The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB (original) (raw)

• Davis, B.K., Wen, H. & Ting, J.P.-Y. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu. Rev. Immunol. 29, 707–735 (2010).
  Article Google Scholar
• Martinon, F., Gaide, O., Pétrilli, V., Mayor, A. & Tschopp, J. NALP inflammasomes: a central role in innate immunity. Semin. Immunopathol. 29, 213–229 (2007).
  Article CAS Google Scholar
• Lamkanfi, M. & Dixit, V.M. Modulation of inflammasome pathways by bacterial and viral pathogens. J. Immunol. 187, 597–602 (2011).
  Article CAS Google Scholar
• Davis, B.K. et al. Cutting Edge: NLRC5-dependent activation of the inflammasome. J. Immunol. 186, 1333–1337 (2011).
  Article CAS Google Scholar
• Bruey, J.M. et al. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-κB and caspase-1 activation in macrophages. J. Biol. Chem. 279, 51897–51907 (2004).
  Article CAS Google Scholar
• Khare, S. et al. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity 36, 464–476 (2012).
  Article CAS Google Scholar
• Bauernfeind, F.G. et al. Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787–791 (2009).
  Article CAS Google Scholar
• Chamaillard, M. et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 4, 702–707 (2003).
  Article CAS Google Scholar
• Girardin, S.E. Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science 300, 1584–1587 (2003).
  Article CAS Google Scholar
• Girardin, S.E. et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J. Biol. Chem. 278, 41702–41708 (2003).
  Article CAS Google Scholar
• Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278, 5509–5512 (2003).
  Article CAS Google Scholar
• Bertrand, M.J.M. et al. Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity 30, 789–801 (2009).
  Article CAS Google Scholar
• Strober, W., Murray, P.J., Kitani, A. & Watanabe, T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 6, 9–20 (2005).
  Article Google Scholar
• Abbott, D.W. et al. Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol. Cell. Biol. 27, 6012–6025 (2007).
  Article CAS Google Scholar
• Tao, M. et al. ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr. Biol. 19, 1255–1263 (2009).
  Article CAS Google Scholar
• Ting, J.P.Y., Duncan, J.A. & Lei, Y. How the noninflammasome NLRs function in the innate immune system. Science 327, 286–290 (2010).
  Article CAS Google Scholar
• Allen, I.C. et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity 10.1016/j.immuni.2012.03.012 (2012).
• Zaki, M.H. et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20, 649–660 (2011).
  Article CAS Google Scholar
• Moore, C.B. et al. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451, 573–577 (2008).
  Article CAS Google Scholar
• Allen, I.C. et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity 34, 854–865 (2011).
  Article CAS Google Scholar
• Xia, X. et al. NLRX1 negatively regulates TLR-Induced NF-κB signaling by targeting TRAF6 and IKK. Immunity 34, 843–853 (2011).
  Article CAS Google Scholar
• Benko, S., Magalhaes, J.G., Philpott, D.J. & Girardin, S.E. NLRC5 limits the activation of inflammatory pathways. J. Immunol. 185, 1681–1691 (2010).
  Article CAS Google Scholar
• Cui, J. et al. NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways. Cell 141, 483–496 (2010).
  Article CAS Google Scholar
• Kumar, H. et al. NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections. J. Immunol. 186, 994–1000 (2011).
  Article CAS Google Scholar
• Staehli, F. et al. NLRC5 deficiency selectively impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells. J. Immunol. 188, 3820–3828 (2012).
  Article CAS Google Scholar
• Tong, Y. et al. Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice. Cell Res. 22, 822–835 (2012).
  Article CAS Google Scholar
• Rothe, M., Sarma, V., Dixit, V.M. & Goeddel, D.V. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269, 1424–1427 (1995).
  Article CAS Google Scholar
• Nakano, H. et al. TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor. J. Biol. Chem. 271, 14661–14664 (1996).
  Article CAS Google Scholar
• Hasegawa, M. et al. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation. EMBO J. 27, 373–383 (2008).
  Article CAS Google Scholar
• Devin, A. et al. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12, 419–429 (2000).
  Article CAS Google Scholar
• Conze, D.B., Wu, C.-J., Thomas, J.A., Landstrom, A. & Ashwell, J.D. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and Toll-like receptor-mediated NF-κB activation. Mol. Cell. Biol. 28, 3538–3547 (2008).
  Article CAS Google Scholar
• Lamothe, B. et al. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation. J. Biol. Chem. 282, 4102–4112 (2006).
  Article Google Scholar
• Sebban, H., Yamaoka, S. & Courtois, G. Posttranslational modifications of NEMO and its partners in NF-κB signaling. Trends Cell Biol. 16, 569–577 (2006).
  Article CAS Google Scholar
• Deng, L. et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351–361 (2000).
  Article CAS Google Scholar
• Kishimoto, K., Matsumoto, K. & Ninomiya-Tsuji, J. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem. 275, 7359–7364 (2000).
  Article CAS Google Scholar
• Bishop, G.A. The multifaceted roles of TRAFs in the regulation of B-cell function. Nat. Rev. Immunol. 4, 775–786 (2004).
  Article CAS Google Scholar
• Lamothe, B. et al. The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J. Biol. Chem. 283, 24871–24880 (2008).
  Article CAS Google Scholar
• Skaug, B., Jiang, X. & Chen, Z.J. The role of ubiquitin in NF-κB regulatory pathways. Annu. Rev. Biochem. 78, 769–796 (2009).
  Article CAS Google Scholar
• Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424, 793–796 (2003).
  Article CAS Google Scholar
• Heyninck, K. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-κB activation at the level of TRAF6. FEBS Lett. 442, 147–150 (1999).
  Article CAS Google Scholar
• Boone, D.L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol. 5, 1052–1060 (2004).
  Article CAS Google Scholar
• Brummelkamp, T.R., Nijman, S.M.B., Dirac, A.M.G. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797–801 (2003).
  Article CAS Google Scholar
• Kovalenko, A. et al. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 424, 801–805 (2003).
  Article CAS Google Scholar
• Conti, B.J. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J. Biol. Chem. 280, 18375–18385 (2004).
  Article Google Scholar
• Horie, R. et al. A novel domain in the CD30 cytoplasmic tail mediates NFκB activation. Int. Immunol. 10, 203–210 (1998).
  Article CAS Google Scholar
• Marinis, J.M., Homer, C.R., McDonald, C. & Abbott, D.W. A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses. J. Biol. Chem. 286, 1938–1950 (2010).
  Article Google Scholar
• Ye, H., Park, Y.C., Kreishman, M., Kieff, E. & Wu, H. The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol. Cell. 4, 321–330 (1999).
  Article CAS Google Scholar
• Coornaert, B., Carpentier, I. & Beyaert, R. A20: central gatekeeper in inflammation and immunity. J. Biol. Chem. 284, 8217–8221 (2008).
  Article Google Scholar
• Sun, S.-C. Deubiquitylation and regulation of the immune response. Nat. Rev. Immunol. 8, 501–511 (2008).
  Article CAS Google Scholar
• Taxman, D.J. et al. Criteria for effective design, construction, and gene knockdown by shRNA vectors. BMC Biotechnol. 6, 7 (2006).
  Article Google Scholar