The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine (original) (raw)

• Goldstein, J.L. Creation and revelation: two different routes to advancement in the biomedical sciences. Nat. Med. 13, 1151–1154 (2007).
  Article CAS Google Scholar
• Collaboration Research Group for Qinghaosu. A new sesquiterpene lactone—qinghaosu [in Chinese]. Kexue Tongbao 3, 142 (1977).
• Liu, J.M. et al. Structure and reaction of qinghaosu [in Chinese]. Acta Chimi. Sin. 37, 129–143 (1979).
  CAS Google Scholar
• Collaboration research group for Qinghaosu. Studies on new anti-malarial drug qinghaosu [in Chinese]. Yaoxue Tongbao 14, 49–53 (1979).
• Collaboration research group for Qinghaosu. Antimalarial studies on qinghaosu [in Chinese]. Chin. Med. J. 92, 811–816 (1979).
• Tu, Y.Y. The awarded Chinese invention: antimalarial drug qinghaosu [in Chinese]. Rev. World Invent. 4, 26 (1981).
  Google Scholar
• Tu, Y.Y. et al. Studies on the constituents of Artemisia annua L [in Chinese]. Yao Xue Xue Bao 16, 366–370 (1981).
  CAS PubMed Google Scholar
• Tu, Y.Y., Ni, M.Y., Zhong, Y.R. & Li, L.N. Studies on the constituents of Artemisia annua L. and derivatives of artemisinin [in Chinese]. Zhongguo Zhong Yao Za Zhi 6, 31 (1981).
  CAS Google Scholar
• Tu, Y.Y. et al. Studies on the constituents of Artemisia annua L. (II). Planta Med. 44, 143–145 (1982).
  Article CAS Google Scholar
• Collaboration Research Group for Qinghaosu. Chemical studies on qinghaosu. J. Tradit. Chin. Med. 2, 3–8 (1982).
• Xiao, Y.Q. & Tu, Y.Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore [in Chinese]. Yao Xue Xue Bao 19, 909–913 (1984).
  CAS PubMed Google Scholar
• Tu, Y.Y., Yin, J.P., Ji, L., Huang, M.M. & Liang, X.T. Studies on the constituents of Artemisia annua L. (III) [in Chinese]. Chin. Tradit. Herbal Drugs 16, 200–201 (1985).
  Google Scholar
• Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia apiacea Hance [in Chinese]. Chin. Tradit. Herbal Drugs 6, 2–3 (1985).
  Google Scholar
• Tu, Y.Y., Zhu, Q.C. & Shen, X. Studies on the constituents of Young Artemisia annua L [in Chinese]. Zhongguo Zhong Yao Za Zhi 10, 419–420 (1985).
  CAS Google Scholar
• Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia gmelinii Web.exstechm [in Chinese]. Chin. Bull. Bot. 3, 34–37 (1985).
  Google Scholar
• Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia argyi Levl et vant [in Chinese]. Zhongguo Zhong Yao Za Zhi. 10, 31–32 (1985).
  CAS Google Scholar
• Xiao, Y.Q. & Tu, Y.Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore [in Chinese]. Acta Bot. Sin. 28, 307–310 (1986).
  CAS Google Scholar
• Tu, Y.Y. Study on authentic species of Chinese herbal drug winghao [in Chinese]. Bull. Chin. Mater. Med. 12, 2–5 (1987).
  Google Scholar
• Yin, J.P. & Tu, Y.Y. Studies on the constituents of Artemisia eriopoda Bunge [in Chinese]. Chin. Tradit. Herbal Drugs 20, 149–150 (1989).
  CAS Google Scholar
• Gu, Y.C. & Tu, Y.Y. Studies on chemical constituents of Artemisia japonica Thunb [in Chinese]. Chin. Tradit. Herbal Drugs 24, 122–124 (1993).
  CAS Google Scholar
• Klayman, D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049–1055 (1985).
  Article CAS Google Scholar
• Sun, X.Z. et al. Experimental study on the immunosuppressive effects of qinghaosu and its derivatives [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 11, 37–38 (1993).
  Google Scholar
• Yang, S.X., Xie, S.S., Ma, D., Long, Z.Z. & Tu, Y.Y. Immunologic enhancement and reconstitution by qinghaosu and its derivatives [in Chinese]. Chin. Bull. Pharm 9, 61–63 (1992).
  Google Scholar
• Chen, P.H., Tu, Y.Y., Wang, F.Y., Li, F.W. & Yang, L. Effect of dihydroqinghaosu on the development of Plasmodium yoelii in Anopheles stephensi [in Chinese]. Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 16, 421–424 (1998).
  CAS Google Scholar
• Huang, L. et al. Studies on the antipyretic and anti-inflammatory effects of Artemisia annua L [in Chinese]. Zhongguo Zhong Yao Za Zhi 18, 44–48 (1993).
  CAS PubMed Google Scholar
• Tu, Y.Y. The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu. Chin. Med. J. 112, 976–977 (1999).
  CAS PubMed Google Scholar
• Xu, L.M., Chen, X.R. & Tu, Y.Y. Effect of hydroartemisinin on lupus BXSB mice [in Chinese]. Chin. J. Dermatovenerol. Integr. Tradit. West. Med. 1, 19–20 (2002).
  Google Scholar
• Dong, Y.J. et al. Effect of dihydro-qinghaosu on auto-antibody production, TNFa secretion and pathologic change of lupus nephritis in BXSB mice [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 23, 676–679 (2003).
  PubMed Google Scholar
• Dong, Y.J. et al. The effects of DQHS on the pathologic changes in BXSB mice lupus nephritis and the effect mechanism [in Chinese]. Chin. Pharmacol. Bull. 19, 1125–1128 (2003).
  CAS Google Scholar
• Tu, Y.Y. The development of the antimalarial drugs with new type of chemical structure—qinghaosu and dihydroqinghaosu. Southeast Asian J. Trop. Med. Public Health 35, 250–251 (2004).
  CAS PubMed Google Scholar
• Yang, L., Huang, M.M., Zhang, D. & Tu, Y.Y. Determination of scopoletin in qinghao by HPLC [in Chinese]. Chin. J. Exp. Tradit. Med. Formulae 12, 10–11 (2006).
  CAS Google Scholar
• Li, W.D., Dong, Y.J., Tu, Y.Y. & Lin, Z.B. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation. Int. Immunopharmacol. 6, 1243–1250 (2006).
  Article CAS Google Scholar
• Zhang, D., Yang, L., Yang, L.X., Huang, M.M. & Tu, Y.Y. Determination of artemisinin, arteannuin B and artemisinic acid in Artemisia annua by HPLC-UV-ELSD [in Chinese]. Yao Xue Xue Bao 42, 978–981 (2007).
  CAS PubMed Google Scholar
• Qinghao Ji Qinghaosulei Yaowu (Artemisia annua L., Artemisinin and its Derivatives) [in Chinese] (ed. Tu, Y.Y.) (Publisher of Chemical Industry, Beijing, 2009).
• Chen, G.Q. et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood 89, 3345–3353 (1997).
  CAS PubMed Google Scholar
• Zhang, X.W. et al. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 328, 240–243 (2010).
  Article CAS Google Scholar
• Tang, X.C. & Han, Y.F. Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb. CNS Drug Rev. 5, 281–300 (1999).
  Article CAS Google Scholar
• Chen, K.J. et al. XS0601 reduces the incidence of restenosis: a prospective study of 335 patients undergoing percutaneous coronary intervention in China. Chin. Med. J. 119, 6–13 (2006).
  Article CAS Google Scholar
• Gao, D. et al. The effect of Xuefu Zhuyu decoction on in vitro endothelial progenitor cell tube formation. Chin. J. Integr. Med. 16, 50–53 (2010).
  Article CAS Google Scholar
• Zhao, N. et al. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am. J. Physiol. Heart Circ. Physiol. 298, H1166–H11176 (2010).
  Article CAS Google Scholar
• Xu, X.S. et al. The antioxidant Cerebralcare Granule attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. Shock 32, 201–209 (2009).
  Article CAS Google Scholar
• Sun, K. et al. Cerebralcare Granule, a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia–reperfusion. J. Ethnopharmacol. 130, 398–406 (2010).
  Article Google Scholar
• Han, J.Y. et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol. Ther. 117, 280–295 (2008).
  Article CAS Google Scholar
• Liao, F. et al. Biomechanopharmacology: a new borderline discipline. Trends Pharmacol. Sci. 27, 287–289 (2006).
  Article CAS Google Scholar
• You, Y. et al. Joint preventive effects of swimming and Shenlian extract on rat atherosclerosis. Clin. Hemorheol. Microcirc. 47, 187–198 (2011).
  PubMed Google Scholar
• Xie, L.X. et al. The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells. Clin. Hemorheol. Microcirc. 44, 245–258 (2010).
  CAS PubMed Google Scholar