Mechanism of hard-nanomaterial clearance by the liver (original) (raw)

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Acknowledgements

We would to acknowledge the Canadian Institute of Health Research, Natural Sciences and Engineering Research Council, and Collaborative Health Research Program for funding the project. K.M.T. thanks the NSERC Vanier Canada Graduate Scholarship Program and the Surgeon-Scientist Program at the University of Toronto for financial support. S.A.M. thanks the CASL/CIHR Hepatology Fellowship Program and the National CIHR Research Training Program in Hepatitis C for financial support. We would also like to acknowledge M. Peralta and C. Hoculada from the University Health Network Pathology Research Program (Toronto, Canada), D. Holmyard from the Mount Sinai Advanced Bioimaging Centre (Toronto, Canada), F. Xu from the University Health Network Advanced Optical Microscopy Facility (Toronto, Canada), D. White from the Department of Immunology, University of Toronto (Toronto, Ontario), J. Manual, J. Feld and V. Cherepanov from the Toronto Centre for Liver Disease (Toronto, Canada), J. Krieger from the SPARC Biocentre at the Hospital for Sick Children (Toronto, Canada) and A. Black from the Department of Anatomy, National University of Ireland, Galway (Galway, Ireland) for their assistance.

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Author notes

1. Kim M. Tsoi and Sonya A. MacParland: These authors contributed equally to this work.

Authors and Affiliations

1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada
   Kim M. Tsoi, Ben Ouyang, Edward A. Sykes, Anton Zilman & Warren C. W. Chan
2. Division of Orthopaedic Surgery, University of Toronto, 149 College Street, Toronto, Ontario M5T 1P5, Canada
   Kim M. Tsoi
3. Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
   Sonya A. MacParland, Saleh M. Fadel & Mario A. Ostrowski
4. Multi Organ Transplant Program, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
   Xue-Zhong Ma, Vinzent N. Spetzler, Juan Echeverri, Nicolas Goldaracena, Johann M. Kaths, John B. Conneely, Markus Selzner & Ian D. McGilvray
5. Department of Orthopaedic Surgery, Duke University, Duke University Medical Center, Room 2888, 200 Trent Drive, Durham, North Carolina 27710, USA
   Benjamin A. Alman
6. Department of Pathology, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
   Oyedele A. Adeyi
7. Department of Physics, University of Toronto, 60 St. George Street, Toronto, Ontario M5S 1A7, Canada
   Anton Zilman
8. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 230, Toronto, Ontario M5S 3E1, Canada
   Warren C. W. Chan
9. Department of Chemical Engineering, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada
   Warren C. W. Chan
10. Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada
    Warren C. W. Chan
11. Department of Material Science and Engineering, University of Toronto, 160 College Street, Room 450, Toronto, Ontario M5S 3E1, Canada
    Warren C. W. Chan

Authors

1. Kim M. Tsoi
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2. Sonya A. MacParland
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3. Xue-Zhong Ma
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4. Vinzent N. Spetzler
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5. Juan Echeverri
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6. Ben Ouyang
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7. Saleh M. Fadel
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8. Edward A. Sykes
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9. Nicolas Goldaracena
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10. Johann M. Kaths
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11. John B. Conneely
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12. Benjamin A. Alman
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13. Markus Selzner
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14. Mario A. Ostrowski
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15. Oyedele A. Adeyi
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16. Anton Zilman
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17. Ian D. McGilvray
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18. Warren C. W. Chan
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Contributions

K.M.T., S.A.M., J.B.C., I.D.M. and W.C.W.C. conceived the idea. K.M.T., S.A.M., O.A.A., I.D.M. and W.C.W.C. analysed the data. K.M.T. and S.A.M. conducted the experiments with assistance from X.-Z.M., V.N.S., J.E., B.O., S.M.F., E.A.S., N.G. and J.M.K. A.Z. performed the mathematical modelling. B.A.A., M.S. and M.A.O. supervised some of the work.

Corresponding authors

Correspondence toIan D. McGilvray or Warren C. W. Chan.

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Competing interests

The authors declare no competing financial interests.

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Tsoi, K., MacParland, S., Ma, XZ. et al. Mechanism of hard-nanomaterial clearance by the liver.Nature Mater 15, 1212–1221 (2016). https://doi.org/10.1038/nmat4718

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• Received: 30 July 2015
• Accepted: 04 July 2016
• Published: 15 August 2016
• Issue Date: November 2016
• DOI: https://doi.org/10.1038/nmat4718