Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice (original) (raw)

• Takeuchi O, Akira S . Pattern recognition receptors and inflammation. Cell 2010; 140:805–820.
  Article CAS Google Scholar
• Schroder K, Tschopp J . The inflammasomes. Cell 2010; 140:821–832.
  Article CAS Google Scholar
• Kawai T, Akira S . The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010; 11:373–384.
  Article CAS Google Scholar
• Wilkins C, Gale M Jr . Recognition of viruses by cytoplasmic sensors. Curr Opin Immunol 2010; 22:41–47.
  Article CAS Google Scholar
• Chiu YH, Macmillan JB, Chen ZJ . RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009; 138:576–591.
  Article CAS Google Scholar
• Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V . RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009; 10:1065–1072.
  Article CAS Google Scholar
• Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ . The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol 2011; 12:959–965.
  Article CAS Google Scholar
• Unterholzner L, Keating SE, Baran M, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010; 11:997–1004.
  Article CAS Google Scholar
• Inohara N, Nunez G . NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 2003; 3:371–382.
  Article CAS Google Scholar
• Kufer TA, Sansonetti PJ . NLR functions beyond pathogen recognition. Nat Immunol 2011; 12:121–128.
  Article CAS Google Scholar
• Moore CB, Bergstralh DT, Duncan JA, et al. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 2008; 451:573–577.
  Article CAS Google Scholar
• Xia X, Cui J, Wang HY, et al. NLRX1 negatively regulates TLR-induced NF-kappaB signaling by targeting TRAF6 and IKK. Immunity 2011; 34:843–853.
  Article CAS Google Scholar
• Allen IC, Moore CB, Schneider M, et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-kappa B signaling pathways. Immunity 2011; 34:854–865.
  Article CAS Google Scholar
• Tattoli I, Carneiro LA, Jehanno M, et al. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappa B and JNK pathways by inducing reactive oxygen species production. EMBO Rep 2008; 9:293–300.
  Article CAS Google Scholar
• Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F . NLRP4 negatively regulates autophagic processes through an association with Beclin1. J Immunol 2011; 186:1646–1655.
  Article CAS Google Scholar
• Fiorentino L, Stehlik C, Oliveira V, Ariza ME, Godzik A, Reed JC . A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1 beta. J Biol Chem 2002; 277:35333–35340.
  Article CAS Google Scholar
• Cui J, Zhu L, Xia XJ, et al. NLRC5 negatively regulates the NF-kappa B and type I interferon signaling pathways. Cell 2010; 141:483–496.
  Article CAS Google Scholar
• Benko S, Magalhaes JG, Philpott DJ, Girardin SE . NLRC5 limits the activation of inflammatory pathways. J Immunol 2010; 185:1681–1691.
  Article CAS Google Scholar
• Kuenzel S, Till A, Winkler M, et al. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J Immunol 2010; 184:1990–2000.
  Article CAS Google Scholar
• Neerincx A, Lautz K, Menning M, et al. A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem 2010; 285:26223–26232.
  Article CAS Google Scholar
• Davis BK, Roberts RA, Huang MT, et al. Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol 2011; 186:1333–1337.
  Article CAS Google Scholar
• Meissner TB, Li A, Biswas A, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci USA 2010; 107:13794–13799.
  Article CAS Google Scholar
• Kumar H, Pandey S, Zou J, et al. NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections. J Immunol 2011; 186:994–1000.
  Article CAS Google Scholar
• O'Shea JJ, Gadina M, Schreiber RD . Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002; 109 Suppl:S121–S131.
  Article Google Scholar
• Shuai K, Liu B . Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003; 3:900–911.
  Article CAS Google Scholar
• LeibundGut-Landmann S, Waldburger JM, Krawczyk M, et al. Mini-review: specificity and expression of CIITA, the master regulator of MHC class II genes. Eur J Immunol 2004; 34:1513–1525.
  Article CAS Google Scholar
• Wright KL, Ting JP . Epigenetic regulation of MHC-II and CIITA genes. Trends Immunol 2006; 27:405–412.
  Article CAS Google Scholar
• Honda K, Taniguchi T . IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 2006; 6:644–658.
  Article CAS Google Scholar
• Ajibade AA, Wang Q, Cui J, et al. TAK1 negatively regulates NF-kappaB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils. Immunity 2012; 36:43–54.
  Article Google Scholar
• Kawagoe T, Takeuchi O, Takabatake Y, et al. TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol 2009; 10:965–972.
  Article CAS Google Scholar
• Han J, Ulevitch RJ . Limiting inflammatory responses during activation of innate immunity. Nat Immunol 2005; 6:1198–1205.
  Article CAS Google Scholar
• Kanzler H, Barrat FJ, Hessel EM, Coffman RL . Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13:552–559.
  Article CAS Google Scholar
• Li HY, Liu H, Wang CH, et al. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol 2008; 9:533–541.
  Article CAS Google Scholar
• Rebsamen M, Vazquez J, Tardivel A, Guarda G, Curran J, Tschopp J . NLRX1/NOD5 deficiency does not affect MAVS signalling. Cell Death Differ 2011; 18:1387.
  Article CAS Google Scholar