Natural regulatory T cells control the development of atherosclerosis in mice (original) (raw)

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Acknowledgements

This work was supported by Inserm and by Assistance Publique-Hôpitaux de Paris as a Contrat d'Interface (to Z.M.). Inserm U689 and the Center for Molecular Medicine at Karolinska Institute are partners of the European Vascular Genomics Network, a Network of Excellence granted by the European Commission (contract LSHM-CT-2003-503254). We are indebted to B. Levacher and J. Vilard for technical assistance in Q-PCR experiments, to F. Djelti for her technical support and to J. Nemeth for her assistance in the reading of pathological specimens. We are also indebted to L. Chatenoud for providing us with the 2G7 TGF-β–specific antibody and for discussions. H.A.-O. was supported by Fédération Française de Cardiologie.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 689, Centre de Recherche Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, Paris, 75010, France
    Hafid Ait-Oufella, Stéphane Potteaux, Joffrey Zoll, Régine Merval, Bruno Esposito, Alain Tedgui & Ziad Mallat
  2. Centre National de la Recherche Scientifique, Unité mixte de Recherche 7087, Groupe Hospitalier Pitié-Salpêtrière, Paris, 75013, France
    Benoît L Salomon, José L Cohen, Sylvain Fisson & David Klatzmann
  3. Department of Medicine, Center for Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, SE-17176, Sweden
    Anna-Karin L Robertson & Göran K Hansson
  4. Inserm U589, Institut L. Bugnard, Toulouse, 31432, Cedex 4, France
    Pierre Gourdy
  5. Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 330 Cedar Street, New Haven, 06520, Connecticut, USA
    Richard A Flavell

Authors

  1. Hafid Ait-Oufella
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  2. Benoît L Salomon
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  3. Stéphane Potteaux
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  4. Anna-Karin L Robertson
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  5. Pierre Gourdy
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  6. Joffrey Zoll
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  7. Régine Merval
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  8. Bruno Esposito
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  9. José L Cohen
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  10. Sylvain Fisson
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  11. Richard A Flavell
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  12. Göran K Hansson
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  13. David Klatzmann
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  14. Alain Tedgui
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  15. Ziad Mallat
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Corresponding author

Correspondence toZiad Mallat.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

Transferred CD4+CD25+ regulatory T cells survive in vivo, retain Foxp3 expression and inhibit proliferation of CD25 deficient cells through Tgf-β and cell-cell contact. (PDF 80 kb)

Supplementary Fig. 2

Transferred CD4+CD25+ regulatory T cells retained high levels of Tgf-β mRNA expression. (PDF 40 kb)

Supplementary Fig. 3

CD4+CD25+ regulatory T cells (Treg) induce a switch toward an anti-inflammatory cytokine profile. (PDF 38 kb)

Supplementary Methods (PDF 42 kb)

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Ait-Oufella, H., Salomon, B., Potteaux, S. et al. Natural regulatory T cells control the development of atherosclerosis in mice.Nat Med 12, 178–180 (2006). https://doi.org/10.1038/nm1343

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