Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment (original) (raw)

• Till, J.E. & McCulloch, E.A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 175, 145–149 (1961).
  Article CAS Google Scholar
• Becker, A.J., McCulloch, E.A. & Till, J.E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197, 452–454 (1963).
  Article CAS PubMed Google Scholar
• Spangrude, G.J., Heimfeld, S. & Weissman, I.L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58–62 (1988).
  Article CAS PubMed Google Scholar
• Seita, J. & Weissman, I.L. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip. Rev. Syst. Biol. Med. 2, 640–653 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Zeng, H., Yucel, R., Kosan, C., Klein-Hitpass, L. & Moroy, T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 23, 4116–4125 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Perry, J.M. & Li, L. Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis. Genes Dev. 22, 1107–1109 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Antonchuk, J., Sauvageau, G. & Humphries, R.K. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109, 39–45 (2002).
  Article CAS PubMed Google Scholar
• Chang, K.C. et al. Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal. Dev. Cell 19, 778–785 (2010).
  Article CAS PubMed Google Scholar
• Scheel, C. et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145, 926–940 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Bröske, A.M. et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat. Genet. 41, 1207–1215 (2009).
  Article PubMed CAS Google Scholar
• Sun, Y., Hu, J., Zhou, L., Pollard, S.M. & Smith, A. Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells. J. Cell Sci. 124, 1867–1877 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Alvarez, J.D. et al. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev. 14, 521–535 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Yasui, D., Miyano, M., Cai, S., Varga-Weisz, P. & Kohwi-Shigematsu, T. SATB1 targets chromatin remodelling to regulate genes over long distances. Nature 419, 641–645 (2002).
  Article CAS PubMed Google Scholar
• Beyer, M. et al. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat. Immunol. 12, 898–907 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Steidl, U. et al. A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. J. Clin. Invest. 117, 2611–2620 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Savarese, F. et al. Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev. 23, 2625–2638 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Han, H.J., Russo, J., Kohwi, Y. & Kohwi-Shigematsu, T. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 452, 187–193 (2008).
  Article CAS PubMed Google Scholar
• Lakshminarayana Reddy, C.N., Vyjayanti, V.N., Notani, D., Galande, S. & Kotamraju, S. Down-regulation of the global regulator SATB1 by statins in COLO205 colon cancer cells. Mol. Med. Rep. 3, 857–861 (2010).
  CAS PubMed Google Scholar
• Selinger, C.I. et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. J. Thorac. Oncol. 6, 1179–1189 (2011).
  Article PubMed Google Scholar
• Cai, S., Han, H.J. & Kohwi-Shigematsu, T. Tissue-specific nuclear architecture and gene expression regulated by SATB1. Nat. Genet. 34, 42–51 (2003).
  Article CAS PubMed Google Scholar
• Cai, S., Lee, C.C. & Kohwi-Shigematsu, T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat. Genet. 38, 1278–1288 (2006).
  Article CAS PubMed Google Scholar
• Challen, G.A., Boles, N., Lin, K.K. & Goodell, M.A. Mouse hematopoietic stem cell identification and analysis. Cytometry A 75, 14–24 (2009).
  Article PubMed PubMed Central Google Scholar
• Matsumoto, A. et al. P57 is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells. Cell Stem Cell 9, 262–271 (2011).
  Article CAS PubMed Google Scholar
• Passegué, E., Wagers, A.J., Giuriato, S., Anderson, W.C. & Weissman, I.L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J. Exp. Med. 202, 1599–1611 (2005).
  Article PubMed PubMed Central CAS Google Scholar
• Takizawa, H., Regoes, R.R., Boddupalli, C.S., Bonhoeffer, S. & Manz, M.G. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J. Exp. Med. 208, 273–284 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118–1129 (2008).
  Article CAS PubMed Google Scholar
• Morita, Y., Ema, H. & Nakauchi, H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J. Exp. Med. 207, 1173–1182 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Kharas, M.G. et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat. Med. 16, 903–908 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Wu, M. et al. Imaging hematopoietic precursor division in real time. Cell Stem Cell 1, 541–554 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Rhyu, M.S., Jan, L.Y. & Jan, Y.N. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76, 477–491 (1994).
  Article CAS PubMed Google Scholar
• Spana, E.P. & Doe, C.Q. Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17, 21–26 (1996).
  Article CAS PubMed Google Scholar
• Rebeiz, M., Miller, S.W. & Posakony, J.W. Notch regulates numb: integration of conditional and autonomous cell fate specification. Development 138, 215–225 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545–15550 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Zeller, K.I. et al. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc. Natl. Acad. Sci. USA 103, 17834–17839 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Huang, M.J., Cheng, Y.C., Liu, C.R., Lin, S. & Liu, H.E. A small-molecule c-Myc inhibitor, 10058–F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp. Hematol. 34, 1480–1489 (2006).
  Article CAS PubMed Google Scholar
• Delmore, J.E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904–917 (2011).
  CAS PubMed PubMed Central Google Scholar
• Pinto do, O.P., Kolterud, A. & Carlsson, L. Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors. EMBO J. 17, 5744–5756 (1998).
  Article CAS Google Scholar
• Mahmoudi, T. et al. The kinase TNIK is an essential activator of Wnt target genes. EMBO J. 28, 3329–3340 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Fazzio, T.G., Huff, J.T. & Panning, B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 134, 162–174 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Miyazaki, M. et al. The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nat. Immunol. 12, 992–1001 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Wontakal, S.N. et al. A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1. PLoS Genet. 7, e1001392.1–15 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Nerlov, C. & Graf, T.P.U. 1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev. 12, 2403–2412 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Orford, K.W. & Scadden, D.T. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat. Rev. Genet. 9, 115–128 (2008).
  Article CAS PubMed Google Scholar
• Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804–1808 (2000).
  Article CAS PubMed Google Scholar
• Massagué, J. G1 cell-cycle control and cancer. Nature 432, 298–306 (2004).
  Article PubMed CAS Google Scholar
• Xi, R. & Xie, T. Stem cell self-renewal controlled by chromatin remodeling factors. Science 310, 1487–1489 (2005).
  Article CAS PubMed Google Scholar
• Reavie, L. et al. Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat. Immunol. 11, 207–215 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Santaguida, M. et al. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell 15, 341–352 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Klinakis, A. et al. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473, 230–233 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Li, Q.Q. et al. Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells. Cancer Sci. 101, 80–86 (2010).
  Article CAS PubMed Google Scholar
• Kossenkov, A.V. & Ochs, M.F. Matrix factorization for recovery of biological processes from microarray data. Methods Enzymol. 467, 59–77 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Maggio-Price, L., Wolf, N.S., Priestley, G.V., Pietrzyk, M.E. & Bernstein, S.E. Evaluation of stem cell reserve using serial bone marrow transplantation and competitive repopulation in a murine model of chronic hemolytic anemia. Exp. Hematol. 16, 653–659 (1988).
  CAS PubMed Google Scholar
• Szilvassy, S.J., Nicolini, F.E., Eaves, C.J. & Miller, C.L. Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts. Methods Mol. Med. 63, 167–187 (2002).
  PubMed Google Scholar
• Lyons, A.B. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243, 147–154 (2000).
  Article CAS PubMed Google Scholar
• Akalin, A. et al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet. 8, e1002781 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Krueger, F. & Andrews, S.R. Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Bioinformatics 27, 1571–1572 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Akalin, A. et al. methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol. 13, R87 (2012).
  Article PubMed PubMed Central Google Scholar
• Quinlan, A.R. & Hall, I.M. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841–842 (2010).
  Article CAS PubMed PubMed Central Google Scholar