Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms (original) (raw)

Nature Genetics volume 37, pages 588–589 (2005)Cite this article

Abstract

Gene duplication and alternative splicing are distinct evolutionary mechanisms that provide the raw material for new biological functions. We explored their relationships in human and mouse and found an inverse correlation between the size of a gene's family and its use of alternatively spliced isoforms. A cross-organism analysis suggests that selection for genome-wide genic proliferation might be interchangeably met by either evolutionary mechanism.

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Acknowledgements

We thank A. Derti for a critical reading of the manuscript and Y. Groner, E. Domany, M.J. Lercher, A. Bar-Even and S.J. Fleishman for discussions. I.Y. is a Koshland Scholar and D.L. is the incumbent of the Ralph and Lois Silver Chair in Human Genomics. This research is supported by the Crown Human Genome Center, the Abraham and Judith Goldwasser Foundation and the Koshland Center for Basic Research.

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  1. Itai Yanai
    Present address: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, 02138, USA

Authors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Naama M Kopelman, Doron Lancet & Itai Yanai

Authors

  1. Naama M Kopelman
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  2. Doron Lancet
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  3. Itai Yanai
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Correspondence toItai Yanai.

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Kopelman, N., Lancet, D. & Yanai, I. Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms.Nat Genet 37, 588–589 (2005). https://doi.org/10.1038/ng1575

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