A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis (original) (raw)

References

  1. Menter, A. & Barker, J. Psoriasis in practice. Lancet 338, 231–234 (1991).
    Article CAS Google Scholar
  2. Duvic, M. Immunology of AIDS related to psoriasis. J. Invest. Dermatol. 95, 38S–40S (1990).
    Article Google Scholar
  3. National Psoriasis Foundation Bulletin. Psoriatic arthritis more common than suspected. 33, 6 (2002).
  4. Tiilikainen, A., Lassus, A., Karvonen, J., Vartiainen, P. & Julin, M. Psoriasis and HLA-Cw6. Brit. J. Dermatol. 102, 179–184 (1980).
    Article CAS Google Scholar
  5. Nair, R.P. et al. Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am. J. Hum. Genet. 66, 1833–1844 (2000).
    Article CAS Google Scholar
  6. Capon, F., Munro, M., Barker, J. & Trembath, R. Searching for the major histocompatibility complex psoriasis susceptibility gene. J. Invest. Dermatol. 118, 745–751 (2002).
    Article CAS Google Scholar
  7. Tomfohrde, J. et al. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 264, 1141–1145 (1994).
    Article CAS Google Scholar
  8. Nair, R.P. et al. Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum. Molec. Genet. 6, 1349–1356 (1997).
    Article CAS Google Scholar
  9. Enlund, F. et al. Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q. Hum. Hered. 49, 2–8 (1999).
    Article CAS Google Scholar
  10. Bowcock, A.M. & Barker, J. Genetics of psoriasis: the potential impact on new therapies. J. Am. Acad. Dermatol. 49, S51–S56 (2003).
    Article Google Scholar
  11. Reczek, D., Berryman, M. & Bretscher, A. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J. Cell Biol. 139, 169–179 (1997).
    Article CAS Google Scholar
  12. Itoh, K. et al. Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J. Immunol. 168, 541–544 (2002).
    Article CAS Google Scholar
  13. Kim, D.H. et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163–175 (2002).
    Article CAS Google Scholar
  14. Hara, K. et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177–189 (2002).
    Article CAS Google Scholar
  15. Prokunina, L. et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat. Genet. 32, 666–669 (2002).
    Article CAS Google Scholar
  16. Speckman, R.A. et al. Novel immunoglobulin superfamily gene cluster mapping to a region of human chromosome 17q25 harboring a locus for psoriasis susceptibility. Hum. Genet. 112, 31–41 (2002).
    Google Scholar
  17. Bickeboller, H. & Clerget-Darpoux, F. Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers. Genet. Epidemiol. 12, 865–870 (1995).
    Article CAS Google Scholar
  18. Martin, E.R., Monks, S.A., Warren, L.L. & Kaplan, N.L. A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am. J. Hum. Genet. 67, 146–154 (2000).
    Article CAS Google Scholar
  19. Lacaud, G. et al. Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood 100, 458–466 (2002).
    Article CAS Google Scholar
  20. Erickson, P. et al. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80, 1825–1831 (1992).
    CAS PubMed Google Scholar
  21. Rudd, P.M., Elliott, T., Cresswell, P., Wilson, I.A. & Dwek, R.A. Glycosylation and the immune system. Science 291, 2370–2376 (2001).
    Article CAS Google Scholar
  22. Daniels, M.A., Hogquist, K.A. & Jameson, S.C. Sweet 'n' sour: the impact of differential glycosylation on T cell responses. Nat. Immunol. 3, 903–910 (2002).
    Article CAS Google Scholar
  23. Demetriou, M., Granovsky, M., Quaggin, S. & Dennis, J.W. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature. 409, 733–739 (2001).
    Article CAS Google Scholar
  24. Renkonen, J., Tynninen, O., Hayry, P., Paavonen, T. & Renkonen, R. Glycosylation might provide endothelial zip codes for organ-specific leukocyte traffic into inflammatory sites. Am. J. Path. 161, 543–550 (2002).
    Article CAS Google Scholar
  25. Voltz, J.W., Weinman, E.J. & Shenolikar, S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene 20, 6309–6314 (2001).
    Article CAS Google Scholar
  26. Taniuchi, I. et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621–633 (2002).
    Article CAS Google Scholar
  27. Cookson, W.O. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat. Genet. 27, 372–373 (2001).
    Article CAS Google Scholar
  28. Gordon, D., Heath, S.C., Liu, X. & Ott, J. A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. Am. J. Hum. Genet. 69, 371–380 (2001).
    Article CAS Google Scholar
  29. Wijsman, E.M. A deductive method of haplotype analysis in pedigrees. Am. J. Hum. Genet. 41, 356–373 (1987).
    CAS PubMed PubMed Central Google Scholar
  30. Benjamini, Y., Drai, D., Elmer, G., Kafkafi, N. & Golani, I. Controlling the false discovery rate in behavior genetics research. Behav. Brain Res. 125, 279–284 (2001).
    Article CAS Google Scholar

Download references