of Public Health, School of Medicine, University of Zagreb, Croatia
Ozren Polasek & Ivana Kolcic - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
Lina Zgaga, James F Wilson, Sarah H Wild, Harry Campbell & Igor Rudan - Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, Edinburgh, UK
Jennifer Huffman, Susan Campbell, Veronique Vitart, Caroline Hayward & Alan F Wright - National Heart and Lung Institute, Imperial College London, London, UK
Jaspal Kooner - Division of Epidemiology, Imperial College London, London, UK
John C Chambers - Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC, USA
Mary Susan Burnett, Joseph M Devaney, Augusto D Pichard, Kenneth M Kent, Lowell Satler, Joseph M Lindsay, Ron Waksman & Stephen Epstein - The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Muredach P Reilly, Robert Wilensky, William Matthai & Daniel J Rader - The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Muredach P Reilly & Daniel J Rader - Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mingyao Li & Liming Qu - The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Hakon H Hakonarson - Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
Andre Franke, Michael Wittig & Arne Schäfer - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy
Manuela Uda & Fabio Busonero - National Institute on Aging, Baltimore, Maryland, USA
Antonio Terracciano & David Schlessinger - Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Xiangjun Xiao & Paul Scheet - Department of Mental Health, University of Aberdeen, Aberdeen, UK
David St Clair - Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany
Dan Rujescu - Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Gonçalo R Abecasis - Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
Hans Jörgen Grabe - Interfacultary Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany
Alexander Teumer - Institute for Community Medicine, University of Greifswald, Greifswald, Germany
Henry Völzke - Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany
Astrid Petersmann - Department of Social Medicine and Epidemiology, University of Greifswald, Greifswald, Germany
Ulrich John - Croatian Centre for Global Health, University of Split, Split, Croatia
Igor Rudan - Department of Health Sciences, University of Leicester, Leicester, UK
Benjamin J Wright & John R Thompson - Mulitdisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK
Anthony J Balmforth & Alistair S Hall - Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
Nilesh J Samani - Peninsula College of Medicine and Dentistry, Exeter, UK
Tariq Ahmad - Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, UK
Christopher G Mathew - Gastroenterology Research Unit, Addenbrooke's Hospital, Cambridge, UK
Miles Parkes - Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
Jack Satsangi - Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Mark Caulfield & Patricia B Munroe - Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, UK
Martin Farrall - Division of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Western Infirmary, Glasgow, UK.,
Anna Dominiczak - arc Epidemiology Research Unit, School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester, UK
Jane Worthington, Wendy Thomson, Steve Eyre & Anne Barton - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Clyde Francks
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Contributions
J.Z.L. carried out most of the analysis for this study. J.M. and C.F. conceived and directed this study and wrote the manuscript. F.T., D.M.W. and V.M. were involved in study design and helped to coordinate the inclusion of many of the GSK cohorts. S.G.P., P. Muglia, L.M., W.B., C.W.K., X.Y., G.W., P.V., M. Preisig, N.J.W., J.H.Z., R.J.F.L., I.B., K.-T.K., S.G., P. Barter, R. Mahley, A.K., R. McPherson, J.B.V., J. Strauss, J.L.K., A. Farmer, P. McGuffin, R.D., K.M., P. Bakke, A.G., S.L., M.I., T.B., S.H., H.-E.W., R.R., N.D., C.L., O.P., L.Z., J.H., S.C., J.K., J.C.C., M.S.B., J.M.D., A.D.P., K.M.K.. L.S., J.M.L., R. Waksman, S. Epstein, J.F.W., S.H.W., H.C., V.V., M.P.R., M.L., L.Q., R. Wilensky, W.M., H.H.H., D.J.R., A. Franke, M.W., A.S., M.U., A. Terracciano, X.X., F.B., P.S., D.S., D.St.C., D.R., G.R.A., H.J.G., A. Teumer, H.V., A.P., U.J., I.R., C.H., A.F.W., I.K., B.J.W., J.R.T., A.J.B., A.S.H., N.J.S., C.A.A., T.A., C.G.M., M. Parkes, J. Satsangi, M.C., P.B.M., M.F., A.D., J.W., W.T., S. Eyre, A.B. and W.T.C.C.C. prepared and shared data sets and, in some cases, cohort-specific results from their own primary analysis.
Corresponding authors
Correspondence toClyde Francks or Jonathan Marchini.
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Competing interests
F.T., C.F., D.M.W., V.M., P.M., S.G.P. and C.W.K either are or were full-time employees of the company GlaxoSmithKline (GSK). GSK also funded several aspects of the study as detailed in the ACKNOWLEDGMENTS section.
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A full list of members is provided in the Supplementary Note.
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Liu, J., Tozzi, F., Waterworth, D. et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity.Nat Genet 42, 436–440 (2010). https://doi.org/10.1038/ng.572
- Received: 19 October 2009
- Accepted: 18 March 2010
- Published: 25 April 2010
- Issue Date: May 2010
- DOI: https://doi.org/10.1038/ng.572