DNA–based immunization by in vivo transfection of dendritic cells (original) (raw)

References

  1. Doherty, P.C., Knowles, B.B. & Wettstein, P.J. Immunological surveillance of tumours in the context of major histocompatability restriction of T-cell function. Adv. Cancer Res. 42, 1–65 (1984).
    Article CAS PubMed Google Scholar
  2. Yewdell, J.W. & Bennink, J.R. Cell biology of antigen processing and presentation to MHC class I molecule restricted T-lymphocytes. Adv. Immunol. 52, 1–42 (1992).
    Article CAS PubMed Google Scholar
  3. Tang, D.C., DeVit, M. & Johnston, S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 356, 152–154 (1992).
    Article CAS PubMed Google Scholar
  4. Ulmer, J.B. et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745–1749 (1992).
    Article Google Scholar
  5. Williams, R.S. et al. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc. Natl. Acad. Sci. USA 88, 2726–2730 (1991).
    Article CAS PubMed PubMed Central Google Scholar
  6. Fynan, E.F. et al. DNA vaccines: Protective immunization by parenteral, mucosal, and gene gun inoculation. Proc. Natl. Acad. Sci. USA 90, 11478–11482 (1993).
    Article CAS PubMed PubMed Central Google Scholar
  7. Donnelly, J.J. et al. Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus. Nature Med. 1, 583–587 (1995).
    Article CAS PubMed Google Scholar
  8. Conroy, R.M. et al. A carcinoembryonic antigen polynucleotide vaccine has in vivo anti-tumour activity. Gene Ther. 2, 59–62 (1995).
    Google Scholar
  9. Krishnan, S., Haensler, J. & Meulien, P. Paving the way towards DNA vaccines. Nature Med. 1, 521–522 (1995).
    Article CAS PubMed Google Scholar
  10. Pardoll, D.M. & Beckerleg, A.M. Exposing the immunology of naked DNA vaccines. Immunity 3, 165–169 (1995).
    Article CAS PubMed Google Scholar
  11. Kovacsovics-Bankowski, M. & Rock, K.L. A phagosome to cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267, 243–246 (1995).
    Article CAS PubMed Google Scholar
  12. Falo, L.D. Jr., Kovacsovics-Bankowski, M., Thompson, K. & Rock, K.L. Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity. Nature Med. 1, 649–653 (1995).
    Article CAS PubMed Google Scholar
  13. Suto, R. & Sirvastava, P.K. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269, 1585–1588 (1995).
    Article CAS PubMed Google Scholar
  14. Wolff, J.A. et al. Direct gene transfer into mouse muscle in vivo. Science 247, 1465–1468 (1990).
    Article CAS PubMed Google Scholar
  15. Eisenbraun, M.D., Fuller, D.H. & Haynes, J.R. Examination of parameters effecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization. DNA Cell Biol. 12, 791–797 (1993).
    Article CAS PubMed Google Scholar
  16. Yang, N.-S. & Sun, W.H. Gene gun and other non-viral approaches for cancer gene therapy. Nature Med. 1, 481–483 (1995).
    Article CAS PubMed Google Scholar
  17. Fidler, I.J., Gersten, D.M. & Budmen, M.B. Characteristics in vivo and in vitro of tumour cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity Cancer Res. 36, 3160–3165 (1976).
    CAS PubMed Google Scholar
  18. Pan, Z.K., Ikonomidis, G., Lazenby, A., Pardoll, D. & Paterson, Y. A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours. Nature Med. 1, 471–477 (1995).
    Article CAS PubMed Google Scholar
  19. Zhou, F., Rouse, B.T. & Huang, L. Prolonged survival of thymoma bearing mice after vaccination with a soluble protein antigen entrapped in liposomes: A model study. Cancer Res. 52, 6287–6291 (1992).
    CAS PubMed Google Scholar
  20. Huang, A.Y.C. et al. Role of bone marrow derived cells in presenting MHC class I restricted tumour antigens. Science 264, 961–965 (1994).
    Article CAS PubMed Google Scholar
  21. Moore, M.W., Carbone, F.R. & Bevan, M.J. Introduction of soluble proteins into the class I pathway of antigen processing and presentation. Cell 54, 777–785 (1988).
    Article CAS PubMed Google Scholar
  22. Celluzzi, C.M., Mayordomo, J.I., Storkus, W.J., Lotze, M.T. & Falo, L.D. Jr. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med. 183, 283–287 (1996).
    Article CAS PubMed Google Scholar
  23. Van Wilsem, E.J.G., Breve, J., Kleijmeer, M. & Kraal, G. Langerhans cells in skin draining lymph nodes: Phenotype and kinetics of migration. J. Invest. Dermatol. 103, 217–220 (1994).
    Article CAS PubMed Google Scholar
  24. Macatonia, S.E., Knight, S.C., Edwards, A.J., Griffiths, S. & Fryer, P. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate: Functional and morphological studies. J. Exp. Med. 166, 1654–1667 (1987).
    Article CAS PubMed Google Scholar
  25. Conroy, R.M. et al. Selected strategies to augment polynucleotide immunization. Gene Ther. 3, 67–74 (1996).
    Google Scholar
  26. Ciernik, F.I., Brezofsky, J.A. & Carbone, D.P. Induction of cytotoxic T-lymphocytes and antitumor immunity with DNA vaccines expressing single T-cell epitopes. J. Immunol 156, 2369–2375 (1996).
    CAS PubMed Google Scholar
  27. Irvine, K.R., Rao, J.B., Rosenberg, S.A. & Restifo, N.P. Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J. Immunol. 156, 238–245 (1996).
    CAS PubMed Google Scholar
  28. Matsuno, K., Ezaki, T., Kudo, S. & Uehara, Y. A life stage of a particle-laden rat dendritic cell in vivo: Their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J. Exp. Med. 183, 1865–1878 (1996).
    Article CAS PubMed Google Scholar
  29. Huang, Y.C.A., Bruce, A.T., Pardoll, D.M. & Levitsky, H.I. In vivo cross-priming of MHC class I restricted antigens requires the TAP transporter. Immunity 4, 349–355 (1996).
    Article CAS PubMed Google Scholar
  30. Porgador, A. & Gilboa, E. Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J. Exp. Med. 182, 255–258 (1995).
    Article CAS PubMed Google Scholar
  31. Porgador, A. & Gilboa, E. Induction of antitumor immunity using bone marrow generated dendritic cells. J. Immunol. 156, 2918–2926 (1996).
    CAS PubMed Google Scholar
  32. Mayordomo, J.I. et al. Bone marrow-derived dendritic cells pulsed with synthetic tumor peptides elicit protective and therapeutic antitumor immunity. Nature Med. 1, 1297–1304 (1995).
    Article CAS PubMed Google Scholar
  33. Hsu, F.J. et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med. 2, 52–58 (1996).
    Article CAS PubMed Google Scholar
  34. Alijagic, S. et al. Dendritic cells generated from peripheral blood transfected with human tyrosinase induce specific T cell activation. Eur. J. Immunol. 25, 3100–3107 (1995).
    Article CAS PubMed Google Scholar

Download references