BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2 (original) (raw)
References
Kantarjian, H.M., Deisseroth, A., Kurzrock, R., Estrov, Z. & Talpaz, M. Chronic myelogenous leukemia: a concise update. Blood82, 691–703 (1993). CAS Google Scholar
Gordon, M.Y. Biological consequences of the BCR-ABL fusion gene in humans and mice. J. Clin. Pathol.52, 719–722 (1999). ArticleCAS Google Scholar
Sawyers, C.L. Chronic myeloid leukemia. N. Engl. J. Med.340, 1330–1340 (1999). ArticleCAS Google Scholar
Carlesso, N., Frank, D.A. & Griffin, J.D. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by BCR-ABL. J. Exp. Med.183, 811–820 (1996). ArticleCAS Google Scholar
Perrotti, D. et al. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR-ABL-mediated leukemogenesis. EMBO J.17, 4442–4455 (1998). ArticleCAS Google Scholar
Ward, A.C., Loeb, D.M., Soede-Bobok, A.A., Touw, I.P. & Friedman, A.D. Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia14, 973–990 (2000). ArticleCAS Google Scholar
Orkin, S.H. Diversification of hematopoietic stem cells to specific lineages. Nature Rev. Genet.1, 57–64 (2000). ArticleCAS Google Scholar
Zhang, D. E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl Acad. Sci. USA94, 569–574 (1997). ArticleCAS Google Scholar
Radomska, H.S. et al. CCAAT enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol.18, 4301–4314 (1998). ArticleCAS Google Scholar
Smith, L.T., Hohaus, S., Gonzalez, D.A., Dziennis, S.E. & Tenen, D.G. PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony- stimulating factor receptor promoter in myeloid cells. Blood88, 1234–1247 (1996). CAS Google Scholar
Wang, X., Scott, E., Sawyers, C.L. & Friedman, A.D. C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32Dcl3 myeloblasts. Blood94, 560–571 (1999). CAS Google Scholar
Scott, L.M., Civin, C.I., Rorth, P. & Friedman, A.D. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood80, 1725–1735 (1992). CAS Google Scholar
Cheng, T. et al. Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells. Proc. Natl Acad. Sci. USA93, 13158–13162 (1996). ArticleCAS Google Scholar
Kozak, M. Initiation of translation in prokaryotes and eukaryotes. Gene234, 187–208 (1999). ArticleCAS Google Scholar
Lekstrom-Himes, J. & Xanthopoulos, K.G. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J. Biol. Chem.273, 28545–28548 (1998). ArticleCAS Google Scholar
Lincoln, A.J., Monczak, Y., Williams, S.C. & Johnson, P.F. Inhibition of CCAAT/enhancer-binding proteinα and β translation by upstream open reading frames. J. Biol. Chem.273, 9552–9560 (1998). ArticleCAS Google Scholar
Laneuville, P., Heisterkamp, N. & Groffen, J. Expression of the chronic myelogenous leukemia-associated p210BCR-ABL oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene6, 275–282 (1991). CAS Google Scholar
Steinman, R.A. & Tweardy, D.J. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood83, 119–127 (1994). CAS Google Scholar
Tkatch, L.S., Rubin, K.A., Ziegler, S.F. & Tweardy, D.J. Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. J. Leukoc. Biol.57, 964–971 (1995). ArticleCAS Google Scholar
Lin, F.T., MacDougald, O.A., Diehl, A.M. & Lane, M.D. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: transcriptional activator lacking antimitotic activity. Proc. Natl Acad. Sci. USA90, 9606–9610 (1993). ArticleCAS Google Scholar
Ossipow, V., Descombes, P. & Schibler, U. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc. Natl Acad. Sci. USA90, 8219–8223 (1993). ArticleCAS Google Scholar
Calkhoven, C.F., Muller, C. & Leutz, A. Translational control of C/EBPα and C/EBPβ isoforms expression. Genes Dev.14, 1920–1932 (2000). CAS Google Scholar
van der Velden, A.W. & Thomas, A.A. The role of the 5′ untranslated region of an mRNA in translation regulation during development. Int. J. Biochem. Cell. Biol.31, 87–106 (1999). Article Google Scholar
Kozak, M. Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. Proc. Natl Acad. Sci. USA92, 2662–2666 (1995). ArticleCAS Google Scholar
Ostareck-Lederer, A., Ostareck, D.H. & Hentze, M. W. Cytoplasmic regulatory functions of the KH-domain proteins hnRNP K and E1/E2. Trends Biochem. Sci.23, 409–411 (1998). ArticleCAS Google Scholar
Zou, X. & Calame, K. Signaling pathways activated by oncogenic forms of Abl tyrosine kinase. J. Biol. Chem.274, 18141–18144 (1999). ArticleCAS Google Scholar
Zhang, D.E. et al. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr. Top. Microbiol. Immunol.211, 137–147 (1996). CAS Google Scholar
Bellon, T., Perrotti, D. & Calabretta, B. Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter. Blood90, 1828–1839 (1997). CAS Google Scholar
Gaiger, A. et al. Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression. Blood86, 2371–2378 (1995). CAS Google Scholar
Elmaagacli, A.H., Beelen, D.W., Opalka, B., Seeber, S. & Schaefer, U.W. The amount of BCR-ABL fusion transcripts detected by the real-time quantitative polymerase chain reaction method in patients with Philadelphia chromosome positive chronic myeloid leukemia correlates with the disease stage. Annu. Hematol.79, 424–431 (2000). ArticleCAS Google Scholar
Kantarjian, H.M. et al. Chronic myelogenous leukemia in blast crisis: analysis of 242 patients. Am. J. Med.83, 445–454 (1987). ArticleCAS Google Scholar
Cambier, N., Chopra, R., Strasser, A., Metcalf, D. & Elefanty, A.G. BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner. Oncogene16, 335–348 (1998). ArticleCAS Google Scholar
Issaad, C. et al. Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7. Leukemia14, 662–670 (2000). ArticleCAS Google Scholar
Pabst, T. et al. AML-1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nature Med.7, 444–451 (2001). ArticleCAS Google Scholar
Wong, K.K et al. v-Abl activates c-myc transcription through the E2F site. Mol. Cell. Biol.15, 6535–6544 (1995). ArticleCAS Google Scholar
Dai, Z. et al. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes Dev.12, 1415–1424 (1998). ArticleCAS Google Scholar
Perrotti, D. et al. BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CβII-dependent pathway. Mol. Cell. Biol.20, 6159–6169 (2000). ArticleCAS Google Scholar
Ilaria, R.L. Jr, Hawley, R.G. & Van Etten, R.A. Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation. Blood93, 4154–4166 (1999). CAS Google Scholar
Cazzola, M. & Skoda, R.C. Translational pathophysiology: a novel molecular mechanism of human disease. Blood95, 3280–3288 (2000). CAS Google Scholar
Thisted, T., Lyakhov, D.L. & Liebhaber, S.A. Optimized RNA targets of two closely-related triple KH-domains proteins, hnRNP K and aCP-2KL, suggest distinct modes of RNA recognition. J. Biol. Chem.276, 17484–17496 (2001). ArticleCAS Google Scholar
Ostareck, D.H. et al. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3′ end. Cell89, 597–606 (1997). ArticleCAS Google Scholar
Ostareck, D.H., Ostareck-Lederer, A., Shatsky, I.N. & Hentze, M.W. Lipoxygenase mRNA silencing in erythroid differentiation: the 3′ UTR regulatory complex controls 605 ribosomal subunit joining. Cell104, 281–290 (2001). ArticleCAS Google Scholar
Collier, B., Goobar-Larsson, L., Sokolowski, M. & Schwartz, S. Translational inhibition in vitro of human papillomavirus type 16 L2 mRNA mediated through interaction with heterogeneous ribonucleoprotein K and Poly(rC)-binding proteins 1 and 2. J. Biol. Chem.273, 22648–22656 (1998). ArticleCAS Google Scholar
Blyn, L.B., Towner, J.S., Semler, B.L. & Ehrenfeld, E. Requirement of poly(rC)-binding protein 2 for translation of poliovirus RNA. J. Virol.71, 6243–6246 (1997). CAS Google Scholar
Silvera, D., Gamernik, A.V. & Andino, R. The N-terminal K homology domain of the poly(rC)-binding protein is a major determinant for binding to the poliovirus 5′ untranslated region and acts as an inhibitor of viral translation. J. Biol. Chem.274, 38163–38170 (1999). ArticleCAS Google Scholar
Graff, J., Cha, J., Blyn, L.B. & Ehrenfeld, E. Interaction of poly(rC)-binding protein 2 with the 5? noncoding region of hepatitis A virus RNA and its effects on translation. J. Virol.72, 9668–9675 (1998). CAS Google Scholar
Pabst, T. et al. Dominant-negative mutations of C/EBPα, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nature Genet.27, 263–270 (2001). ArticleCAS Google Scholar
Westendorf, J.J. et al. The t(8;21) fusion product, AML-1-ETO, associates with C/EBPα, inhibits C/EBPα-dependent transcription, and blocks granulocytic differentiation. Mol. Cell. Biol.18, 322–333 (1999). Article Google Scholar
Thomson, A.M., Rogers, J.T., Walker, C.E., Staton, J.M. & Leedman, P.J. Optimized RNA gel-shift and UV crosslinking assays for characterization of cytoplasmic RNA-protein interactions. Biotechniques27, 1032–1039 (1999). Article Google Scholar
Gamarnik, A.V. & Andino, R. Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of poliovirus RNA. RNA3, 882–892 (1997). CAS Google Scholar