Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins (original) (raw)

• Cohen, M.S. Molecular events in the activation of human neutrophils for microbial killing. Clin. Infect. Dis. 18 Suppl 2, S170–S179 (1994).
  Article CAS PubMed Google Scholar
• Stevens, T., Garcia, J.G., Shasby, D.M., Bhattacharya, J. & Malik, A.B. Mechanisms regulating endothelial cell barrier function. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L419–L422 (2000).
  Article CAS PubMed Google Scholar
• Liu, Y. et al. Regulation of leukocyte transmigration: cell surface interactions and signaling events. J. Immunol. 172, 7–13 (2004).
  Article CAS PubMed Google Scholar
• Simpson, S.Q. & Casey, L.C. Role of tumor necrosis factor in sepsis and acute lung injury. Crit. Care Clin. 5, 27–47 (1989).
  Article CAS PubMed Google Scholar
• Crockett-Torabi, E. & Ward, P.A. The role of leukocytes in tissue injury. Eur. J. Anaesthesiol. 13, 235–246 (1996).
  Article CAS PubMed Google Scholar
• Adelstein, R.S. Regulation of contractile proteins by phosphorylation. J. Clin. Invest. 72, 1863–1866 (1983).
  Article CAS PubMed PubMed Central Google Scholar
• Kamm, K.E. & Stull, J.T. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu. Rev. Pharmacol. Toxicol. 25, 593–620 (1985).
  Article CAS PubMed Google Scholar
• Kamm, K.E. & Stull, J.T. Dedicated myosin light chain kinases with diverse cellular functions. J. Biol. Chem. 276, 4527–4530 (2001).
  Article CAS PubMed Google Scholar
• Kudryashov, D.S. et al. Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton. FEBS Lett. 463, 67–71 (1999).
  Article CAS PubMed Google Scholar
• Wainwright, M.S. et al. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc. Natl. Acad. Sci. USA 100, 6233–6238 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Garcia, J.G., Davis, H.W. & Patterson, C.E. Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J. Cell. Physiol. 163, 510–522 (1995).
  Article CAS PubMed Google Scholar
• Yuan, S.Y. et al. Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage. Circ. Res. 90, 1214–1221 (2002).
  Article CAS PubMed Google Scholar
• Hynes, R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673–687 (2002).
  Article CAS PubMed Google Scholar
• Lowell, C.A. & Berton, G. Integrin signal transduction in myeloid leukocytes. J. Leukoc. Biol. 65, 313–320 (1999).
  Article CAS PubMed Google Scholar
• Ginsberg, M.H., Partridge, A. & Shattil, S.J. Integrin regulation. Curr. Opin. Cell Biol. 17, 509–516 (2005).
  Article CAS PubMed Google Scholar
• Luo, B.H., Carman, C.V. & Springer, T.A. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25, 619–647 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Ley, K. Integration of inflammatory signals by rolling neutrophils. Immunol. Rev. 186, 8–18 (2002).
  Article CAS PubMed Google Scholar
• Calderwood, D.A., Shattil, S.J. & Ginsberg, M.H. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J. Biol. Chem. 275, 22607–22610 (2000).
  Article CAS PubMed Google Scholar
• van Kooyk, Y. & Figdor, C.G. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr. Opin. Cell Biol. 12, 542–547 (2000).
  Article CAS PubMed Google Scholar
• Totani, L. et al. Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem. J. 396, 89–98 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Shamri, R. et al. Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat. Immunol. 6, 497–506 (2005).
  Article CAS PubMed Google Scholar
• Advani, A., Marshall, S.M. & Thomas, T.H. Impaired neutrophil actin assembly causes persistent CD11b expression and reduced primary granule exocytosis in type II diabetes. Diabetologia 45, 719–727 (2002).
  Article CAS PubMed Google Scholar
• Anderson, S.I., Hotchin, N.A. & Nash, G.B. Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils. J. Cell Sci. 113, 2737–2745 (2000).
  CAS PubMed Google Scholar
• DeMali, K.A., Wennerberg, K. & Burridge, K. Integrin signaling to the actin cytoskeleton. Curr. Opin. Cell Biol. 15, 572–582 (2003).
  Article CAS PubMed Google Scholar
• Smith, A., Bracke, M., Leitinger, B., Porter, J.C. & Hogg, N. LFA-1-induced T cell migration on ICAM-1 involves regulation of MYLK-mediated attachment and ROCK-dependent detachment. J. Cell Sci. 116, 3123–3133 (2003).
  Article CAS PubMed Google Scholar
• Webb, D.J. et al. FAK-Src signalling through paxillin, ERK and MYLK regulates adhesion disassembly. Nat. Cell Biol. 6, 154–161 (2004).
  Article CAS PubMed Google Scholar
• Kudryashov, D.S. et al. Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Exp. Cell Res. 298, 407–417 (2004).
  Article CAS PubMed Google Scholar
• Vilitkevich, E.L., Kudriashev, D.S., Stepanova, O.V. & Shirinskii, V.P. A new actin-binding area of the myosin light chains' high-molecular kinase. Ross. Fiziol. Zh. Im. I. M. Sechenova 90, 577–585 (2004).
  CAS PubMed Google Scholar
• Dudek, S.M., Birukov, K.G., Zhan, X. & Garcia, J.G. Novel interaction of cortactin with endothelial cell myosin light chain kinase. Biochem. Biophys. Res. Commun. 298, 511–519 (2002).
  Article CAS PubMed Google Scholar
• Smith, L. et al. Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo. J. Biol. Chem. 277, 35597–35604 (2002).
  Article CAS PubMed Google Scholar
• Gao, X. et al. Differential role of CD18 integrins in mediating lung neutrophil sequestration and increased microvascular permeability induced by Escherichia coli in mice. J. Immunol. 167, 2895–2901 (2001).
  Article CAS PubMed Google Scholar
• Xu, J. et al. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114, 201–214 (2003).
  Article CAS PubMed Google Scholar
• Straight, A.F. et al. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science 299, 1743–1747 (2003).
  Article CAS PubMed Google Scholar
• Sutton, T.A., Mang, H.E. & Atkinson, S.J. Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion. Am. J. Physiol. Renal Physiol. 281, F810–F818 (2001).
  Article CAS PubMed Google Scholar
• Ueda, K., Murata-Hori, M., Tatsuka, M. & Hosoya, H. Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells. Oncogene 21, 5852–5860 (2002).
  Article CAS PubMed Google Scholar
• Xu, J., Wang, F., Van Keymeulen, A., Rentel, M. & Bourne, H.R. Neutrophil microtubules suppress polarity and enhance directional migration. Proc. Natl. Acad. Sci. USA 102, 6884–6889 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Birukov, K.G. et al. Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60Src. J. Biol. Chem. 276, 8567–8573 (2001).
  Article CAS PubMed Google Scholar
• Ren, X.R. et al. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. J. Cell Biol. 152, 971–984 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Murata-Hori, M., Suizu, F., Iwasaki, T., Kikuchi, A. & Hosoya, H. ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells. FEBS Lett. 451, 81–84 (1999).
  Article CAS PubMed Google Scholar
• Berton, G., Mocsai, A. & Lowell, C.A. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 26, 208–214 (2005).
  Article CAS PubMed Google Scholar
• Lowell, C.A., Fumagalli, L. & Berton, G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133, 895–910 (1996).
  Article CAS PubMed Google Scholar
• Thakur, M.L. et al. Indium-111-labeled cellular blood components: mechanism of labeling and intracellular location in human neutrophils. J. Nucl. Med. 18, 1022–1026 (1977).
  CAS PubMed Google Scholar
• Mansfield, P.J., Hinkovska-Galcheva, V., Carey, S.S., Shayman, J.A. & Boxer, L.A. Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. Blood 99, 1434–1441 (2002).
  Article CAS PubMed Google Scholar
• Betsuyaku, T. et al. A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation. J. Clin. Invest. 103, 825–832 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Gao, X.P. et al. Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury. Physiol. Genomics 21, 230–242 (2005).
  Article CAS PubMed Google Scholar
• Vogel, S.M. et al. Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol. Genomics 4, 137–145 (2000).
  Article CAS PubMed Google Scholar