A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 (original) (raw)

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Acknowledgements

The authors thank all of the participants who took part in this research and the funders and support staff who made this study possible. We also thank R. Peto for his comments on the manuscript. Funding for the initial genome-wide study was provided by INCa, France. Additional funding for replication studies was provided by the US NCI (R01 CA092039) and the Ontario Institute for Cancer Research (OICR).

Author Contributions P.B. and M.L. designed the study. R.J.H., J.D.M., A.B. and H.B. coordinated the preparation and inclusion of all biological samples. R.J.H., J.D.M., V.G. and S.H. undertook the statistical analysis. Bioinformatics analysis was undertaken by F.M., M.F. and S.H., D.Z. and M.D. coordinated the genotyping of the central Europe samples, and J.D.M, R.J.H. and V.G. coordinated the genotyping of the other studies. All other co-authors coordinated the initial recruitment and management of the studies. M.L. obtained financial support for genotyping of the central Europe study, and P.B. and R.J.H. obtained financial support for genotyping of the other studies. P.B. and M.L. drafted the manuscript with substantial contributions from R.J.H. and J.D.M. All authors contributed to the final paper.

Author information

Author notes

  1. Rayjean J. Hung and James D. McKay: These authors contributed equally to this work.

Authors and Affiliations

  1. International Agency for Research on Cancer (IARC), Lyon 69008, France
    Rayjean J. Hung, James D. McKay, Valerie Gaborieau, Paolo Boffetta, Mia Hashibe, Pierre Hainaut & Paul Brennan
  2. School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA ,
    Rayjean J. Hung
  3. Institute of Carcinogenesis, Cancer Research Centre, Moscow 115478, Russia ,
    David Zaridze & Anush Mukeria
  4. Department of Epidemiology, Institute of Occupational Medicine, Lodz 90950, Poland
    Neonilia Szeszenia-Dabrowska
  5. M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02781, Poland
    Jolanta Lissowska
  6. National Institute of Environmental Health, Budapest 1097, Hungary
    Peter Rudnai
  7. Specialized Institute of Hygiene and Epidemiology, Banska Bystrica 97556, Slovakia
    Eleonora Fabianova
  8. Institute of Public Health, Bucharest 050463, Romania
    Dana Mates
  9. Charles University in Prague, First Faculty of Medicine, Institute of Hygiene and Epidemiology, Prague 2 12800, Czech Republic
    Vladimir Bencko
  10. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 65653, Czech Republic
    Lenka Foretova
  11. Palacky University, Olomouc 77515, Czech Republic
    Vladimir Janout
  12. Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA ,
    Chu Chen & Gary Goodman
  13. Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool L3 9TA, UK
    John K. Field, Triantafillos Liloglou, George Xinarianos & Adrian Cassidy
  14. Cancer Care Ontario, and the Samuel Lunenfeld Research Institute, Toronto M5G 2L7, Canada
    John McLaughlin
  15. Princess Margaret Hospital, Ontario Cancer Institute, Toronto M5G 2M9, Canada
    Geoffrey Liu
  16. Women’s College Research Institute, Toronto M5G 1N8, Canada
    Steven Narod
  17. Norwegian University of Science and Technology, Trondheim 7489, Norway
    Hans E. Krokan, Frank Skorpen, Maiken Bratt Elvestad, Kristian Hveem & Lars Vatten
  18. Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany,
    Jakob Linseisen
  19. INSERM ERI20, Institut Gustave Roussy, Villejuif 94805, France
    Françoise Clavel-Chapelon
  20. Department of Epidemiology and Public Health, Imperial College, London W2 1PG, UK
    Paolo Vineis & Elio Riboli
  21. Institute for Scientific Interchange (ISI), Torino 10133, Italy
    Paolo Vineis
  22. Centre for Nutrition and Health, National Institute of Public Health and the Environment, Bilthoven 3710 BA, The Netherlands
    H. Bas Bueno-de-Mesquita
  23. Institute of Community Medicine, University of Tromsö, Tromsö 9037, Norway
    Eiliv Lund
  24. Andalusian school of Public Health and Ciber Epidemiology y Salud Publica, Granada 18011, Spain
    Carmen Martinez
  25. Department of Public Health and Primary Care and MRC Dunn Human Nutrition Unit, MRC Centre for Nutrition and Cancer, University of Cambridge, Cambridge CB2 0XY, UK
    Sheila Bingham
  26. Department of Radiation Sciences, Oncology, Umea University, Umea 90187, Sweden
    Torgny Rasmuson
  27. Epidemiological Methods and Etiologic Research, Bremen Institute for Prevention Research and Social Medicine, Bremen 28359, Germany
    Wolfgang Ahrens
  28. INSERM U794, Fondation Jean Dausset-CEPH, Paris 75010, France ,
    Simone Benhamou
  29. CNRS FRE2939, Institute Gustave Roussy, Villejuif 94805, France
    Simone Benhamou
  30. Department of Hygiene and Epidemiology, and Department of Epidemiology, University of Athens School of Medicine, Athens 11527, Greece, Harvard School of Public Health, Boston, Massachusetts 02115, USA,
    Pagona Lagiou & Dimitrios Trichopoulos
  31. Institute of Hygiene and Epidemiology, Prague 2 12800, Czech Republic
    Ivana Holcátová
  32. University of Turin, Turin 10126, Italy
    Franco Merletti
  33. Cancer registry of Norway, Oslo 0310, Norway
    Kristina Kjaerheim
  34. Institut Català d’Oncologia, Barcelona 08907, Spain
    Antonio Agudo
  35. University of Aberdeen School of Medicine, Aberdeen AB25 2ZD, UK
    Gary Macfarlane
  36. Aviano cancer center, Aviano 33081, Italy
    Renato Talamini
  37. Department of Environmental Medicine and Public Health, University of Padua, Padua 35131, Italy
    Lorenzo Simonato
  38. University of Newcastle Dental School, Newcastle NE2 4BW, UK
    Ray Lowry
  39. University of Glasgow Dental School, Glasgow G2 3JZ, UK
    David I. Conway
  40. Croatian National Cancer Registry, National Institute of Public Health, Zagreb 10000, Croatia
    Ariana Znaor
  41. Trinity College School of Dental Science, Dublin 2, Ireland
    Claire Healy
  42. Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France ,
    Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Fumihiko Matsuda, Ivo Gut & Mark Lathrop
  43. Fondation Jean Dausset-CEPH, Paris 75010, France
    Helene Blanche, Simon Heath & Mark Lathrop

Authors

  1. Rayjean J. Hung
  2. James D. McKay
  3. Valerie Gaborieau
  4. Paolo Boffetta
  5. Mia Hashibe
  6. David Zaridze
  7. Anush Mukeria
  8. Neonilia Szeszenia-Dabrowska
  9. Jolanta Lissowska
  10. Peter Rudnai
  11. Eleonora Fabianova
  12. Dana Mates
  13. Vladimir Bencko
  14. Lenka Foretova
  15. Vladimir Janout
  16. Chu Chen
  17. Gary Goodman
  18. John K. Field
  19. Triantafillos Liloglou
  20. George Xinarianos
  21. Adrian Cassidy
  22. John McLaughlin
  23. Geoffrey Liu
  24. Steven Narod
  25. Hans E. Krokan
  26. Frank Skorpen
  27. Maiken Bratt Elvestad
  28. Kristian Hveem
  29. Lars Vatten
  30. Jakob Linseisen
  31. Françoise Clavel-Chapelon
  32. Paolo Vineis
  33. H. Bas Bueno-de-Mesquita
  34. Eiliv Lund
  35. Carmen Martinez
  36. Sheila Bingham
  37. Torgny Rasmuson
  38. Pierre Hainaut
  39. Elio Riboli
  40. Wolfgang Ahrens
  41. Simone Benhamou
  42. Pagona Lagiou
  43. Dimitrios Trichopoulos
  44. Ivana Holcátová
  45. Franco Merletti
  46. Kristina Kjaerheim
  47. Antonio Agudo
  48. Gary Macfarlane
  49. Renato Talamini
  50. Lorenzo Simonato
  51. Ray Lowry
  52. David I. Conway
  53. Ariana Znaor
  54. Claire Healy
  55. Diana Zelenika
  56. Anne Boland
  57. Marc Delepine
  58. Mario Foglio
  59. Doris Lechner
  60. Fumihiko Matsuda
  61. Helene Blanche
  62. Ivo Gut
  63. Simon Heath
  64. Mark Lathrop
  65. Paul Brennan

Corresponding author

Correspondence toPaul Brennan.

Supplementary information

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The file contains Supplementary Methods, Supplementary Discussion with additional references, Supplementary Figures 1-6 with Legends and Supplementary Tables 1-5. (PDF 2062 kb)

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Hung, R., McKay, J., Gaborieau, V. et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.Nature 452, 633–637 (2008). https://doi.org/10.1038/nature06885

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