Not a split decision for human hematopoiesis (original) (raw)

Nature Immunology volume 11, pages 569–570 (2010)Cite this article

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Hematopoietic lineage schemes commonly show two distinct lymphoid and myeloid branches arising from the hematopoietic stem cell early during blood cell development. A new study of human hematopoiesis demonstrates that, similar to findings in mice, this split is not as dichotomous as is often presented.

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Figure 1: Models of hematopoietic differentiation.

References

  1. Doulatov, S. et al. Nat. Immunol. 11, 585–593 (2010).
    Article CAS Google Scholar
  2. Abramson, S., Miller, R.G. & Phillips, R.A. J. Exp. Med. 145, 1567–1579 (1977).
    Article CAS Google Scholar
  3. Keller, G., Paige, C., Gilboa, E. & Wagner, E.F. Nature 318, 149–154 (1985).
    Article CAS Google Scholar
  4. Dick, J.E., Magli, M.C., Huszar, D., Phillips, R.A. & Bernstein, A. Cell 42, 71–79 (1985).
    Article CAS Google Scholar
  5. Fialkow, P.J., Denman, M.D., Jacobson, R.J. & Lowenthal, M.N. J. Clin. Invest. 62, 815–823 (1978).
    Article CAS Google Scholar
  6. Kondo, M. et al. Annu. Rev. Immunol. 21, 759–806 (2003).
    Article CAS Google Scholar
  7. Blom, B. & Spits, H. Annu. Rev. Immunol. 24, 287–320 (2006).
    Article CAS Google Scholar
  8. Katsura, Y. Nat. Rev. Immunol. 2, 127–132 (2002).
    Article CAS Google Scholar
  9. Adolfsson, J. et al. Cell 121, 295–306 (2005).
    Article CAS Google Scholar
  10. Baba, Y., Pelayo, R. & Kincade, P.W. Trends Immunol. 25, 645–649 (2004).
    Article CAS Google Scholar
  11. Payne, K.J. & Crooks, G.M. Immunity 26, 674–677 (2007).
    Article CAS Google Scholar
  12. Shizuru, J.A., Negrin, R.S. & Weissman, I. Annu. Rev. Med. 56, 509–538 (2005).
    Article CAS Google Scholar

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Authors and Affiliations

  1. Kenneth Dorshkind is in the Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.,
    Kenneth Dorshkind

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  1. Kenneth Dorshkind
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Correspondence toKenneth Dorshkind.

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The author declares no competing financial interests.

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Dorshkind, K. Not a split decision for human hematopoiesis.Nat Immunol 11, 569–570 (2010). https://doi.org/10.1038/ni0710-569

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