- Hui, K., Grosveld, F. & Festenstein, H. Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation. Nature 311, 750–752 (1984).
Article CAS Google Scholar
- Restifo, N.P. et al. Identification of human cancers deficient in antigen processing. J. Exp. Med. 177, 265–272 (1993).
Article CAS Google Scholar
- Torre-Amione, G. et al. A highly immunogenic tumor transfected with a murine transforming growth factor type β1 cDNA escapes immune surveillance. Proc. Natl. Acad. Sci. USA 87, 1486–1490 (1990).
Article CAS Google Scholar
- Ye, X., McCarrick, J., Jewett, L. & Knowles, B.B. Timely immunization subverts the development of peripheral nonresponsiveness and suppresses tumor development in simian virus 40 tumor antigen-transgenic mice. Proc. Natl. Acad. Sci. USA 91, 3916–3920 (1994).
Article CAS Google Scholar
- Bogen, B. Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4+ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma. Eur J. Immunol. 26, 2671–2679 (1996).
Article CAS Google Scholar
- Staveley-O'Carroll, K. et al. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proc. Natl. Acad. Sci. USA 95, 1178–1183 (1998).
Article CAS Google Scholar
- Lee, P.P. et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 5, 677–685 (1999).
Article CAS Google Scholar
- Pardoll, D.M. Cancer vaccines. Nat. Med. 4, 525–531 (1998).
Article CAS Google Scholar
- Dranoff, G. & Mulligan, R.C. Gene transfer as cancer therapy. Adv. Immunol. 58, 417–454 (1995).
Article CAS Google Scholar
- Schuler, G. & Steinman, R.M. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J. Exp. Med. 186, 1183–1187 (1997).
Article CAS Google Scholar
- Pardoll, D.M. Spinning molecular immunology into successful immunotherapy. Nat. Rev. Immunol. 2, 227–238 (2002).
Article CAS Google Scholar
- Mayordomo, J.I. et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat. Med. 1, 1297–1302 (1995).
Article CAS Google Scholar
- Nestle, F.O. et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med. 4, 328–332 (1998).
Article CAS Google Scholar
- Paglia, P., Chiodoni, C., Rodolfo, M. & Colombo, M.P. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp. Med. 183, 317–322 (1996).
Article CAS Google Scholar
- Song, W. et al. Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J. Exp. Med. 186, 1247–1256 (1997).
Article CAS Google Scholar
- Specht, J.M. et al. Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. J. Exp. Med. 186, 1213–1221 (1997).
Article CAS Google Scholar
- Dyall, J., Latouche, J.B., Schnell, S. & Sadelain, M. Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes. Blood 97, 114–121 (2001).
Article CAS Google Scholar
- Boczkowski, D., Nair, S.K., Snyder, D. & Gilboa, E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 184, 465–472 (1996).
Article CAS Google Scholar
- Su, Z. et al. Enhanced induction of telomerase-specific CD4+ T cells using dendritic cells transfected with RNA encoding a chimeric gene product. Cancer Res. 62, 5041–5048 (2002).
CAS PubMed Google Scholar
- Smith, G.L., Murphy, B.R. & Moss, B. Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters. Proc. Natl. Acad. Sci. USA 80, 7155–7159 (1983).
Article CAS Google Scholar
- Panicali, D., Davis, S.W., Weinberg, R.L. & Paoletti, E. Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 80, 5364–5368 (1983).
Article CAS Google Scholar
- Carroll, M.W. et al. Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model. Vaccine 15, 387–394 (1997).
Article CAS Google Scholar
- Paoletti, E., Taylor, J., Meignier, B., Meric, C. & Tartaglia, J. Highly attenuated poxvirus vectors: NYVAC, ALVAC and TROVAC. Dev. Biol. Stand. 84, 159–163 (1995).
CAS PubMed Google Scholar
- Elzey, B.D., Siemens, D.R., Ratliff, T.L. & Lubaroff, D.M. Immunization with type 5 adenovirus recombinant for a tumor antigen in combination with recombinant canarypox virus (ALVAC) cytokine gene delivery induces destruction of established prostate tumors. Int. J. Cancer 94, 842–849 (2001).
Article CAS Google Scholar
- Adler, A.J. et al. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J. Exp. Med. 187, 1555–1564 (1998).
Article CAS Google Scholar
- Adler, A.J., Huang, C.T., Yochum, G.S., Marsh, D.W. & Pardoll, D.M. In vivo CD4+ T cell tolerance induction versus priming is independent of the rate and number of cell divisions. J. Immunol. 164, 649–655 (2000).
Article CAS Google Scholar
- Huang, C.T. et al. CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction. J. Immunol. 170, 3945–3953 (2003).
Article CAS Google Scholar
- Morgan, D.J. et al. CD8+ T cell-mediated spontaneous diabetes in neonatal mice. J. Immunol. 157, 978–983 (1996).
CAS PubMed Google Scholar
- Hernandez, J., Aung, S., Redmond, W.L. & Sherman, L.A. Phenotypic and functional analysis of CD8+ T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med. 194, 707–717 (2001).
Article CAS Google Scholar
- Morgan, D.J., Kreuwel, H.T. & Sherman, L.A. Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens. J. Immunol. 163, 723–727 (1999).
CAS PubMed Google Scholar
- Shortman, K. & Liu, Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2, 151–161 (2002).
Article CAS Google Scholar
- Moser, M. Dendritic cells in immunity and tolerance—do they display opposite functions? Immunity 19, 5–8 (2003).
Article CAS Google Scholar
- Onizuka, S. et al. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody. Cancer Res. 59, 3128–3133 (1999).
CAS PubMed Google Scholar
- Pasare, C. & Medzhitov, R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033–1036 (2003).
Article CAS Google Scholar
- Ochsenbein, A.F. et al. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature 411, 1058–1064 (2001).
Article CAS Google Scholar
- Lohr, J., Knoechel, B., Jiang, S., Sharpe, A.H. & Abbas, A.K. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat. Immunol. 4, 664–669 (2003).
Article CAS Google Scholar
- Oldenhove, G. et al. CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J. Exp. Med. 198, 259–266 (2003).
Article CAS Google Scholar
- Serra, P. et al. CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity 19, 877–889 (2003).
Article CAS Google Scholar
- Vaidya, S.A. & Cheng, G. Toll-like receptors and innate antiviral responses. Curr. Opin. Immunol. 15, 402–407 (2003).
Article CAS Google Scholar
- Kurt-Jones, E.A. et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1, 398–401 (2000).
Article CAS Google Scholar
- Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732–738 (2001).
Article CAS Google Scholar
- Yang, Y., Greenough, K. & Wilson, J.M. Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther. 3, 412–420 (1996).
CAS PubMed Google Scholar
- Amara, R.R. et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292, 69–74 (2001).
Article CAS Google Scholar
- Overwijk, W.W. et al. Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4+ T lymphocytes. Proc. Natl. Acad. Sci. USA 96, 2982–2987 (1999).
Article CAS Google Scholar
- Klein, C., Bueler, H. & Mulligan, R.C. Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines. J. Exp. Med. 191, 1699–1708 (2000).
Article CAS Google Scholar
- Miyoshi, H., Blomer, U., Takahashi, M., Gage, F.H. & Verma, I.M. Development of a self-inactivating lentivirus vector. J. Virol. 72, 8150–8157 (1998).
CAS PubMed PubMed Central Google Scholar
- Aliberti, J., Hieny, S., Reis e Sousa, C., Serhan, C.N. & Sher, A. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat. Immunol. 3, 76–82 (2002).
Article CAS Google Scholar