Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement (original) (raw)
Francis, N.J. & Kingston, R.E. Mechanisms of transcriptional memory. Nat Rev. Mol. Cell Biol.2, 409–421 (2001). ArticleCASPubMed Google Scholar
Mahmoudi, T. & Verrijzer, C.P. Chromatin silencing and activation by Polycomb and trithorax group proteins. Oncogene20, 3055–3066 (2001). ArticleCASPubMed Google Scholar
Franke, A et al. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J.11, 2941–2950 (1992). ArticleCASPubMedPubMed Central Google Scholar
van Lohuizen, M. et al. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol. Cell. Biol.18, 3572–3579 (1998). ArticleCASPubMedPubMed Central Google Scholar
Sewalt, R.G. et al. Characterization of interactions between the mammalian polycomb-group proteins Enx1/Ezh2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol. Cell. Biol.18, 3586–3595 (1998). ArticleCASPubMedPubMed Central Google Scholar
Shao, Z. et al. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell98, 37–46 (1999). ArticleCASPubMed Google Scholar
Gould, A Functions of mammalian Polycomb group and trithorax group related genes. Curr. Opin. Genet.7, 488–494 (1997). ArticleCAS Google Scholar
van der Lugt, N.M. et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev.8, 757–769 (1994). ArticleCASPubMed Google Scholar
Katoh-Fukui, Y. et al. Male-to-female sex reversal in M33 mutant mice. Nature393, 688–692 (1998). ArticleCASPubMed Google Scholar
Akasaka, T. et al. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity7, 135–146 (1997). ArticleCASPubMed Google Scholar
Tokimasa, S. et al. Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage. Exp. Hematol.29, 93–103 (2001). ArticleCASPubMed Google Scholar
Core, N. et al. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development124, 721–729 (1997). CASPubMed Google Scholar
Hobert, O., Jallal, B. & Ullrich, A. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol. Cell. Biol.16, 3066–3073 (1996). ArticleCASPubMedPubMed Central Google Scholar
Hobert, O., Sures, I., Ciossek, T., Fuchs, M. & Ullrich, A. Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene. Mech. Dev.55, 171–184 (1996). ArticleCASPubMed Google Scholar
Czermin, B. et al. Drosophila enhancer of zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb Sites. Cell111, 185–196 (2002). ArticleCASPubMed Google Scholar
Muller, J. et al. Histone methyltransferase activity of a Drosophila polycomb group repressor complex. Cell111, 197–208 (2002). ArticleCASPubMed Google Scholar
Cao, R. et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science298, 1039–1043 (2002). ArticleCASPubMed Google Scholar
Kouzarides, T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev.12, 198–209 (2002). ArticleCASPubMed Google Scholar
Raaphorst, F.M. et al. Coexpression of BMI-1 and Ezh2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease. Am. J. Pathol.157, 709–715 (2000). ArticleCASPubMedPubMed Central Google Scholar
Fukuyama, T. et al. Proliferative involvement of ENX-1, a putative human polycomb group gene, in haematopoietic cells. Br. J. Haematol.108, 842–847 (2000). ArticleCASPubMed Google Scholar
Gu, H., Zou, Y.R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell73, 1155–1164 (1993). ArticleCASPubMed Google Scholar
Laible, G. et al. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J.16, 3219–3232 (1997). ArticleCASPubMedPubMed Central Google Scholar
Tschiersch, B. et al. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J.13, 3822–3831 (1994). ArticleCASPubMedPubMed Central Google Scholar
Carrington, E.A. & Jones, R.S. The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution. Development122, 4073–4083 (1996). CASPubMed Google Scholar
Kühn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science269, 1427–1429 (1995). ArticlePubMed Google Scholar
Baird, A.M., Gerstein, R.M. & Berg, L.J. The role of cytokine receptor signaling in lymphocyte development. Curr. Opin. Immunol.11, 157–166 (1999). ArticleCASPubMed Google Scholar
Kitamura, D., Roes, J., Kühn, R. & Rajewsky, K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature350, 423–426 (1991). ArticleCASPubMed Google Scholar
Sonoda, E. et al. B cell development under the condition of allelic inclusion. Immunity6, 225–233 (1997). ArticleCASPubMed Google Scholar
Rickert, R.C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res.25, 1317–1318 (1997). ArticleCASPubMedPubMed Central Google Scholar
Wu, G.E. & Paige, C.J. VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay. EMBO J.5, 3475–3481 (1986). ArticleCASPubMedPubMed Central Google Scholar
Connor, A.M. et al. Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558. J. Immunol.155, 5268–5272 (1995). CASPubMed Google Scholar
Ehlich A. et al. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell72, 695–704 (1993). ArticleCASPubMed Google Scholar
Schlissel, M.S. & Stanhope-Baker, P. Accessibility and the developmental regulation of V(D)J recombination. Semin. Immunol.9, 161–170 (1997). ArticleCASPubMed Google Scholar
Grawunder, U. & Harfst, E. How to make ends meet in V(D)J recombination. Curr. Opin. Immunol.13, 186–194 (2001). ArticleCASPubMed Google Scholar
Malynn, B.A., Yancopoulos, G.D., Barth, J.E., Bona, C.A. & Alt, F.W. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J. Exp. Med.171, 843–859 (1990). ArticleCASPubMed Google Scholar
Lin, W.C. & Desiderio, S. V(D)J recombination and the cell cycle. Immunol. Today16, 279–289 (1995). ArticleCASPubMed Google Scholar
Corcoran, A.E., Riddell, A., Krooshoop, D. & Venkitaraman, A.R. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature391, 904–907 (1998). ArticleCASPubMed Google Scholar
Hofmeister, R. et al. Interleukin-7: physiological roles and mechanisms of action. Cytokine Growth Factor Rev.10, 41–60 (1999). ArticleCASPubMed Google Scholar
Krutchinsky, A.N., Kalkum, M. & Chait, B.T. Automatic identification of proteins with a MALDI-quadrupole ion trap mass spectrometer. Anal. Chem.73, 5066–5077 (2001). ArticleCASPubMed Google Scholar
Krutchinsky, A.N., Zhang, W. & Chait, B.T. Rapidly switchable matrix-assisted laser desorption/ionization and electrospray quadrupole-time-of-flight mass spectrometry for protein identification. J. Am. Soc. Mass Spectrom.11, 493–504 (2000). ArticleCASPubMed Google Scholar
Bannister, A.J., Schneider, R. & Kouzarides, T. Histone methylation: dynamic or static? Cell109, 801–806 (2002). ArticleCASPubMed Google Scholar
Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature403, 41–45 (2000). ArticleCASPubMed Google Scholar
Bird, A.W. et al. Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature419, 411–415 (2002). ArticleCASPubMed Google Scholar
Taverna, S.D., Coyne, R.S. & Allis, C.D. Methylation of histone H3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell110, 701–711 (2002). ArticleCASPubMed Google Scholar
Torres, R.M. & Kühn, R. Cre/loxP recombination system and gene targeting. Meth. Mol. Biol.180, 175–204 (2002). Google Scholar
Mecklenbräuker, I., Saijo, K., Zheng, N.Y., Leitges, M. & Tarakhovsky, A. Protein kinase Cδ controls self-antigen-induced B-cell tolerance. Nature416, 860–865 (2002). ArticlePubMedCAS Google Scholar
Sambrook, J., Fritsch, E.F. & Maniatis, T. Molecular Cloning (Cold Spring Harbor Laboratory Press, New York, 1989). Google Scholar