Netting neutrophils in autoimmune small-vessel vasculitis (original) (raw)
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Acknowledgements
We would like to thank W. Samtleben for providing serum samples, R. Bittner for technical assistance and E. Csernok and A. Kniepert for help with serum samples. Moreover, we are grateful to M. Sixt and E. Meinl for helpful suggestions and H. Wekerle for his constant interest and support of this work. We also thank M. Monestier (Temple University) for providing us with histone-specific monoclonal antibody and G. Koch (University of Freiburg) for the kind gift of the antibody specific for MxA. This work was funded by the Deutsche Forschungsgemeinschaft (SFB 571). It was further supported by the US National Institutes of Health (AI053194) and by fellowships from the Susan G. Komen for the Cure Foundation and the Alexander von Humboldt Foundation.
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Authors and Affiliations
- Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, Martinsried, Germany
Kai Kessenbrock, Markus Krumbholz & Dieter E Jenne - Department of Anatomy, University of California, San Francisco, California, USA
Kai Kessenbrock & Zena Werb - Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
Markus Krumbholz - Nephrology Division, Medical Clinic I, University Hospital Großhadern, Munich, Germany
Ulf Schönermarck - Department of Pathology, Mannheim Clinics, University of Heidelberg, Mannheim, Germany
Walter Back - Department of Rheumatology, University of Lübeck, Vasculitis Center Universitaetsklinikum Schleswig-Holstein and Rheumaklinik Bad Bramstedt, Lübeck, Germany
Wolfgang L Gross - Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
Hermann-Josef Gröne - Microscopy Core Facility, Max Planck Institute for Infection Biology, Charitéplatz 1, Berlin, Germany
Volker Brinkmann
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- Kai Kessenbrock
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Contributions
K.K. performed most of the experiments. M.K. performed IFN-α ELISA and contributed to data analysis and discussion. U.S., W.B. and W.L.G. provided patient material and clinical data. Z.W. provided critical input on data analysis. H.-J.G. provided kidney biopsies and clinical data. H.-J.G. and V.B. performed immunostainings and analysis of histology. K.K. and D.E.J. designed and supervised the study, analyzed data and wrote the manuscript. D.E.J. secured the funding. All authors discussed results and commented on the manuscript.
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Correspondence toKai Kessenbrock or Dieter E Jenne.
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Kessenbrock, K., Krumbholz, M., Schönermarck, U. et al. Netting neutrophils in autoimmune small-vessel vasculitis.Nat Med 15, 623–625 (2009). https://doi.org/10.1038/nm.1959
- Received: 24 October 2008
- Accepted: 06 April 2009
- Published: 17 May 2009
- Issue Date: June 2009
- DOI: https://doi.org/10.1038/nm.1959