Netting neutrophils in autoimmune small-vessel vasculitis (original) (raw)

This is a preview of subscription content, access via your institution

References

  1. Jennette, J.C. & Falk, R.J. N. Engl. J. Med. 337, 1512–1523 (1997).
    Article CAS Google Scholar
  2. Kallenberg, C.G.M., Heeringa, P. & Stegeman, C.A. Nat. Clin. Pract. Rheumatol. 2, 661–670 (2006).
    Article CAS Google Scholar
  3. Falk, R.J., Terrell, R.S., Charles, L.A. & Jennette, J.C. Proc. Natl. Acad. Sci. USA 87, 4115–4119 (1990).
    Article CAS Google Scholar
  4. Pfister, H. et al. Blood 104, 1411–1418 (2004).
    Article CAS Google Scholar
  5. Xiao, H. et al. J. Clin. Invest. 110, 955–963 (2002).
    Article CAS Google Scholar
  6. Brinkmann, V. et al. Science 303, 1532–1535 (2004).
    Article CAS Google Scholar
  7. Clark, S.R. et al. Nat. Med. 13, 463–469 (2007).
    Article CAS Google Scholar
  8. Fuchs, T.A. et al. J. Cell Biol. 176, 231–241 (2007).
    Article CAS Google Scholar
  9. Harper, L., Ren, Y., Savill, J., Adu, D. & Savage, C.O.S. Am. J. Pathol. 157, 211–220 (2000).
    Article CAS Google Scholar
  10. Yousefi, S. et al. Nat. Med. 14, 949–953 (2008).
    Article CAS Google Scholar
  11. Murao, S., Stevens, F.J., Ito, A. & Huberman, E. Proc. Natl. Acad. Sci. USA 85, 1232–1236 (1988).
    Article CAS Google Scholar
  12. Lande, R. et al. Nature 449, 564–569 (2007).
    Article CAS Google Scholar
  13. Woltman, A.M. et al. Kidney Int. 71, 1001–1008 (2007).
    Article CAS Google Scholar
  14. Wenzel, J. et al. J. Pathol. 205, 435–442 (2005).
    Article CAS Google Scholar
  15. Holdenrieder, S. et al. Ann. NY Acad. Sci. 1075, 318–327 (2006).
    Article CAS Google Scholar
  16. Leadbetter, E.A. et al. Nature 416, 603–607 (2002).
    Article CAS Google Scholar

Download references

Acknowledgements

We would like to thank W. Samtleben for providing serum samples, R. Bittner for technical assistance and E. Csernok and A. Kniepert for help with serum samples. Moreover, we are grateful to M. Sixt and E. Meinl for helpful suggestions and H. Wekerle for his constant interest and support of this work. We also thank M. Monestier (Temple University) for providing us with histone-specific monoclonal antibody and G. Koch (University of Freiburg) for the kind gift of the antibody specific for MxA. This work was funded by the Deutsche Forschungsgemeinschaft (SFB 571). It was further supported by the US National Institutes of Health (AI053194) and by fellowships from the Susan G. Komen for the Cure Foundation and the Alexander von Humboldt Foundation.

Author information

Authors and Affiliations

  1. Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, Martinsried, Germany
    Kai Kessenbrock, Markus Krumbholz & Dieter E Jenne
  2. Department of Anatomy, University of California, San Francisco, California, USA
    Kai Kessenbrock & Zena Werb
  3. Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
    Markus Krumbholz
  4. Nephrology Division, Medical Clinic I, University Hospital Großhadern, Munich, Germany
    Ulf Schönermarck
  5. Department of Pathology, Mannheim Clinics, University of Heidelberg, Mannheim, Germany
    Walter Back
  6. Department of Rheumatology, University of Lübeck, Vasculitis Center Universitaetsklinikum Schleswig-Holstein and Rheumaklinik Bad Bramstedt, Lübeck, Germany
    Wolfgang L Gross
  7. Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    Hermann-Josef Gröne
  8. Microscopy Core Facility, Max Planck Institute for Infection Biology, Charitéplatz 1, Berlin, Germany
    Volker Brinkmann

Authors

  1. Kai Kessenbrock
    You can also search for this author inPubMed Google Scholar
  2. Markus Krumbholz
    You can also search for this author inPubMed Google Scholar
  3. Ulf Schönermarck
    You can also search for this author inPubMed Google Scholar
  4. Walter Back
    You can also search for this author inPubMed Google Scholar
  5. Wolfgang L Gross
    You can also search for this author inPubMed Google Scholar
  6. Zena Werb
    You can also search for this author inPubMed Google Scholar
  7. Hermann-Josef Gröne
    You can also search for this author inPubMed Google Scholar
  8. Volker Brinkmann
    You can also search for this author inPubMed Google Scholar
  9. Dieter E Jenne
    You can also search for this author inPubMed Google Scholar

Contributions

K.K. performed most of the experiments. M.K. performed IFN-α ELISA and contributed to data analysis and discussion. U.S., W.B. and W.L.G. provided patient material and clinical data. Z.W. provided critical input on data analysis. H.-J.G. provided kidney biopsies and clinical data. H.-J.G. and V.B. performed immunostainings and analysis of histology. K.K. and D.E.J. designed and supervised the study, analyzed data and wrote the manuscript. D.E.J. secured the funding. All authors discussed results and commented on the manuscript.

Corresponding authors

Correspondence toKai Kessenbrock or Dieter E Jenne.

Supplementary information

Rights and permissions

About this article

Cite this article

Kessenbrock, K., Krumbholz, M., Schönermarck, U. et al. Netting neutrophils in autoimmune small-vessel vasculitis.Nat Med 15, 623–625 (2009). https://doi.org/10.1038/nm.1959

Download citation