Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages (original) (raw)
Mosmann, T. & Coffman, R. Th1 and Th2 cells: Different patterns of lymphokine secretion leads to different functional properties. Annu. Rev. Immunol.7, 145–173 (1989). ArticleCAS Google Scholar
Bottomly, K. A functional dichotomy in CD4+ T lymphocytes. Immunol. Today9, 268–277 (1988). ArticleCAS Google Scholar
Murphy, K.M. & Reiner, S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol.2, 933–944 (2002). ArticleCAS Google Scholar
Robinson, D.S. & O'Garra, A. Further checkpoints in Th1 development. Immunity16, 755–758 (2002). ArticleCAS Google Scholar
Ansel, K.M., Lee, D.U. & Rao, A. An epigenetic view of helper T cell differentiation. Nat. Immunol.4, 616–623 (2003). ArticleCAS Google Scholar
Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med.185, 817–824 (1997). ArticleCAS Google Scholar
Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity9, 745–755 (1998). ArticleCAS Google Scholar
Pflanz, S. et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity16, 779–790 (2002). ArticleCAS Google Scholar
Zheng, W. & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell89, 587–596 (1997). CAS Google Scholar
Ouyang, W. et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity12, 27–37 (2000). ArticleCAS Google Scholar
Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med.201, 233–240 (2005). ArticleCAS Google Scholar
Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature421, 744–748 (2003). ArticleCAS Google Scholar
Murphy, C.A. et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med.198, 1951–1957 (2003). ArticleCAS Google Scholar
Aggarwal, S., Ghilardi, N., Xie, M.H., de Sauvage, F.J. & Gurney, A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem.278, 1910–1914 (2003). ArticleCAS Google Scholar
Gran, B. et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol.169, 7104–7110 (2002). ArticleCAS Google Scholar
Bettelli, E. & Kuchroo, V.K. IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J. Exp. Med.201, 169–171 (2005). ArticleCAS Google Scholar
Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity13, 715–725 (2000). ArticleCAS Google Scholar
Parham, C. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol.168, 5699–5708 (2002). ArticleCAS Google Scholar
Langrish, C.L. et al. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev.202, 96–105 (2004). ArticleCAS Google Scholar
Lucas, S., Ghilardi, N., Li, J. & de Sauvage, F.J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. USA100, 15047–15052 (2003). ArticleCAS Google Scholar
Hibbert, L., Pflanz, S., De Waal Malefyt, R. & Kastelein, R.A. IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-Bet and IL-12Rβ2 in naive T cells. J. Interferon Cytokine Res.23, 513–522 (2003). ArticleCAS Google Scholar
Ferber, I.A. et al. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol.156, 5–7 (1996). CAS Google Scholar
Willenborg, D.O., Fordham, S., Bernard, C.C., Cowden, W.B. & Ramshaw, I.A. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol.157, 3223–3227 (1996). CAS Google Scholar
Kolls, J.K. & Linden, A. Interleukin-17 family members and inflammation. Immunity21, 467–476 (2004). ArticleCAS Google Scholar
Huang, S. et al. Immune response in mice that lack the interferon-γ receptor. Science259, 1742–1745 (1993). ArticleCAS Google Scholar
Dalton, D.K. et al. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science259, 1739–1742 (1993). ArticleCAS Google Scholar
Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell100, 655–669 (2000). ArticleCAS Google Scholar
Lighvani, A.A. et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA98, 15137–15142 (2001). ArticleCAS Google Scholar
Mullen, A.C. et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science292, 1907–1910 (2001). ArticleCAS Google Scholar
Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol.3, 549–557 (2002). ArticleCAS Google Scholar
Cho, J.Y., Grigura, V., Murphy, T.L. & Murphy, K. Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. Int. Immunol.15, 1149–1160 (2003). ArticleCAS Google Scholar
Szabo, S.J. et al. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science295, 338–342 (2002). ArticleCAS Google Scholar
Murphy, E. et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med.183, 901–913 (1996). ArticleCAS Google Scholar
Berenson, L.S., Ota, N. & Murphy, K.M. Issues in T-helper 1 development–resolved and unresolved. Immunol. Rev.202, 157–174 (2004). ArticleCAS Google Scholar
Bettelli, E. et al. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med.200, 79–87 (2004). ArticleCAS Google Scholar
Chitnis, T. et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest.108, 739–747 (2001). ArticleCAS Google Scholar
Lovett-Racke, A.E. et al. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity21, 719–731 (2004). ArticleCAS Google Scholar
Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity17, 375–387 (2002). ArticleCAS Google Scholar
Ghilardi, N. et al. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol.172, 2827–2833 (2004). ArticleCAS Google Scholar
Happel, K.I. et al. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J. Immunol.170, 4432–4436 (2003). ArticleCAS Google Scholar
Ye, P. et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med.194, 519–527 (2001). ArticleCAS Google Scholar
Smits, H.H. et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur. J. Immunol.34, 1371–1380 (2004). ArticleCAS Google Scholar
Berg, D.J. et al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ TH1-like responses. J. Clin. Invest.98, 1010–1020 (1996). ArticleCAS Google Scholar
Magram, J. et al. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity4, 471–481 (1996). ArticleCAS Google Scholar
Shinkai, Y. et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science259, 822–825 (1993). ArticleCAS Google Scholar
Murphy, K.M., Heimberger, A.B. & Loh, D.Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science250, 1720–1723 (1990). ArticleCAS Google Scholar
Meraz, M.A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell84, 431–442 (1996). ArticleCAS Google Scholar
Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity8, 177–187 (1998). ArticleCAS Google Scholar
Kubo, T. et al. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J. Immunol.173, 7249–7258 (2004). ArticleCAS Google Scholar