IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance (original) (raw)
Basu, R., Hatton, R.D. & Weaver, C.T. The TH17 family: flexibility follows function. Immunol. Rev.252, 89–103 (2013). PubMedPubMed Central Google Scholar
Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity24, 179–189 (2006). CASPubMed Google Scholar
Mangan, P.R. et al. Transforming growth factor-β induces development of the TH17 lineage. Nature441, 231–234 (2006). CASPubMed Google Scholar
Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature441, 235–238 (2006). ArticleCASPubMed Google Scholar
Zhou, L. et al. TGF-beta-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function. Nature453, 236–240 (2008). CASPubMedPubMed Central Google Scholar
Littman, D.R. & Rudensky, A.Y. TH17 and regulatory T cells in mediating and restraining inflammation. Cell140, 845–858 (2010). CASPubMed Google Scholar
Vicente-Suarez, I. et al. Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol.8, 141–151 (2015). CASPubMed Google Scholar
Chen, W. et al. Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med.198, 1875–1886 (2003). CASPubMedPubMed Central Google Scholar
Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science317, 256–260 (2007). CASPubMed Google Scholar
Coombes, J.L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J. Exp. Med.204, 1757–1764 (2007). CASPubMedPubMed Central Google Scholar
Benson, M.J., Pino-Lagos, K., Rosemblatt, M. & Noelle, R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med.204, 1765–1774 (2007). CASPubMedPubMed Central Google Scholar
Sun, C.M. et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med.204, 1775–1785 (2007). CASPubMedPubMed Central Google Scholar
Davidson, T.S., DiPaolo, R.J., Andersson, J. & Shevach, E.M. IL-2 is essential for TGF-β-mediated induction of Foxp3+ T regulatory cells. J. Immunol.178, 4022–4026 (2007). CASPubMed Google Scholar
Laurence, A. et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity26, 371–381 (2007). CASPubMed Google Scholar
Yang, X.P. et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol.12, 247–254 (2011). CASPubMedPubMed Central Google Scholar
Chung, Y. et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity30, 576–587 (2009). CASPubMedPubMed Central Google Scholar
Shaw, M.H., Kamada, N., Kim, Y.G. & Nunez, G. Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine. J. Exp. Med.209, 251–258 (2012). CASPubMedPubMed Central Google Scholar
Atarashi, K. et al. ATP drives lamina propria TH17 cell differentiation. Nature455, 808–812 (2008). CASPubMed Google Scholar
Ivanov, I.I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell139, 485–498 (2009). CASPubMedPubMed Central Google Scholar
Ishigame, H. et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity30, 108–119 (2009). CASPubMed Google Scholar
Basu, R. et al. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity37, 1061–1075 (2012). CASPubMedPubMed Central Google Scholar
Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med.14, 282–289 (2008). CASPubMed Google Scholar
Hirota, K. et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat. Immunol.12, 255–263 (2011). CASPubMedPubMed Central Google Scholar
Harrington, L.E., Janowski, K.M., Oliver, J.R., Zajac, A.J. & Weaver, C.T. Memory CD4 T cells emerge from effector T-cell progenitors. Nature452, 356–360 (2008). CASPubMed Google Scholar
Chen, Z. et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl. Acad. Sci. USA103, 8137–8142 (2006). CASPubMedPubMed Central Google Scholar
Yang, X.-P. et al. Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression. J. Biol. Chem.279, 45279–45289 (2004). CASPubMed Google Scholar
Wen, Z., Zhong, Z. & Darnell, J.E. Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell82, 241–250 (1995). CASPubMed Google Scholar
Laurence, A. et al. STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease. Immunity37, 209–222 (2012). CASPubMedPubMed Central Google Scholar
Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature463, 808–812 (2010). CASPubMedPubMed Central Google Scholar
Murphy, K.M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol.11, 674–680 (2010). CASPubMedPubMed Central Google Scholar
Feng, Y. et al. Control of the inheritance of regulatory T cell Identity by a cis element in the Foxp3 locus. Cell158, 749–763 (2014). CASPubMedPubMed Central Google Scholar
Babon, J.J., Varghese, L.N. & Nicola, N.A. Inhibition of IL-6 family cytokines by SOCS3. Semin. Immunol.26, 13–19 (2014). CASPubMedPubMed Central Google Scholar
Kershaw, N.J. et al. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat. Struct. Mol. Biol.20, 469–476 (2013). CASPubMedPubMed Central Google Scholar
Qin, H. et al. TGF-β promotes Th17 cell development through inhibition of SOCS3. J. Immunol.183, 97–105 (2009). CASPubMed Google Scholar
Ogawa, C. et al. TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2. J. Immunol.192, 475–483 (2014). CASPubMed Google Scholar
Ghoreschi, K. et al. Generation of pathogenic TH17 cells in the absence of TGF-β signalling. Nature467, 967–971 (2010). CASPubMedPubMed Central Google Scholar
Lang, R. et al. SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol.4, 546–550 (2003). CASPubMed Google Scholar
Ivanov, I.I. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell126, 1121–1133 (2006). CASPubMed Google Scholar
Glasmacher, E. et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science338, 975–980 (2012). CASPubMedPubMed Central Google Scholar
Yang, X.O. et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem.282, 9358–9363 (2007). CASPubMed Google Scholar
Miyao, T. et al. Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity36, 262–275 (2012). CASPubMed Google Scholar
Ohkura, N. et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity37, 785–799 (2012). CASPubMed Google Scholar
Wiles, S., Pickard, K.M., Peng, K., MacDonald, T.T. & Frankel, G. In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium. Infect. Immun.74, 5391–5396 (2006). CASPubMedPubMed Central Google Scholar
Yang, X.P. et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol.12, 247–254 (2011). CASPubMedPubMed Central Google Scholar
Bleich, A. et al. Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm. Genome15, 865–871 (2004). PubMed Google Scholar