Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs (original) (raw)

• Hüsemann, Y. et al. Systemic spread is an early step in breast cancer. Cancer Cell 13, 58–68 (2008).
  Article Google Scholar
• Cameron, M.D. et al. Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 60, 2541–2546 (2000).
  CAS PubMed Google Scholar
• Psaila, B. & Lyden, D. The metastatic niche: adapting the foreign soil. Nat. Rev. Cancer 9, 285–293 (2009).
  Article CAS Google Scholar
• Hynes, R.O. The extracellular matrix: not just pretty fibrils. Science 326, 1216–1219 (2009).
  Article CAS Google Scholar
• Barkan, D., Green, J.E. & Chambers, A.F. Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur. J. Cancer 46, 1181–1188 (2010).
  Article CAS Google Scholar
• Anan, K. et al. Disparities in the survival improvement of recurrent breast cancer. Breast Cancer 17, 48–55 (2010).
  Article Google Scholar
• Minn, A.J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518–524 (2005).
  Article CAS Google Scholar
• Tavazoie, S.F. et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147–152 (2008).
  Article CAS Google Scholar
• Gupta, G.P. et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446, 765–770 (2007).
  Article CAS Google Scholar
• Kim, M.Y. et al. Tumor self-seeding by circulating cancer cells. Cell 139, 1315–1326 (2009).
  Article Google Scholar
• Kii, I. et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J. Biol. Chem. 285, 2028–2039 (2010).
  Article CAS Google Scholar
• Orend, G. & Chiquet-Ehrismann, R. Tenascin-C induced signaling in cancer. Cancer Lett. 244, 143–163 (2006).
  Article CAS Google Scholar
• von Holst, A. Tenascin C in stem cell niches: redundant, permissive or instructive? Cells Tissues Organs 188, 170–177 (2008).
  Article CAS Google Scholar
• Artavanis-Tsakonas, S., Rand, M.D. & Lake, R.J. Notch signaling: cell fate control and signal integration in development. Science 284, 770–776 (1999).
  Article CAS Google Scholar
• Logan, C.Y. & Nusse, R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004).
  Article CAS Google Scholar
• Hermann, P.C. et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1, 313–323 (2007).
  Article CAS Google Scholar
• Joyce, J.A. & Pollard, J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239–252 (2009).
  Article CAS Google Scholar
• Deryugina, E.I. & Bourdon, M.A. Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin. J. Cell Sci. 109, 643–652 (1996).
  CAS PubMed Google Scholar
• Ishihara, A., Yoshida, T., Tamaki, H. & Sakakura, T. Tenascin expression in cancer cells and stroma of human breast cancer and its prognostic significance. Clin. Cancer Res. 1, 1035–1041 (1995).
  CAS PubMed Google Scholar
• Tumbar, T. et al. Defining the epithelial stem cell niche in skin. Science 303, 359–363 (2004).
  Article CAS Google Scholar
• Garcion, E., Halilagic, A., Faissner, A. & ffrench-Constant, C. Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development 131, 3423–3432 (2004).
  Article CAS Google Scholar
• Dontu, G. et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17, 1253–1270 (2003).
  Article CAS Google Scholar
• Ponti, D. et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 65, 5506–5511 (2005).
  Article CAS Google Scholar
• Chambers, I. et al. Nanog safeguards pluripotency and mediates germline development. Nature 450, 1230–1234 (2007).
  Article CAS Google Scholar
• Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379–391 (1998).
  Article CAS Google Scholar
• Adewumi, O. et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat. Biotechnol. 25, 803–816 (2007).
  Article CAS Google Scholar
• Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663–676 (2006).
  Article CAS Google Scholar
• Okano, H. et al. Function of RNA-binding protein Musashi-1 in stem cells. Exp. Cell Res. 306, 349–356 (2005).
  Article CAS Google Scholar
• Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003–1007 (2007).
  Article CAS Google Scholar
• Kouros-Mehr, H., Slorach, E.M., Sternlicht, M.D. & Werb, Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127, 1041–1055 (2006).
  Article CAS Google Scholar
• Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. & Clarke, M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).
  Article CAS Google Scholar
• Fillmore, C.M. & Kuperwasser, C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 10, R25 (2008).
  Article Google Scholar
• Imai, T. et al. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol. Cell. Biol. 21, 3888–3900 (2001).
  Article CAS Google Scholar
• Bouras, T. et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 3, 429–441 (2008).
  Article CAS Google Scholar
• Lim, E. et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 15, 907–913 (2009).
  Article CAS Google Scholar
• Molyneux, G. et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7, 403–417 (2010).
  Article CAS Google Scholar
• Wagner, K.U. & Rui, H. Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. J. Mammary Gland Biol. Neoplasia 13, 93–103 (2008).
  Article Google Scholar
• Chammas, R., Taverna, D., Cella, N., Santos, C. & Hynes, N.E. Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation. J. Cell Sci. 107, 1031–1040 (1994).
  CAS PubMed Google Scholar
• Sandberg, E.M. & Sayeski, P.P. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J. Biol. Chem. 279, 34547–34552 (2004).
  Article CAS Google Scholar
• Müller, J., Sperl, B., Reindl, W., Kiessling, A. & Berg, T. Discovery of chromone-based inhibitors of the transcription factor STAT5. ChemBioChem 9, 723–727 (2008).
  Article Google Scholar
• Ruiz, C. et al. Growth promoting signaling by tenascin-C. Cancer Res. 64, 7377–7385 (2004).
  Article CAS Google Scholar
• Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537–549 (2003).
  Article CAS Google Scholar
• Bos, P.D. et al. Genes that mediate breast cancer metastasis to the brain. Nature 459, 1005–1009 (2009).
  Article CAS Google Scholar
• Eilon, T. & Barash, I. Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5. BMC Genomics 10, 231 (2009).
  Article Google Scholar
• Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545–15550 (2005).
  Article CAS Google Scholar
• Ioachim, E. et al. Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur. J. Cancer 38, 2362–2370 (2002).
  Article CAS Google Scholar
• Casali, A. & Batlle, E. Intestinal stem cells in mammals and Drosophila. Cell Stem Cell 4, 124–127 (2009).
  Article CAS Google Scholar
• Lin, S.Y. et al. β-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. USA 97, 4262–4266 (2000).
  Article CAS Google Scholar
• Farnie, G. et al. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J. Natl. Cancer Inst. 99, 616–627 (2007).
  Article CAS Google Scholar
• Wang, X.Y. et al. Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival. Mol. Cancer 9, 221 (2010).
  Article Google Scholar
• Reedijk, M. et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 65, 8530–8537 (2005).
  Article CAS Google Scholar
• Pece, S. et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J. Cell Biol. 167, 215–221 (2004).
  Article CAS Google Scholar
• Cotarla, I. et al. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int. J. Cancer 108, 665–671 (2004).
  Article CAS Google Scholar
• Nevalainen, M.T. et al. Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J. Clin. Oncol. 22, 2053–2060 (2004).
  Article CAS Google Scholar
• Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T. & Aizawa, S. Mice develop normally without tenascin. Genes Dev. 6, 1821–1831 (1992).
  Article CAS Google Scholar
• Mackie, E.J. & Tucker, R.P. The tenascin-C knockout revisited. J. Cell Sci. 112, 3847–3853 (1999).
  CAS PubMed Google Scholar
• Gomis, R.R., Alarcon, C., Nadal, C., Van Poznak, C. & Massague, J. C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 10, 203–214 (2006).
  Article CAS Google Scholar
• Smid, M. et al. Subtypes of breast cancer show preferential site of relapse. Cancer Res. 68, 3108–3114 (2008).
  Article CAS Google Scholar
• Zhang, X.H. et al. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 16, 67–78 (2009).
  Article CAS Google Scholar