Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease (original) (raw)

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Acknowledgements

This work was funded by the Walloon Region (IPSEQ, Crohn & CIBLES projects), by the Politique Scientifique Fédérale (IAP GENFUNC), by the Fonds National de la Recherche Scientifique (FNRS) and by the Communauté Française de Belgique (ARC BIOMOD). E.L. is a senior research associate from the FNRS. K.N. benefitted from a post-doctoral fellowship from the University of Liège. We are grateful to A. Kvasz, F. Farnir and D. Baurain for their help with bioinformatic analyses. We thank the personnel of the Flanders Institute for Biotechnology (VIB) Genetic Service Facility (http://www.vibgeneticservicefacility.be) and the GIGA-R genotranscriptomic platform for their contribution to sequencing. We are grateful to N. Wray and P. Visscher for fruitful discussions.

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Authors and Affiliations

1. Unit of Animal Genomics, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-R) and Faculty of Veterinary Medicine, University of Liège (B34), Liège, Belgium
   Yukihide Momozawa, Myriam Mni, Kayo Nakamura, Wouter Coppieters, Cécile Libioulle & Michel Georges
2. Division of Gastroenterology and Hepatology, Institutionen för molekylär och klinisk medicin (IMK) Linköpings Universitet, Linköping, Sweden
   Sven Almer
3. Department of Gastroenterology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium
   Leila Amininejad & Denis Franchimont
4. Department of Pathophysiology, Gastroenterology Section, Catholic University of Leuven, Leuven, Belgium
   Isabelle Cleynen, Paul Rutgeerts & Severine Vermeire
5. Registre des MICI du Nord-Quest de la France (EPIMAD), Hôpital Calmette, Lille, France
   Jean-Frédéric Colombel
6. Department of Molecular Genetics, Applied Molecular Genomics, Vlaams Instituut voor Biotechnologie (VIB), University of Antwerp, Antwerp, Belgium
   Peter de Rijk, Dirk Goossens & Jurgen Del-Favero
7. Department of Gastroenterology, Clinique Universitaire St Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
   Olivier Dewit
8. Department of Gastroenterology, Karolinska Children's Hospital, Stockholm, Sweden
   Yigael Finkel
9. Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
   Miquel A Gassull
10. Department of Gastroenterology, University Hospital, Ghent University, Ghent, Belgium
    Debby Laukens & Martine de Vos
11. Department of Gastroenterology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Université Paris Diderot Paris-VII, Paris, France
    Marc Lémann
12. Adelaide and Meath Hospital, Dublin, Ireland
    Colm O'Morain
13. Unit of Hepato-gastroenterology, GIGA-R and Faculty of Medicine, University of Liège (B34), Liège, Belgium
    Catherine Reenaers & Edouard Louis
14. Department of Gastroenterology, Örebro Medical Center Hospital, Örebro, Sweden
    Curt Tysk
15. Centre National de Génotypage, Evry, France
    Diana Zelenika & Mark Lathrop
16. INSERM U843, Hopital Robert Debré, Paris, France
    Jean-Pierre Hugot

Authors

1. Yukihide Momozawa
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2. Myriam Mni
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3. Kayo Nakamura
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4. Wouter Coppieters
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5. Sven Almer
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6. Leila Amininejad
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7. Isabelle Cleynen
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8. Jean-Frédéric Colombel
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9. Peter de Rijk
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10. Olivier Dewit
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11. Yigael Finkel
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12. Miquel A Gassull
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13. Dirk Goossens
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14. Debby Laukens
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15. Marc Lémann
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16. Cécile Libioulle
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17. Colm O'Morain
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18. Catherine Reenaers
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19. Paul Rutgeerts
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20. Curt Tysk
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21. Diana Zelenika
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22. Mark Lathrop
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23. Jurgen Del-Favero
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24. Jean-Pierre Hugot
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25. Martine de Vos
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26. Denis Franchimont
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27. Severine Vermeire
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28. Edouard Louis
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29. Michel Georges
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Contributions

Y.M., M.M., K.N., L.A., D.G. and D.Z. performed experiments. Y.M., W.C., P.d.R. and M.G. analyzed data. M. Lathrop and J.D.-F. supervised experiments. S.A., L.A., J.-F.C., O.D., Y.F., M.A.G., M. Lémann, C.O., C.R., P.R., C.T., J.-P.H., M.d.V., D.F., S.V. and E.L. examined cases and collected samples. I.C., D.L. and C.L. prepared and organized samples. Y.M. and M.G. wrote the manuscript.

Corresponding author

Correspondence toMichel Georges.

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The authors declare no competing financial interests.

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Momozawa, Y., Mni, M., Nakamura, K. et al. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease.Nat Genet 43, 43–47 (2011). https://doi.org/10.1038/ng.733

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• Received: 03 August 2010
• Accepted: 18 November 2010
• Published: 12 December 2010
• Issue Date: January 2011
• DOI: https://doi.org/10.1038/ng.733