Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility (original) (raw)

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Acknowledgements

We acknowledge use of DNA from the 1958 British Birth Cohort collection (R. Jones, S. Ring, W. McArdle and M. Pembrey), funded by the UK MRC (grant G0000934) and The Wellcome Trust (grant 068545/Z/02). We also acknowledge the National Association for Colitis and Crohn's disease and the Wellcome Trust for supporting the case DNA collections and UCB Pharma for supporting this study with an unrestricted educational grant. We thank D. Kelberman, all subjects who contributed samples and consultants and nursing staff across the UK who helped with recruitment of study subjects.

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Author notes

  1. Miles Parkes, Jeffrey C Barrett and Natalie J Prescott: These authors contributed equally to this work.

Authors and Affiliations

  1. Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Miles Parkes & Mark Tremelling
  2. Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Jeffrey C Barrett, Carl A Anderson & Lon Cardon
  3. Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, SE1 9RT, UK
    Natalie J Prescott, Sheila A Fisher, Roland G Roberts, Dianne Soars, Saud A Khawaja, Richard Bagnall, Clive M Onnie, Cathryn M Lewis & Christopher G Mathew
  4. Division of Medical Sciences, Gastrointestinal Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Elaine R Nimmo, Hazel Drummond, Charlie W Lees & Jack Satsangi
  5. Gastroenterology Unit, Radcliffe Infirmary, University of Oxford, Oxford, OX2 6HE, UK
    Fraser R Cummings, Tariq Ahmad & Derek P Jewell
  6. Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Denis A Burke, Catherine E Todhunter & John C Mansfield
  7. Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK
    Wendy McArdle
  8. Division of Community Health Services, St George's University of London, Cranmer Terrace, London, SW17 ORE, UK
    David Strachan
  9. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Graeme Bethel, Claire Bryan & Panos Deloukas
  10. Institute for Digestive Diseases, University College London Hospitals Trust, London, NW1 2BU, UK
    Alastair Forbes
  11. Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK
    Jeremy Sanderson

Authors

  1. Miles Parkes
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  2. Jeffrey C Barrett
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  3. Natalie J Prescott
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  4. Mark Tremelling
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  5. Carl A Anderson
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  6. Sheila A Fisher
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  7. Roland G Roberts
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  8. Elaine R Nimmo
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  9. Fraser R Cummings
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  10. Dianne Soars
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  11. Hazel Drummond
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  12. Charlie W Lees
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  13. Saud A Khawaja
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  14. Richard Bagnall
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  15. Denis A Burke
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  16. Catherine E Todhunter
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  17. Tariq Ahmad
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  18. Clive M Onnie
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  19. Wendy McArdle
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  20. David Strachan
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  21. Graeme Bethel
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  22. Claire Bryan
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  23. Cathryn M Lewis
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  24. Panos Deloukas
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  25. Alastair Forbes
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  26. Jeremy Sanderson
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  27. Derek P Jewell
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  28. Jack Satsangi
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  29. John C Mansfield
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  30. Lon Cardon
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  31. Christopher G Mathew
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Consortia

the Wellcome Trust Case Control Consortium

Contributions

M.P., J.S., J.C.M., D.P.J. and C.G.M. are principal investigators for the five participating centers; E.R.N., C.B. and P.D. did DNA extraction, normalization and quality control; W.M. and D.S. supplied control DNA samples; M.T., F.R.C., H.D., C.W.L., S.A.K., C.E.T., T.A., C.M.O., A.F. and J.S. recruited study subjects and extracted phenotype data; N.J.P., R.G.R., R.B., D.A.B. undertook genotyping and sequence analysis and G.B. performed expression analysis; J.C.B., C.A.A., S.A.F., C.M.L. and L.C. undertook the statistical analysis; WTCCC provided initial data for Crohn's disease and other case-control panels and M.P., J.C.B. and C.G.M. wrote the manuscript. Members of the WTCCC are listed in the Supplementary Note online.

Corresponding author

Correspondence toMiles Parkes.

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The authors declare no competing financial interests.

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Parkes, M., Barrett, J., Prescott, N. et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.Nat Genet 39, 830–832 (2007). https://doi.org/10.1038/ng2061

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