Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation (original) (raw)
Harty, J. T., Tvinnereim, A. R. & White, D. W. CD8+ T cell effector mechanisms in resistance to infection. Annu. Rev. Immunol.18, 275–308 (2000). ArticleCAS Google Scholar
Bevan, M. J. Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med.182, 639–641 (1995). ArticleCAS Google Scholar
Lanzavecchia, A. From antigen presentation to T-cell activation. Res. Immunol.149, 626 (1998). ArticleCAS Google Scholar
Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol18, 767–811 (2000). ArticleCAS Google Scholar
Heath, W. R., Kurts, C., Miller, J. & Carbone, F. R. Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens. J. Exp. Med.187, 1549–1553 (1998). ArticleCAS Google Scholar
Garza, K. M. et al. Role of Antigen-presenting Cells in Mediating Tolerance and Autoimmunity. J. Exp. Med.191, 2021–2028 (2000). ArticleCAS Google Scholar
Sotomayor, E. M. et al. Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nature Med.5, 780–787 (1999). ArticleCAS Google Scholar
Keene, J. & Forman, J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med.155, 768–782 (1982). ArticleCAS Google Scholar
Bennett, S. R. M., Carbone, F. R., Karamalis, F., Miller, J. F. A. P. & Heath, W. R. Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J. Exp. Med.186, 65–70 (1997). ArticleCAS Google Scholar
Schoenberger, S. P. et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature393, 480–483 (1998). ArticleCAS Google Scholar
Bennett, S. R. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signaling. Nature393 478–480 (1998). ArticleCAS Google Scholar
Ridge, J. P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature393, 474–478 (1998). ArticleCAS Google Scholar
Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nature Med.5, 1249–1255 (1999). ArticleCAS Google Scholar
Cella, M. et al. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med.189, 821–829 (1999). ArticleCAS Google Scholar
Sauter, B. et al. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med.191, 423–434 (2000). ArticleCAS Google Scholar
Binder, R. J., Anderson, K. M., Basu, S. & Srivastava, P. K. Cutting edge: heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo. J. Immunol.165, 6029–6035 (2000). ArticleCAS Google Scholar
Basu, S., Binder, R. J., Suto, R., Anderson, K. M. & Srivastava, P. K. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway. Int. Immunol.12, 1539–1546 (2000). ArticleCAS Google Scholar
Lafferty, K. J. & Cunningham, A. J. A new analysis of allogeneic interactions. Aust. J. Exp. Biol. Med. Sci.53, 27–42 (1975). ArticleCAS Google Scholar
Slavik, J. M., Hutchcroft, J. E. & Bierer, B. E. CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol. Res.19, 1–24 (1999). ArticleCAS Google Scholar
Lanzavecchia, A. & Sallusto, F. From synapses to immunological memory: the role of sustained T cell stimulation. Curr. Opin. Immunol.12, 92–98 (2000). ArticleCAS Google Scholar
Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science283, 680–682 (1999). ArticleCAS Google Scholar
Borriello, F. et al. B7–1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity6, 303–313 (1997). ArticleCAS Google Scholar
McAdam, A. J., Farkash, E. A., Gewurz, B. E. & Sharpe, A. H. B7 costimulation is critical for antibody class switching and CD8+ cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J. Virol.74, 203–208 (2000). ArticleCAS Google Scholar
McAdam, A. J., Gewurz, B. E., Farkash, E. A. & Sharpe, A. H. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. J. Immunol.165, 3088–3093 (2000). ArticleCAS Google Scholar
Santra, S. et al. Functional Equivalency of B7–1 and B7-2 for Costimulating Plasmid DNA Vaccine-Elicited CTL Responses. J. Immunol.165, 6791–6795 (2000). ArticleCAS Google Scholar
Lanzavecchia, A. Dendritic cell maturation and generation of immune responses. Haematologica84, 23–25 (1999). PubMed Google Scholar
Schoenberger, S. P. et al. Efficient direct priming of tumor-specific cytotoxic T lymphocyte in vivo by an engineered APC. Cancer. Res.58, 3094–3100 (1998). CASPubMed Google Scholar
Sanderson, S. & Shastri, N. LacZ inducible, antigen/MHC-specific T cell hybrids. Int. Immunol.6, 369–376 (1994). ArticleCAS Google Scholar
Hogquist, K. A. et al. T cell receptor antagonist peptides induce positive selection. Cell76, 17–27 (1994). ArticleCAS Google Scholar
Lyons, A. B. Divided we stand: tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester. Immunol. Cell Biol.77, 509–515 (1999). ArticleCAS Google Scholar
Huang, J. F. et al. TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. Science286, 952–954 (1999). ArticleCAS Google Scholar
Hwang, I. et al. T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J. Exp. Med.191, 1137–1148 (2000). ArticleCAS Google Scholar
Nikolic-Zugic, J. & Bevan, M. J. Role of self-peptides in positively selecting the T-cell repertoire. Nature344, 65–67 (1990). ArticleCAS Google Scholar
Bronstein-Sitton, N., Wang, L., Cohen, L. & Baniyash, M. Expression of the T cell antigen receptor ζ chain following activation is controlled at distinct checkpoints. Implications for cell surface receptor down-modulation and re-expression. J. Biol. Chem.274, 23659–23665 (1999). ArticleCAS Google Scholar
San Jose, E., Borroto, A., Niedergang, F., Alcover, A. & Alarcon, B. Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism. Immunity12, 161–170 (2000). ArticleCAS Google Scholar
Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science273, 104–106 (1996). ArticleCAS Google Scholar
Swain, S. L. Lymphokines and the immune response: the central role of interleukin-2. Curr. Opin. Immunol.3, 304–310 (1991). ArticleCAS Google Scholar
Jelley-Gibbs, D. M., Lepak, N. M., Yen, M. & Swain, S. L. Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation. J. Immunol.165, 5017–5026 (2000). ArticleCAS Google Scholar
Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity8, 89–95 (1998). ArticleCAS Google Scholar
Karttunen, J. & Shastri, N. Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc. Natl Acad. Sci. USA88. 3972–3976 (1991). ArticleCAS Google Scholar
Veiga-Fernandes, H., U., W., Bourgeois, C., McLean, A. & Rocha, B. Response of naive and memory CD8+ T cells to antigen stimulation in vivo. Nature Immunol.1, 47–53 (2000). ArticleCAS Google Scholar
Staudt, L. M. & Brown, P. O. Genomic views of the immune system. Annu. Rev. Immunol.18, 829–859 (2000). ArticleCAS Google Scholar
Murali-Krishna, K. et al. In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection. Adv. Exp. Med. Biol.452, 123–142 (1998). ArticleCAS Google Scholar
Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity8, 177–187 (1998). ArticleCAS Google Scholar
Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. A. P. & Heath, W. R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med.186, 239–245 (1997). ArticleCAS Google Scholar
Zhang, J., MacLennan, I. C., Liu, Y. J. & Lane, P. J. Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones? Immunol. Lett.18, 297–299 (1988). ArticleCAS Google Scholar
Matzinger, P. The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Meth.145, 185–192 (1991). ArticleCAS Google Scholar