Chromosomal silencing and localization are mediated by different domains of Xist RNA (original) (raw)
References
Barr, M.L. & Bertram, E.G. A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis. Nature163, 676–677 (1949). ArticleCASPubMed Google Scholar
Avner, P. & Heard, E. X-chromosome inactivation: counting, choice and initiation. Nature Rev. Genet.2, 59–67 (2001). ArticleCASPubMed Google Scholar
Lyon, M.F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature190, 372–373 (1961). ArticleCASPubMed Google Scholar
Russell, L.B. Genetics of mammalian sex chromosomes. Science, 1795–1803 (1961).
Brown, C.J. & Willard, H.F. Localization of the X inactivation center (XIC) to Xq13. Cytogenet. Cell. Genet.51, 971 (1989). Google Scholar
Brown, C.J. et al. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature349, 38–44 (1991). ArticleCASPubMed Google Scholar
Brockdorff, N. et al. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature351, 329–331 (1991). ArticleCASPubMed Google Scholar
Brown, C.J. et al. The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell71, 527–542 (1992). ArticleCASPubMed Google Scholar
Marahrens, Y., Panning, B., Dausman, J., Strauss, W. & Jaenisch, R. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes. Dev.11, 156–166 (1997). ArticleCASPubMed Google Scholar
Penny, G.D., Kay, G.F., Sheardown, S.A., Rastan, S. & Brockdorff, N. Requirement for Xist in X chromosome inactivation. Nature379, 131–137 (1996). ArticleCASPubMed Google Scholar
Lee, J.T., Strauss, W.M., Dausman, J.A. & Jaenisch, R. A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell86, 83–94 (1996). ArticleCASPubMed Google Scholar
Herzing, L.B., Romer, J.T., Horn, J.M. & Ashworth, A. Xist has properties of the X-chromosome inactivation centre. Nature386, 272–275 (1997). ArticleCASPubMed Google Scholar
Wutz, A. & Jaenisch, R. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol. Cell.5, 695–705 (2000). ArticleCASPubMed Google Scholar
Marahrens, Y., Loring, J. & Jaenisch, R. Role of the Xist gene in X chromosome choosing. Cell92, 657–664 (1998). ArticleCASPubMed Google Scholar
Rasmussen, T.P., Wutz, A., Pehrson, J.R. & Jaenisch, R. Xist expression is sufficient for macroH2A localization. Chromosoma110, 411–420 (2001). ArticleCASPubMed Google Scholar
Brockdorff, N. et al. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell71, 515–526 (1992). ArticleCASPubMed Google Scholar
Tinker, A.V. & Brown, C.J. Induction of XIST expression from the human active X chromosome in mouse/human somatic cell hybrids by DNA demethylation. Nucleic Acids Res.26, 2935–2940 (1998). ArticleCASPubMedPubMed Central Google Scholar
Fukushige, S. & Sauer, B. Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells. Proc. Natl Acad. Sci. USA89, 7905–7909 (1992). ArticleCASPubMedPubMed Central Google Scholar
Baron, U., Freundlieb, S., Gossen, M. & Bujard, H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res.23, 3605–3606 (1995). ArticleCASPubMedPubMed Central Google Scholar
Gossen, M. et al. Transcriptional activation by tetracyclines in mammalian cells. Science268, 1766–1769 (1995). ArticleCASPubMed Google Scholar
Zambrowicz, B.P. et al. Disruption of overlapping transcripts in the ROSA β geo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells. Proc. Natl Acad. Sci. USA94, 3789–3794 (1997). ArticleCASPubMedPubMed Central Google Scholar
Lee, J.T., Davidow, L.S. & Warshawsky, D. Tsix, a gene antisense to Xist at the inactivation centre. Nature Genet.21, 400–404 (1999). ArticleCASPubMed Google Scholar
Costanzi, C. & Pehrson, J.R. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature393, 599–601 (1998). ArticleCASPubMed Google Scholar
Rasmussen, T.P., Mastrangelo, M.A., Eden, A., Pehrson, J.R. & Jaenisch, R. Dynamic relocalization of histone MacroH2A1 from centrosomes to inactive X chromosomes during X inactivation. J. Cell. Biol.150, 1189–1198 (2000). ArticleCASPubMedPubMed Central Google Scholar
Csankovszki, G., Panning, B., Bates, B., Pehrson, J.R. & Jaenisch, R. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nature Genet.22, 323–324 (1999). ArticleCASPubMed Google Scholar
Nesterova, T.B. et al. Characterization of the genomic xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence. Genome Res.11, 833–849 (2001). ArticleCASPubMedPubMed Central Google Scholar
Karn, J. et al. Control of immunodeficiency virus gene expression by the RNA-binding proteins tat and rev. in RNA-Protein Interactions (eds Nagai, K. & Mattaj, I.W.) 192–220 (Oxford University Press, New York, 1994). Google Scholar
Beletskii, A., Hong, Y.-K., Pehrson, J., Egholm, M. & Strauss, W.M. PNA interface mapping demonstrates functional domains in the noncoding RNA Xist. Proc. Natl Acad. Sci. USA98, 9215–9220 (2001). ArticleCASPubMedPubMed Central Google Scholar
Allaman-Pillet, N., Djemai, A., Bonny, C. & Schorderet, D.F. The 5′ repeat elements of the mouse Xist gene inhibit the transcription of X-linked genes. Gene. Expr.9, 93–101 (2000). ArticleCASPubMed Google Scholar
Kelley, R.L. & Kuroda, M.I. Noncoding RNA genes in dosage compensation and imprinting. Cell103, 9–12 (2000). ArticleCASPubMed Google Scholar
Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet.21, 70–71 (1999). ArticleCASPubMed Google Scholar
Baron, U., Gossen, M. & Bujard, H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res.25, 2723–2729 (1997). ArticleCASPubMedPubMed Central Google Scholar
Wutz, A. et al. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development128, 1881–1887 (2001). CASPubMed Google Scholar