Nutrient sensor links obesity with diabetes risk (original) (raw)

Nature Medicine volume 10, pages 1049–1050 (2004) Cite this article

Overeating can lead to the development of insulin resistance and diabetes. A component of the mTOR nutrient signaling pathway now bridges the mechanistic gap between obesity and insulin resistance.

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Figure 1: mTOR and S6 kinase 1 may link nutrient excess with both obesity and insulin resistance.

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Authors and Affiliations

  1. Research Division, Joslin Diabetes Center, Boston, 02215, Massachusetts, USA
    Mary-Elizabeth Patti
  2. Harvard Medical School, Boston, 02215, Massachusetts, USA
    Mary-Elizabeth Patti
  3. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, 02215, Massachusetts, USA
    Barbara B Kahn
  4. Harvard Medical School, Boston, 02215, Massachusetts, USA
    Barbara B Kahn

Authors

  1. Mary-Elizabeth Patti
  2. Barbara B Kahn

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Patti, ME., Kahn, B. Nutrient sensor links obesity with diabetes risk.Nat Med 10, 1049–1050 (2004). https://doi.org/10.1038/nm1004-1049

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