The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance (original) (raw)
Dixit, V.D. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J. Leukoc. Biol.84, 882–892 (2008). ArticleCASPubMedPubMed Central Google Scholar
Odegaard, J.I. & Chawla, A. Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat. Clin. Pract. Endocrinol. Metab.4, 619–626 (2008). ArticleCASPubMedPubMed Central Google Scholar
Lumeng, C.N., Bodzin, J.L. & Saltiel, A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest.117, 175–184 (2007). ArticleCASPubMedPubMed Central Google Scholar
Patsouris, D. et al. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab.8, 301–309 (2008). ArticleCASPubMedPubMed Central Google Scholar
Arkan, M.C. et al. IKK-β links inflammation to obesity-induced insulin resistance. Nat. Med.11, 191–198 (2005). ArticleCASPubMed Google Scholar
Jager, J., Grémeaux, T., Cormont, M., Le Marchand-Brustel, Y. & Tanti, J.F. Interleukin-1β–induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology148, 241–251 (2007). ArticleCASPubMed Google Scholar
Larsen, C.M. et al. Interleukin-1–receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med.356, 1517–1526 (2007). ArticleCASPubMed Google Scholar
Osborn, O. et al. Treatment with an Interleukin 1 β antibody improves glycemic control in diet-induced obesity. Cytokine44, 141–148 (2008). ArticleCASPubMedPubMed Central Google Scholar
Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature449, 819–826 (2007). ArticleCASPubMed Google Scholar
Barton, G.M. & Kagan, J.C. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol.9, 535–542 (2009). ArticleCASPubMedPubMed Central Google Scholar
Agostini, L. et al. NLRP3 forms an IL-1β–processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity20, 319–325 (2004). ArticleCASPubMed Google Scholar
Lamkanfi, M. & Dixit, V.M. Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev.227, 95–105 (2009). ArticleCASPubMed Google Scholar
Franchi, L., Eigenbrod, T., Muñoz-Planillo, R. & Nuñez, G. The inflammasome: a caspase-1–activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol.10, 241–247 (2009). ArticleCASPubMedPubMed Central Google Scholar
Martinon, F., Mayor, A. & Tschopp, J. The inflammasomes: guardians of the body. Annu. Rev. Immunol.27, 229–265 (2009). ArticleCASPubMed Google Scholar
Dinarello, C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol.27, 519–550 (2009). ArticleCASPubMed Google Scholar
Kostura, M.J. et al. Identification of a monocyte specific pre–interleukin 1 β convertase activity. Proc. Natl. Acad. Sci. USA86, 5227–5231 (1989). ArticleCASPubMedPubMed Central Google Scholar
Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science267, 2000–2003 (1995). ArticleCASPubMed Google Scholar
Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell10, 417–426 (2002). ArticleCASPubMed Google Scholar
Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature440, 228–232 (2006). ArticleCASPubMed Google Scholar
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NLRP3 inflammasome. Nature440, 237–241 (2006). ArticleCASPubMed Google Scholar
Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature430, 213–218 (2004). ArticleCASPubMed Google Scholar
Saberi, M. et al. Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab.10, 419–429 (2009). ArticleCASPubMedPubMed Central Google Scholar
Stienstra, R. et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell. Metab.12, 593–605 (2009). Article Google Scholar
Bishop, N.A. & Guarente, L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat. Rev. Genet.8, 835–844 (2007). ArticleCASPubMed Google Scholar
Galgani, J.E. et al. Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate. Diabetes57, 841–845 (2008). ArticleCASPubMed Google Scholar
Kummer, J.A. et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site–specific role in the inflammatory response. J. Histochem. Cytochem.55, 443–452 (2007). ArticleCASPubMed Google Scholar
Joosten, L.A. Inflammatory arthritis in caspase 1 gene–deficient mice: contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1 β. Arthritis Rheum.60, 3651–3662 (2009). ArticleCASPubMedPubMed Central Google Scholar
Virkamäki, A., Ueki, K. & Kahn, C.R. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest.103, 931–943 (1999). ArticlePubMedPubMed Central Google Scholar
Imaeda, A.B. et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nlrp3 inflammasome. J. Clin. Invest.119, 305–314 (2009). CASPubMedPubMed Central Google Scholar
Watanabe, A. et al. Inflammasome-mediated regulation of hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol.296, G1248–G1257 (2009). ArticleCASPubMedPubMed Central Google Scholar
Khan, T. et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol.29, 1575–1591 (2009). ArticleCASPubMed Google Scholar
Håversen, L., Danielsson, K.N., Fogelstrand, L. & Wiklund, O. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis202, 382–393 (2009). ArticlePubMed Google Scholar
Prieur, X., Roszer, T. & Ricote, M. Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome. Biochim. Biophys. Acta1801, 327–337 (2010). ArticleCASPubMed Google Scholar
Shah, C. et al. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J. Biol. Chem.283, 13538–13548 (2008). ArticleCASPubMedPubMed Central Google Scholar
Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med.15, 930–939 (2009). ArticleCASPubMedPubMed Central Google Scholar
Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med.15, 914–920 (2009). ArticleCASPubMed Google Scholar
Yang, H. et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol.185, 1836–1845 (2010). ArticleCASPubMed Google Scholar
Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature464, 1357–1361 (2010). ArticleCASPubMedPubMed Central Google Scholar
Li, H., Ambade, A. & Re, F. Cutting edge: Necrosis activates the NLRP3 inflammasome. J. Immunol.183, 1528–1532 (2009). ArticleCASPubMed Google Scholar
Halberg, N. et al. Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell. Biol.29, 4467–4483 (2009). ArticleCASPubMedPubMed Central Google Scholar
Strissel, K.J. et al. Adipocyte death, adipose tissue remodeling and obesity complications. Diabetes56, 2910–2918 (2007). ArticleCASPubMed Google Scholar
Strissel, K.J. et al. T-cell recruitment and TH1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity18, 1918–1925 (2010). ArticleCASPubMed Google Scholar
Duffaut, C. et al. Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators. Arterioscler. Thromb. Vasc. Biol.29, 1608–1614 (2009). ArticleCASPubMed Google Scholar
Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol.11, 136–140 (2010). ArticleCASPubMed Google Scholar
Dominguez, H. et al. Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J. Vasc. Res.42, 517–525 (2005). ArticleCASPubMed Google Scholar