Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self (original) (raw)

• Kyewski, B. & Klein, L. A central role for central tolerance. Annu. Rev. Immunol. 24, 571–606 (2006).
  Article CAS Google Scholar
• Gallegos, A.M. & Bevan, M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039–1049 (2004).
  Article CAS Google Scholar
• Gallegos, A.M. & Bevan, M.J. Central tolerance: good but imperfect. Immunol. Rev. 209, 290–296 (2006).
  Article Google Scholar
• Klein, L. & Kyewski, B. Self-antigen presentation by thymic stromal cells: a subtle division of labor. Curr. Opin. Immunol. 12, 179–186 (2000).
  Article CAS Google Scholar
• Redmond, W.L. & Sherman, L.A. Peripheral tolerance of CD8 T lymphocytes. Immunity 22, 275–284 (2005).
  Article CAS Google Scholar
• Heath, W.R. & Carbone, F.R. Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19, 47–64 (2001).
  Article CAS Google Scholar
• Steinman, R.M. et al. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann. NY Acad. Sci. 987, 15–25 (2003).
  Article CAS Google Scholar
• Kurts, C. et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923–930 (1996).
  Article CAS Google Scholar
• Adler, A.J. et al. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J. Exp. Med. 187, 1555–1564 (1998).
  Article CAS Google Scholar
• Morgan, D.J. et al. Ontogeny of T cell tolerance to peripherally expressed antigens. Proc. Natl. Acad. Sci. USA 96, 3854–3858 (1999).
  Article CAS Google Scholar
• Belz, G.T. et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196, 1099–1104 (2002).
  Article CAS Google Scholar
• Vezys, V., Olson, S. & Lefrancois, L. Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity 12, 505–514 (2000).
  Article CAS Google Scholar
• Mayerova, D., Parke, E.A., Bursch, L.S., Odumade, O.A. & Hogquist, K.A. Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state. Immunity 21, 391–400 (2004).
  Article CAS Google Scholar
• Azukizawa, H. et al. Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes. Eur. J. Immunol. 33, 1879–1888 (2003).
  Article CAS Google Scholar
• Scheinecker, C., McHugh, R., Shevach, E.M. & Germain, R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196, 1079–1090 (2002).
  Article CAS Google Scholar
• Kelsall, B.L. & Leon, F. Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease. Immunol. Rev. 206, 132–148 (2005).
  Article CAS Google Scholar
• Izcue, A., Coombes, J.L. & Powrie, F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212, 256–271 (2006).
  Article CAS Google Scholar
• Lefrancois, L. & Puddington, L. Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo. Annu. Rev. Immunol. 24, 681–704 (2006).
  Article CAS Google Scholar
• Vermaelen, K.Y., Carro-Muino, I., Lambrecht, B.N. & Pauwels, R.A. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193, 51–60 (2001).
  Article CAS Google Scholar
• Turley, S., Poirot, L., Hattori, M., Benoist, C. & Mathis, D. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J. Exp. Med. 198, 1527–1537 (2003).
  Article CAS Google Scholar
• Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17–27 (1994).
  Article CAS Google Scholar
• van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423–429 (2001).
  Article CAS Google Scholar
• Kaech, S.M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415–422 (2001).
  Article CAS Google Scholar
• Bevan, M.J. & Fink, P.J. The CD8 response on autopilot. Nat. Immunol. 2, 381–382 (2001).
  Article CAS Google Scholar
• Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355–360 (2004).
  Article CAS Google Scholar
• Lindquist, R.L. et al. Visualizing dendritic cell networks in vivo. Nat. Immunol. 5, 1243–1250 (2004).
  Article CAS Google Scholar
• Limmer, A. et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat. Med. 6, 1348–1354 (2000).
  Article CAS Google Scholar
• Arnold, B. Parenchymal cells in immune and tolerance induction. Immunol. Lett. 89, 225–228 (2003).
  Article CAS Google Scholar
• Staton, T.L. et al. CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat. Immunol. 7, 482–488 (2006).
  Article CAS Google Scholar
• Cose, S., Brammer, C., Khanna, K.M., Masopust, D. & Lefrancois, L. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur. J. Immunol. 36, 1423–1433 (2006).
  Article CAS Google Scholar
• Johnstone, C.N. et al. Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G500–G510 (2000).
  Article CAS Google Scholar
• Abud, H.E., Johnstone, C.N., Tebbutt, N.C. & Heath, J.K. The murine A33 antigen is expressed at two distinct sites during development, the ICM of the blastocyst and the intestinal epithelium. Mech. Dev. 98, 111–114 (2000).
  Article CAS Google Scholar
• Anderson, M.S. et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227–239 (2005).
  Article CAS Google Scholar
• Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395–1401 (2002).
  Article CAS Google Scholar
• Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032–1039 (2001).
  Article CAS Google Scholar
• Maemura, K. et al. Antigen-presenting cells expressing glutamate decarboxylase 67 were identified as epithelial cells in glutamate decarboxylase 67-GFP knock-in mouse thymus. Tissue Antigens 67, 198–206 (2006).
  Article CAS Google Scholar
• Hecht, N.B. The making of a spermatozoon: a molecular perspective. Dev. Genet. 16, 95–103 (1995).
  Article CAS Google Scholar
• Garcia, C.A. et al. Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion. J. Immunol. 175, 2111–2122 (2005).
  Article CAS Google Scholar
• Delamarre, L., Pack, M., Chang, H., Mellman, I. & Trombetta, E.S. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307, 1630–1634 (2005).
  Article CAS Google Scholar
• Steinman, R.M. The control of immunity and tolerance by dendritic cell. Pathol. Biol. (Paris) 51, 59–60 (2003).
  Article CAS Google Scholar
• Heath, W.R., Kurts, C., Miller, J.F. & Carbone, F.R. Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J. Exp. Med. 187, 1549–1553 (1998).
  Article CAS Google Scholar
• Rescigno, M. et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2, 361–367 (2001).
  Article CAS Google Scholar
• Vallon-Eberhard, A., Landsman, L., Yogev, N., Verrier, B. & Jung, S. Transepithelial pathogen uptake into the small intestinal lamina propria. J. Immunol. 176, 2465–2469 (2006).
  Article CAS Google Scholar
• Huang, F.P. et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191, 435–444 (2000).
  Article CAS Google Scholar
• Macpherson, A.J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662–1665 (2004).
  Article CAS Google Scholar
• Turley, S.J., Lee, J-W., Dutton-Swain, N., Mathis, D. & Benoist, C. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc. Natl. Acad. Sci. USA 102, 17729–17733 (2005).
  Article CAS Google Scholar