Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo (original) (raw)

• Peto, J. Cancer epidemiology in the last century and the next decade. Nature 411, 390–395 (2001).
  Article CAS PubMed Google Scholar
• Ponder, B.A. Cancer genetics. Nature 411, 336–341 (2001).
  Article CAS PubMed Google Scholar
• Lowe, S.W. & Lin, A.W. Apoptosis in cancer. Carcinogenesis 21, 485–495 (2000).
  Article CAS PubMed Google Scholar
• Nicholson, D.W. From bench to clinic with apoptosis-based therapeutic agents. Nature 407, 810–816 (2000).
  Article CAS PubMed Google Scholar
• Hengartner, M.O. The biochemistry of apoptosis. Nature 407, 770–777 (2000).
  CAS PubMed Google Scholar
• Herr, I. & Debatin, K.M. Cellular stress response and apoptosis in cancer therapy. Blood 98, 2603–2614 (2001).
  Article CAS PubMed Google Scholar
• Mow, B.M., Blajeski, A.L., Chandra, J. & Kaufmann, S.H. Apoptosis and the response to anticancer therapy. Curr. Opin. Oncol. 13, 453–462 (2001).
  Article CAS PubMed Google Scholar
• Fulda, S., Susin, S.A., Kroemer, G. & Debatin, K.M. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res. 58, 4453–4460 (1998).
  CAS PubMed Google Scholar
• Fulda, S., Meyer, E., Susin, S.A., Kroemer, G. & Debatin, K.M. Cell type specific activation of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 20, 1063–1075 (2001).
  Article CAS PubMed Google Scholar
• Fulda, S. et al. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 20, 5865–5877 (2001).
  Article CAS PubMed Google Scholar
• Ashkenazi, A. & Dixit, V.M. Death receptors: Signaling and modulation. Science 281, 1305–1308 (1998).
  Article CAS PubMed Google Scholar
• Walczak, H. & Krammer, P.H. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp. Cell Res. 256, 58–66 (2000).
  Article CAS PubMed Google Scholar
• Thornberry, N. & Lazebnik, Y. Caspases: Enemies within. Science 281, 1312–1316 (1998).
  Article CAS PubMed Google Scholar
• Scaffidi, C. et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675–1687 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Kroemer, G. & Reed, J.C. Mitochondrial control of cell death. Nature Med. 6, 513–519 (2000).
  Article CAS PubMed Google Scholar
• Roy, S. & Nicholson, D. Cross-talk in cell death signaling. J. Exp. Med. 192, F21–F25 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Antonsson, B. & Martinou, J.C. The Bcl-2 protein family. Exp. Cell Res. 256, 50–57 (2000).
  Article CAS PubMed Google Scholar
• Goyal, L. Cell death inhibition: Keeping caspases in check. Cell 104, 805–808 (2001).
  Article CAS PubMed Google Scholar
• Deveraux, Q.L. & Reed, J.C. IAP family proteins-suppressors of apoptosis. Genes Dev. 13, 239–252 (1999).
  Article CAS PubMed Google Scholar
• Wagenknecht, B. et al. Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma. Cell Death Differ. 6, 370–376 (1999).
  Article CAS PubMed Google Scholar
• Du, C., Fang, M., Li, Y., Li, L. & Wang, X. Smac, a mitochondrial protein that promotes cytochrome _c_-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33–42 (2000).
  Article CAS PubMed Google Scholar
• Verhagen, A.M. et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102, 43–53 (2000).
  Article CAS PubMed Google Scholar
• Srinivasula, S.M. et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410, 112–116 (2001).
  Article CAS PubMed Google Scholar
• Chai, J. et al. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406, 855–862 (2000).
  Article CAS PubMed Google Scholar
• Green, D. Apoptotic pathways: Paper wraps stone blunts scissors. Cell 102, 1–4 (2000).
  Article CAS PubMed Google Scholar
• Fulda, S., Meyer, E. & Debatin, K.M. Overexpression of Bcl-2 inhibits TRAIL-induced apoptosis. Oncogene 21, 2283–2294 (2002).
  Article CAS PubMed Google Scholar
• Wu, G. et al. Structural basis of IAP recognition by Smac/DIABLO. Nature 408, 1008–1012 (2000).
  Article CAS PubMed Google Scholar
• Roth, W. et al. Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in a thymic mice in the absence of neurotoxicity. Biochem. Biophys. Res. Commun. 265, 479–483 (1999).
  Article CAS PubMed Google Scholar
• Weissert, R. et al. MHC haplotype-dependent regulation of MOG-induced EAE in rats. J. Clin. Invest. 102, 1265–1273 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Walczak, H. et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nature Med. 5, 157–163 (1999).
  Article CAS PubMed Google Scholar
• Chuntharapai, A. et al. Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. J. Immunol. 166, 4891–4898 (2001).
  Article CAS PubMed Google Scholar
• Soengas, M.S. et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409, 207–211 (2001).
  Article CAS PubMed Google Scholar
• Lawrence, D. et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nature Med. 7, 383–385 (2001).
  Article CAS PubMed Google Scholar
• Ashkenazi, A. et al. Safety and anti-tumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155–162 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Nagane, M., Huang, H.J. & Cavenee, W.K. The potential of TRAIL for cancer chemotherapy. Apoptosis 6, 191–197 (2001).
  Article CAS PubMed Google Scholar
• Ichikawa, K. et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nature Med. 7, 954–960 (2001).
  Article CAS PubMed Google Scholar
• Deng, Y., Lin, Y. & Wu, X. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 16, 33–45 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, L., Yu, J., Park, B., Kinzler, K. & Vogelstein, B. Role of BAX in the apoptotic response to anticancer agents. Science 290, 989–992 (2000).
  Article CAS PubMed Google Scholar
• LeBlanc, H. et al. Tumor-cell resistance to death receptor–induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. Nature Med. 8, 274–281 (2002).
  Article CAS PubMed Google Scholar
• Zhang, X.D., Zhang, X.Y., Gray, C.P., Nguyen, T. & Hersey, P. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by Smac/DIABLO release from mitochondria. Cancer Res. 61, 7339–7348 (2001).
  CAS PubMed Google Scholar
• DeAngelis, L.M. Brain tumors. N. Engl. J. Med. 344, 114–122 (2001).
  Article CAS PubMed Google Scholar
• Jeremias, I., Herr, I., Boehler, T. & Debatin, K.M. TRAIL / Apo-2-Ligand induced apoptosis in T-cells. Eur. J. Immunol. 28, 143–152 (1998).
  Article CAS PubMed Google Scholar
• Hanemann, C.O. et al. Improved culture methods to expand Schwann cells with altered growth behaviour from CMT1A patients. Glia 23, 89–98 (1998).
  Article CAS PubMed Google Scholar
• Lindgren, M., Hallbrink, M., Prochiantz, A. & Langel, U. Cell-penetrating peptides. Trends Pharmacol. Sci. 21, 99–103 (2000).
  Article CAS PubMed Google Scholar
• Srinivasula, S.M. et al. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J. Biol. Chem. 275, 36152–36457 (2000).
  Article CAS PubMed Google Scholar