Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection (original) (raw)

• Crispe, I.N. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3, 51–62 (2003).
  Article CAS Google Scholar
• Thomson, A.W. & Knolle, P.A. Antigen-presenting cell function in the tolerogenic liver environment. Nat. Rev. Immunol. 10, 753–766 (2010).
  Article CAS Google Scholar
• Crispe, I.N. The liver as a lymphoid organ. Annu. Rev. Immunol. 27, 147–163 (2009).
  Article CAS Google Scholar
• Protzer, U., Maini, M.K. & Knolle, P.A. Living in the liver: hepatic infections. Nat. Rev. Immunol. 12, 201–213 (2012).
  Article CAS Google Scholar
• Isogawa, M., Furuichi, Y. & Chisari, F.V. Oscillating CD8+ T cell effector functions after antigen recognition in the liver. Immunity 23, 53–63 (2005).
  Article CAS Google Scholar
• Das, A. et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J. Exp. Med. 205, 2111–2124 (2008).
  Article CAS Google Scholar
• Lopes, A.R. et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J. Clin. Invest. 118, 1835–1845 (2008).
  Article CAS Google Scholar
• Chakravarty, S. et al. CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat. Med. 13, 1035–1041 (2007).
  Article CAS Google Scholar
• Cockburn, I.A. et al. Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog. 6, e1000877 (2010).
  Article Google Scholar
• Wong, P. & Pamer, E.G. Feedback regulation of pathogen-specific T cell priming. Immunity 18, 499–511 (2003).
  Article CAS Google Scholar
• Kang, S.S. et al. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. J. Exp. Med. 208, 747–759 (2011).
  Article CAS Google Scholar
• Neyt, K., Perros, F., GeurtsvanKessel, C.H., Hammad, H. & Lambrecht, B.N. Tertiary lymphoid organs in infection and autoimmunity. Trends Immunol. 33, 297–305 (2012).
  Article CAS Google Scholar
• Moyron-Quiroz, J.E. et al. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat. Med. 10, 927–934 (2004).
  Article CAS Google Scholar
• Rangel-Moreno, J. et al. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat. Immunol. 12, 639–646 (2011).
  Article CAS Google Scholar
• Egen, J.G. et al. Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity 28, 271–284 (2008).
  Article CAS Google Scholar
• Egen, J.G. et al. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity 34, 807–819 (2011).
  Article CAS Google Scholar
• Curtsinger, J.M., Johnson, C.M. & Mescher, M.F. CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine. J. Immunol. 171, 5165–5171 (2003).
  Article CAS Google Scholar
• Lee, S.W., Park, Y., Yoo, J.K., Choi, S.Y. & Sung, Y.C. Inhibition of TCR-induced CD8 T cell death by IL-12: regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12. J. Immunol. 170, 2456–2460 (2003).
  Article CAS Google Scholar
• Macgregor, J.N. et al. Ex vivo culture with interleukin (IL)-12 improves CD8+ T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-γ but requires perforin. Cancer Res. 66, 4913–4921 (2006).
  Article CAS Google Scholar
• Gommerman, J.L. & Browning, J.L. Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat. Rev. Immunol. 3, 642–655 (2003).
  Article CAS Google Scholar
• Drayton, D.L., Liao, S., Mounzer, R.H. & Ruddle, N.H. Lymphoid organ development: from ontogeny to neogenesis. Nat. Immunol. 7, 344–353 (2006).
  Article CAS Google Scholar
• Serbina, N.V., Salazar-Mather, T.P., Biron, C.A., Kuziel, W.A. & Pamer, E.G. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19, 59–70 (2003).
  Article CAS Google Scholar
• Mescher, M.F. et al. Signals required for programming effector and memory development by CD8+ T cells. Immunol. Rev. 211, 81–92 (2006).
  Article CAS Google Scholar
• Croft, M. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu. Rev. Immunol. 28, 57–78 (2010).
  Article CAS Google Scholar
• Stabenow, D. et al. Bioluminescence imaging allows measuring CD8 T cell function in the liver. Hepatology 51, 1430–1437 (2010).
  Article Google Scholar
• Huang, L.R. et al. Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology 142, 1447–1450 (2012).
  Article CAS Google Scholar
• Ramakrishnan, L. Revisiting the role of the granuloma in tuberculosis. Nat. Rev. Immunol. 12, 352–366 (2012).
  Article CAS Google Scholar
• Peters, A. et al. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 35, 986–996 (2011).
  Article CAS Google Scholar
• Hochweller, K. et al. Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc. Natl. Acad. Sci. USA 107, 5931–5936 (2010).
  Article CAS Google Scholar
• Sacher, T. et al. CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes. Eur. J. Immunol. 32, 3628–3637 (2002).
  Article CAS Google Scholar
• Lang, K.S. et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat. Med. 11, 138–145 (2005).
  Article CAS Google Scholar
• Lang, K.S. et al. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. J. Clin. Invest. 116, 2456–2463 (2006).
  Article CAS Google Scholar
• Hohl, T.M. et al. Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe 6, 470–481 (2009).
  Article CAS Google Scholar
• Wohlleber, D. et al. TNF-induced target cell killing by CTL activated through cross-presentation. Cell Reports 2, 478–487 (2012).
  Article CAS Google Scholar
• Haybaeck, J. et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16, 295–308 (2009).
  Article CAS Google Scholar
• Wolf, M.J. et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22, 91–105 (2012).
  Article CAS Google Scholar
• Mildner, A. et al. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 132, 2487–2500 (2009).
  Article Google Scholar
• Jenne, C.N., Wong, C.H., Petri, B. & Kubes, P. The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation. PLoS ONE 6, e25109 (2011).
  Article CAS Google Scholar