Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci (original) (raw)

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Acknowledgements

SLEGEN appreciates the financial support of the Alliance for Lupus Research. Other support was obtained individually from the Alliance for Lupus Research (J.B.H., K.L.M., C.O.J.), the US National Institutes of Health (grants RR020278 (S.B.G.), AR62277 (J.B.H.), RR020143 (J.B.H.), AR24260 (J.B.H.), AI24717 (J.B.H.), AR22804 (L.A.C.), AR02175 (L.A.C.), AR052300 (L.A.C.), AR43815 (C.O.J.), AR49084 (R.P.K.), AR33062 (R.P.K.), AR43247 (K.L.M.) and AR43814 (B.P.T.)), the Mary Kirkland Awards (J.B.H., L.A.C.), the US Department of Veterans Affairs (J.B.H.), the Lupus Foundation of Minnesota (K.L.M.), the Knut and Alice Wallenberg Foundation (M.E.A.-R.), the Torsten & Ragnar Söderbergs Foundation (M.E.A.-R.), the Swedish Research Council (M.E.A.-R.) and a Wellcome Trust Senior Fellowship (T.J.V.). Additional acknowledgments are listed in the Supplementary Note online.

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Author notes

1. Broad Institute, 7 Cambridge Center, Boston, Massachusetts 02142 USA.
2. Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, New York 11030, USA.
3. Genentech, Inc.,1 DNA Way, South San Francisco, California 94080, USA.
4. University of California at Riverside, 900 University Avenue, Riverside, California 92521, USA.
5. Université de Montréal, 5000 rue Belanger, Montréal H1T 1C8, Canada.
6. Medical University of South Carolina, 135 Rutledge Avenue, Charleston, South Carolina 29403, USA.
7. University of California at Davis, 1 Shields Avenue, Davis, California 95616, USA.
8. University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA.

Authors and Affiliations

1. Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, 73104, Oklahoma, USA
   John B Harley & Kathy L Moser
2. US Department of Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, 73104, Oklahoma, USA
   John B Harley
3. University of Oklahoma Health Sciences Center, 1100 N Lindsey, Oklahoma City, 73104, Oklahoma, USA
   John B Harley
4. University of Uppsala, Olofsgatan St 10B, Uppsala, SE-751 05, Sweden
   Marta E Alarcón-Riquelme
5. University of California at San Francisco, 374 Parnassus Ave, San Francisco, 94143, California, USA
   Lindsey A Criswell
6. University of Southern California, 2011 Zonal Avenue, Los Angeles, 90033, California, USA
   Chaim O Jacob
7. University of Alabama at Birmingham, 1900 University Blvd., Birmingham, 35294, Alabama, USA
   Robert P Kimberly
8. University of Minnesota, 312 Church Street, Minneapolis, 55455, Minnesota, USA
   Kathy L Moser
9. University of California at Los Angeles, 1000 Veterans Avenue, Los Angeles, 90095, California, USA
   Betty P Tsao
10. Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Timothy J Vyse
11. Wake Forest University Health Sciences, Medical Center Blvd., Winston-Salem, 27157, North Carolina, USA
    Carl D Langefeld

Authors

1. John B Harley
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2. Marta E Alarcón-Riquelme
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3. Lindsey A Criswell
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4. Chaim O Jacob
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5. Robert P Kimberly
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6. Kathy L Moser
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7. Betty P Tsao
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8. Timothy J Vyse
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9. Carl D Langefeld
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Consortia

The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)

Contributions

J.B.H., C.D.L. and J.A.K. wrote the manuscript. M.E.A.-R., L.A.C., C.O.J., R.P.K., K.L.M., B.P.T., T.J.V. and J.C.E. evaluated the manuscript for content. S.B.G., D.B.M., K.M.K., Q.-Z.L., E.K.W., S.G.F., A.T.L., P.K.G., G.R.B., J.O.O., S.K.N., J.M.G., B.L.C. and B.N. collected or contributed data. C.D.L., M.C.M., A.H.W., W.W., J.A.K., J.D., K.E.T., R.Z. and M.F.S. performed analyses overseen by the data analysis committee (C.D.L., R.Z., P.M.G., J.C.E., J.D.R., K.M.K., M.E.A.-R., M.F., K.E.T. and B.P.T.). J.B.H., C.D.L., K.M.K., T.W.B., J.A.K., M.E.A.-R., L.A.C., C.O.J., R.P.K., K.L.M., B.P.T., T.J.V., S.K.N. and J.M.G. are responsible for the study design. J.B.H., M.E.A.-R., L.A.C., C.O.J., R.P.K., K.L.M., B.P.T., T.J.V., T.W.B., P.K.G., P.M.G., J.A.J., J.T.M., G.S.G., H.Y., E.C.B. and G.R.B. provided samples.

Other contributing authors are as follows:

Swapan K Nath1, Joel M Guthridge1, Beth L Cobb1, Daniel B Mirel12, Miranda C Marion10, Adrienne H Williams10, Jasmin Divers10, Wei Wang10, Summer G Frank1, Bahram Namjou1, Stacey B Gabriel12, Annette T Lee13, Peter K Gregersen13, Timothy W Behrens7,14, Kimberly E Taylor4, Michelle Fernando9, Raphael Zidovetzki15, Patrick M Gaffney1,7, Jeffrey C Edberg6, John D Rioux16, Joshua O Ojwang1, Judith A James1, Joan T Merrill1, Gary S Gilkeson17, Michael F Seldin18, Hong Yin3, Emily C Baechler7, Quan-Zhen Li19, Edward K Wakeland19, Gail R Bruner1, Kenneth M Kaufman1,2 & Jennifer A Kelly1

Corresponding authors

Correspondence toJohn B Harley or Carl D Langefeld.

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Competing interests

SLEGEN has submitted a patent application based upon these results.

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SLEGEN members are listed above; other contributing authors are listed at the end of the paper.

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The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)., Harley, J., Alarcón-Riquelme, M. et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.Nat Genet 40, 204–210 (2008). https://doi.org/10.1038/ng.81

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• Received: 02 October 2007
• Accepted: 18 December 2007
• Published: 20 January 2008
• Issue Date: February 2008
• DOI: https://doi.org/10.1038/ng.81