Increased exonic de novo mutation rate in individuals with schizophrenia (original) (raw)

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References

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Acknowledgements

Subjects were selected from the Psydev study, promoted by INSERM, through the Collaborative Network for Family Study in Psychiatry ('Réseau d'étude familiale en Psychiatry', REFAPSY), supported by the Fondation Pierre Deniker. We wish to thank S. Bannour, M.-J. Dos Santos, M.A. Gorsane, N. Benjemaa, M. Chayet, S. Leroy, F. Mouaffak, K. Ossian and F. Polides for participating in recruitment of subjects and for their technical help. This work was supported by Genome Canada and Génome Québec and received co-funding from Université de Montréal for the Synapse to Disease (S2D) project as well as funding from the Canadian Foundation for Innovation, Brain & Behavior Research Foundation. Bioinformatic analysis was supported by a Canadian Institutes of Health Research (CIHR) Team grant (RMF92086). G.A.R. is grateful for the support received through his positions as Canada Research Chair in Genetics of the Nervous System and Jeanne-et-J.-Louis-Levesque Chair for the Genetics of Brain Diseases. N. Jaafari was supported by an award, bourse chercheur invité, of the Région Poitou-Charente.

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Author notes

  1. Marie-Odile Krebs and Guy A Rouleau: These authors contributed equally to this work.

Authors and Affiliations

  1. Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de l'Université de Montréal Research Center, Montréal, Québec, Canada
    Simon L Girard, Julie Gauthier, Anne Noreau, Lan Xiong, Sirui Zhou, Loubna Jouan, Alexandre Dionne-Laporte, Dan Spiegelman, Edouard Henrion, Ousmane Diallo, Pascale Thibodeau, Patrick A Dion & Guy A Rouleau
  2. Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, Québec, Canada
    Isabelle Bachand & Guy A Rouleau
  3. Genome Research Centre, The Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Jessie Y J Bao, Amy Hin Yan Tong, Chi-Ho Lin & Si Lok
  4. INSERM, Université Paris Descartes, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences (UMR 894), Paris, France
    Bruno Millet, Nematollah Jaafari & Marie-Odile Krebs
  5. Université Rennes 1, CH Guillaume Régnier Service Hospitalo-Universitaire de Psychiatrie, Rennes, France
    Bruno Millet
  6. Université de Poitiers, CHU, Centre Hospitalier Henri Laborit, Unité de recherche clinique intersectorielle en psychiatrie, INSERM CIC-P 0802, Poitiers, France
    Nematollah Jaafari
  7. Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, Québec, Canada
    Ridha Joober
  8. Department of Pathology and Cellular Biology, Université de Montréal, Montréal, Québec, Canada
    Patrick A Dion
  9. Université Paris Descartes, Faculté de Médecine Paris Descartes, Service Hospitalo Universitaire, Centre Hospitalier Sainte-Anne, Paris, France
    Marie-Odile Krebs
  10. Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
    Guy A Rouleau

Authors

  1. Simon L Girard
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  2. Julie Gauthier
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  3. Anne Noreau
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  4. Lan Xiong
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  5. Sirui Zhou
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  6. Loubna Jouan
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  7. Alexandre Dionne-Laporte
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  8. Dan Spiegelman
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  9. Edouard Henrion
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  10. Ousmane Diallo
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  11. Pascale Thibodeau
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  12. Isabelle Bachand
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  13. Jessie Y J Bao
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  14. Amy Hin Yan Tong
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  15. Chi-Ho Lin
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  16. Bruno Millet
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  17. Nematollah Jaafari
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  18. Ridha Joober
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  19. Patrick A Dion
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  20. Si Lok
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  21. Marie-Odile Krebs
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  22. Guy A Rouleau
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Contributions

J.G., L.X., S.L.G. and G.A.R. designed the study. M.-O.K., L.X., B.M., R.J. and N.J. recruited cases and collected clinical information. I.B. and A.H.Y.T. performed exome capture and sequencing. S.L.G., D.S., J.Y.J.B. and C.-H.L. performed alignments and variant detection. A.N., S.Z., L.J., S.L.G. and P.T. performed variant validation. S.L.G., A.D.-L., D.S., E.H., O.D., A.H.Y.T., J.Y.J.B., C.-H.L. and S.L. performed bioinformatic analyses. S.L.G., P.A.D., M.-O.K., S.L. and G.A.R. wrote the paper.

Corresponding author

Correspondence toGuy A Rouleau.

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The authors declare no competing financial interests.

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Girard, S., Gauthier, J., Noreau, A. et al. Increased exonic de novo mutation rate in individuals with schizophrenia.Nat Genet 43, 860–863 (2011). https://doi.org/10.1038/ng.886

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