Calmodulin kinase II inhibition protects against structural heart disease (original) (raw)

• Jessup, M. & Brozena, S. Heart failure. N. Engl. J. Med. 348, 2007–2018 (2003).
  Article Google Scholar
• Doughty, R.N., Whalley, G.A., Gamble, G., MacMahon, S. & Sharpe, N. Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. Australia-New Zealand Heart Failure Research Collaborative Group. J. Am. Coll. Cardiol. 29, 1060–1066 (1997).
  Article CAS Google Scholar
• Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 353, 2001–2007 (1999).
• Chu, G. et al. A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists. J. Biol. Chem. 275, 38938–38943 (2000).
  Article CAS Google Scholar
• Zhu, W.Z. et al. Linkage of beta(1)-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J. Clin. Invest. 111, 617–625 (2003).
  Article CAS Google Scholar
• Hoch, B., Meyer, R., Hetzer, R., Krause, E.G. & Karczewski, P. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ. Res. 84, 713–721 (1999).
  Article CAS Google Scholar
• Zhang, T. et al. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92, 912–919 (2003).
  Article CAS Google Scholar
• Maier, L.S. et al. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ. Res. 92, 904–911 (2003).
  Article CAS Google Scholar
• Gwathmey, J.K. et al. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ. Res. 61, 70–76 (1987).
  Article CAS Google Scholar
• Gomez, A.M. et al. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276, 800–806 (1997).
  Article CAS Google Scholar
• Hudmon, A. & Schulman, H. Structure/function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem. J. 364, 593–611 (2002).
  Article CAS Google Scholar
• Braun, A.P. & Schulman, H. A non-selective cation current activated via the multi-functional Ca(2+)-calmodulin-dependent protein kinase in human epithelial cells. J. Physiol. 488, 37–55 (1995).
  Article CAS Google Scholar
• Huang, W., Aramburu, J., Douglas, P.S. & Izumo, S. Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy. Nat. Med. 6, 482–483 (2000).
  Article CAS Google Scholar
• Wu, Y. et al. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation 106, 1288–1293 (2002).
  Article CAS Google Scholar
• Benedict, C.R. et al. Prognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunction. SOLVD Investigators. Circulation 94, 690–697 (1996).
  Article CAS Google Scholar
• Vinogradova, T.M. et al. Sinoatrial node pacemaker activity requires Ca2+/calmodulin- dependent protein kinase II activation. Circ. Res. 87, 760–767 (2000).
  Article CAS Google Scholar
• Bauman, A.L. & Scott, J.D. Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo. Nat. Cell Biol. 4, E203–E206 (2002).
  Article CAS Google Scholar
• Hagemann, D. et al. Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J. Biol. Chem. 275, 2532–22536 (2000).
  Article Google Scholar
• Drago, G.A. & Colyer, J. Discrimination between two sites of phosphorylation on adjacent amino acids by phosphorylation site-specific antibodies to phospholamban. J. Biol. Chem. 269, 25073–25077 (1994).
  CAS Google Scholar
• Benjamin, I.J. et al. Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ. Res. 65, 657–670 (1989).
  Article CAS Google Scholar
• Ramirez, M.T., Zhao, X.L., Schulman, H. & Brown, J.H. The nuclear deltaB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes. J. Biol. Chem. 272, 31203–31208 (1997).
  Article CAS Google Scholar
• Kudej, R.K. et al. Effects of chronic beta-adrenergic receptor stimulation in mice. J. Mol. Cell Cardiol. 29, 2735–2746 (1997).
  Article CAS Google Scholar
• Dzhura, I., Wu, Y., Colbran, R.J., Balser, J.R. & Anderson, M.E. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat. Cell Biol. 2, 173–177 (2000).
  Article CAS Google Scholar
• Yue, D.T., Herzig, S. & Marban, E. Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes. Proc. Nat. Acad. Sci. USA 87, 753–757 (1990).
  Article CAS Google Scholar
• Currie, S., Loughrey, C.M., Craig, M.A. & Smith, G.L. Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochem. J. 377, 357–366 (2004).
  Article CAS Google Scholar
• Marx, S.O. et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101, 365–376 (2000).
  Article CAS Google Scholar
• Cannon, W.P. & de la Paz, D. Emotional stimulation of adrenal secretion. Am. J. Physiol. 28, 64–70 (1911).
  Article CAS Google Scholar
• Fabiato, A. & Fabiato, F. Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells. J. Physiol. 249, 469–495 (1975).
  Article CAS Google Scholar
• Wehrens, X.H., Lehnart, S.E., Reiken, S.R. & Marks, A.R. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ. Res. 94, e61–e70 (2004).
  Article CAS Google Scholar
• Rodriguez, P., Bhogal, M.S. & Colyer, J. Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A. J. Biol. Chem. 278, 38593–38600 (2003).
  Article CAS Google Scholar
• Cheng, H., Lederer, W.J. & Cannell, M.B. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262, 740–744 (1993).
  Article CAS Google Scholar
• Sah, R., Ramirez, R.J., Kaprielian, R. & Backx, P.H. Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. J. Physiol. 533, 201–214 (2001).
  Article CAS Google Scholar
• Alseikhan, B.A., DeMaria, C.D., Colecraft, H.M. & Yue, D.T. Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation. Proc. Natl. Acad. Sci. USA 99, 17185–17190 (2002).
  Article CAS Google Scholar
• Chao, S.H., Suzuki, Y., Zysk, J.R. & Cheung, W.Y. Activation of calmodulin by various metal cations as a function of ionic radius. Mol. Pharmacol. 26, 75–82 (1984).
  CAS Google Scholar
• Gao, T. et al. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 19, 185–196 (1997).
  Article CAS Google Scholar
• Anderson, M.E., Braun, A.P., Schulman, H. & Premack, B.A. Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes. Circ. Res. 75, 854–861 (1994).
  Article CAS Google Scholar
• Xiao, R.P., Cheng, H., Lederer, W.J., Suzuki, T. & Lakatta, E.G. Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx. Proc. Natl. Acad. Sci. USA 91, 9659–9663 (1994).
  Article CAS Google Scholar
• Yuan, W. & Bers, D.M. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am. J. Physiol. 267, H982–H993 (1994).
  CAS Google Scholar
• Cohen, P. Protein kinases--the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1, 309–315 (2002).
  Article CAS Google Scholar
• Bers, D.M. Cardiac excitation-contraction coupling. Nature 415, 198–205 (2002).
  Article CAS Google Scholar
• Patberg, K.W. et al. Cardiac memory is associated with decreased levels of the transcriptional factor CREB modulated by angiotensin II and calcium. Circ. Res. 93, 472–478 (2003).
  Article CAS Google Scholar
• Benitah, J.P. & Vassort, G. Aldosterone upregulates Ca(2+) current in adult rat cardio-myocytes. Circ. Res. 85, 1139–1145 (1999).
  Article CAS Google Scholar
• Chu, L. et al. Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium. Circ. Res. 92, 1024–1032 (2003).
  Article CAS Google Scholar
• Muth, J.N., Bodi, I., Lewis, W., Varadi, G. & Schwartz, A. A Ca(2+)-dependent transgenic model of cardiac hypertrophy: A role for protein kinase Calpha. Circulation 103, 140–147 (2001).
  Article CAS Google Scholar
• Pan, L., Gurevich, E.V. & Gurevich, V.V. The nature of the arrestin x receptor complex determines the ultimate fate of the internalized receptor. J. Biol. Chem. 278, 11623–11632 (2003).
  Article CAS Google Scholar
• Wu, Y., Colbran, R.J. & Anderson, M.E. Calmodulin kinase is a molecular switch for cardiac excitation - contraction coupling. Proc. Natl. Acad. Sci. USA 98, 2877–2881 (2001).
  Article CAS Google Scholar
• Hadley, R.W. & Lederer, W.J. Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes. J. Gen. Physiol. 98, 265–285 (1991).
  Article CAS Google Scholar
• Rottman, J.N. et al. Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice. J. Am. Soc. Echocardiogr. 16, 1150–1157 (2003).
  Article Google Scholar
• Ichihara, S. et al. Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation 106, 2244–2249 (2002).
  Article CAS Google Scholar
• Choi, B.R. & Salama, G. Optical mapping of atrioventricular node reveals a conduction barrier between atrial and nodal cells. Am. J. Physiol. 274, H829–H845 (1998).
  CAS Google Scholar