Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration (original) (raw)

• Förster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23–33 (1999).
  Article Google Scholar
• Ohl, L. et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21, 279–288 (2004).
  Article CAS Google Scholar
• Ouwehand, K. et al. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur. J. Immunol. 38, 3050–3059 (2008).
  Article CAS Google Scholar
• Saeki, H., Moore, A.M., Brown, M.J. & Hwang, S.T. Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162, 2472–2475 (1999).
  CAS PubMed Google Scholar
• Baluk, P. et al. Functionally specialized junctions between endothelial cells of lymphatic vessels. J. Exp. Med. 204, 2349–2362 (2007).
  Article CAS Google Scholar
• Lämmermann, T. et al. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453, 51–55 (2008).
  Article Google Scholar
• Pflicke, H. & Sixt, M. Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J. Exp. Med. 206, 2925–2935 (2009).
  Article CAS Google Scholar
• Bromley, S.K., Thomas, S.Y. & Luster, A.D. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol. 6, 895–901 (2005).
  Article CAS Google Scholar
• Debes, G.F. et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat. Immunol. 6, 889–894 (2005).
  Article CAS Google Scholar
• Luther, S.A., Tang, H.L., Hyman, P.L., Farr, A.G. & Cyster, J.G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97, 12694–12699 (2000).
  Article CAS Google Scholar
• Link, A. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat. Immunol. 8, 1255–1265 (2007).
  Article CAS Google Scholar
• Tomei, A.A., Siegert, S., Britschgi, M.R., Luther, S.A. & Swartz, M.A. Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment. J. Immunol. 183, 4273–4283 (2009).
  Article CAS Google Scholar
• Stein, J.V. et al. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J. Exp. Med. 191, 61–76 (2000).
  Article CAS Google Scholar
• Worbs, T., Mempel, T.R., Bolter, J., von Andrian, U.H. & Forster, R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med. 204, 489–495 (2007).
  Article CAS Google Scholar
• Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451–460 (1999).
  Article CAS Google Scholar
• Harrell, M.I., Iritani, B.M. & Ruddell, A. Lymph node mapping in the mouse. J. Immunol. Methods 332, 170–174 (2008).
  Article CAS Google Scholar
• Bakocević, N., Worbs, T., Davalos-Misslitz, A. & Forster, R. T cell-dendritic cell interaction dynamics during the induction of respiratory tolerance and immunity. J. Immunol. 184, 1317–1327 (2010).
  Article Google Scholar
• Yanagawa, Y. & Onoe, K. CCL19 induces rapid dendritic extension of murine dendritic cells. Blood 100, 1948–1956 (2002).
  Article CAS Google Scholar
• MartIn-Fontecha, A. et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J. Exp. Med. 198, 615–621 (2003).
  Article CAS Google Scholar
• Byrne, S.N., Halliday, G.M., Johnston, L.J. & King, N.J. Interleukin-1β but not tumor necrosis factor is involved in West Nile virus-induced Langerhans cell migration from the skin in C57BL/6 mice. J. Invest. Dermatol. 117, 702–709 (2001).
  Article CAS Google Scholar
• Cahill, R., Hay, J.B., Frost, H. & Trnka, Z. Changes in lymphocyte circulation after administration of antigen. Haematologia (Budap.) 8, 321–334 (1974).
  CAS Google Scholar
• Hintzen, G. et al. Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J. Immunol. 177, 7346–7354 (2006).
  Article CAS Google Scholar
• Schumann, K. et al. Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity 32, 703–713 (2010).
  Article CAS Google Scholar
• Bajénoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989–1001 (2006).
  Article Google Scholar
• Mempel, T.R., Junt, T. & von Andrian, U.H. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity 25, 867–869 (2006).
  Article CAS Google Scholar
• Pham, T.H., Okada, T., Matloubian, M., Lo, C.G. & Cyster, J.G. S1P1 receptor signaling overrides retention mediated by Gαi–coupled receptors to promote T cell egress. Immunity 28, 122–133 (2008).
  Article CAS Google Scholar
• Grigorova, I.L. et al. Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat. Immunol. 10, 58–65 (2009).
  Article CAS Google Scholar
• Grigorova, I.L., Panteleev, M. & Cyster, J.G. Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc. Natl. Acad. Sci. USA 107, 20447–20452 (2010).
  Article CAS Google Scholar
• Schwab, S.R. & Cyster, J.G. Finding a way out: lymphocyte egress from lymphoid organs. Nat. Immunol. 8, 1295–1301 (2007).
  Article CAS Google Scholar
• Spiegel, S. & Milstien, S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 11, 403–415 (2011).
  Article CAS Google Scholar
• Lo, C.G., Xu, Y., Proia, R.L. & Cyster, J.G. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201, 291–301 (2005).
  Article CAS Google Scholar
• Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355–360 (2004).
  Article CAS Google Scholar
• Kissenpfennig, A. et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22, 643–654 (2005).
  Article CAS Google Scholar
• Lindquist, R.L. et al. Visualizing dendritic cell networks in vivo. Nat. Immunol. 5, 1243–1250 (2004).
  Article CAS Google Scholar
• Nikolić-Zugić, J. & Bevan, M.J. Role of self-peptides in positively selecting the T-cell repertoire. Nature 344, 65–67 (1990).
  Article Google Scholar
• Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. & Nishimune, Y. ′Green mice′ as a source of ubiquitous green cells. FEBS Lett. 407, 313–319 (1997).
  Article CAS Google Scholar
• Worbs, T. et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J. Exp. Med. 203, 519–527 (2006).
  Article CAS Google Scholar
• Halle, S. et al. Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. J. Exp. Med. 206, 2593–2601 (2009).
  Article CAS Google Scholar