Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse (original) (raw)
Meaney, M.J. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci.24, 1161–1192 (2001). ArticleCAS Google Scholar
Higley, J.D., Hasert, M.F., Suomi, S.J. & Linnoila, M. Nonhuman primate model of alcohol abuse: effects of early experience, personality and stress on alcohol consumption. Proc. Natl. Acad. Sci. USA88, 7261–7265 (1991). ArticleCAS Google Scholar
Liu, D. et al. Maternal care, hippocampal glucocorticoid receptors and hypothalamic-pituitary-adrenal responses to stress. Science277, 1659–1662 (1997). ArticleCAS Google Scholar
Weaver, I.C. et al. Epigenetic programming by maternal behavior. Nat. Neurosci.7, 847–854 (2004). ArticleCAS Google Scholar
de Kloet, E.R., Joels, M. & Holsboer, F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci.6, 463–475 (2005). ArticleCAS Google Scholar
Boyle, M.P. et al. Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc. Natl. Acad. Sci. USA102, 473–478 (2005). ArticleCAS Google Scholar
Ridder, S. et al. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci.25, 6243–6250 (2005). ArticleCAS Google Scholar
Reichardt, H.M., Tronche, F., Bauer, A. & Schutz, G. Molecular genetic analysis of glucocorticoid signaling using the Cre/loxP system. Biol. Chem.381, 961–964 (2000). ArticleCAS Google Scholar
De Bellis, M.D. et al. Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls. J. Clin. Endocrinol. Metab.78, 249–255 (1994). CASPubMed Google Scholar
Pruessner, J.C., Champagne, F., Meaney, M.J. & Dagher, A. Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. J. Neurosci.24, 2825–2831 (2004). ArticleCAS Google Scholar
Heim, C. & Nemeroff, C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol. Psychiatry49, 1023–1039 (2001). ArticleCAS Google Scholar
Webster, M.J., Knable, M.B., O'Grady, J., Orthmann, J. & Weickert, C.S. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol. Psychiatry7, 985–994 (2002). ArticleCAS Google Scholar
Schatzberg, A.F., Rothschild, A.J., Langlais, P.J., Bird, E.D. & Cole, J.O. A corticosteroid/dopamine hypothesis for psychotic depression and related states. J. Psychiatr. Res.19, 57–64 (1985). ArticleCAS Google Scholar
Isometsa, E.T. et al. Suicide in major depression. Am. J. Psychiatry151, 530–536 (1994). ArticleCAS Google Scholar
Widom, C.S., DuMont, K. & Czaja, S.J. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch. Gen. Psychiatry64, 49–56 (2007). Article Google Scholar
Fergusson, D.M., Horwood, L.J. & Lynskey, M.T. Childhood sexual abuse and psychiatric disorder in young adulthood. II. Psychiatric outcomes of childhood sexual abuse. J. Am. Acad. Child Adolesc. Psychiatry35, 1365–1374 (1996). ArticleCAS Google Scholar
Weaver, I.C. et al. The transcription factor nerve growth factor–inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes. J. Neurosci.27, 1756–1768 (2007). ArticleCAS Google Scholar
McCormick, J.A. et al. 5′-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol. Endocrinol.14, 506–517 (2000). CASPubMed Google Scholar
Turner, J.D. & Muller, C.P. Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification and tissue distribution of multiple new human exon 1. J. Mol. Endocrinol.35, 283–292 (2005). ArticleCAS Google Scholar
Breslin, M.B., Geng, C.D. & Vedeckis, W.V. Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol. Endocrinol.15, 1381–1395 (2001). ArticleCAS Google Scholar
Encio, I.J. & Detera-Wadleigh, S.D. The genomic structure of the human glucocorticoid receptor. J. Biol. Chem.266, 7182–7188 (1991). CASPubMed Google Scholar
Weaver, I.C. et al. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J. Neurosci.25, 11045–11054 (2005). ArticleCAS Google Scholar
Razin, A. CpG methylation, chromatin structure and gene silencing a three-way connection. EMBO J.17, 4905–4908 (1998). ArticleCAS Google Scholar
Bird, A. Molecular biology. Methylation talk between histones and DNA. Science294, 2113–2115 (2001). ArticleCAS Google Scholar
Clark, S.J., Harrison, J., Paul, C.L. & Frommer, M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res.22, 2990–2997 (1994). ArticleCAS Google Scholar
Yamada, K. et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl. Acad. Sci. USA104, 2815–2820 (2007). ArticleCAS Google Scholar
Cervoni, N. & Szyf, M. Demethylase activity is directed by histone acetylation. J. Biol. Chem.276, 40778–40787 (2001). ArticleCAS Google Scholar
Crosby, S.D., Puetz, J.J., Simburger, K.S., Fahrner, T.J. & Milbrandt, J. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element–binding protein family. Mol. Cell. Biol.11, 3835–3841 (1991). ArticleCAS Google Scholar
Plotsky, P.M. et al. Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology30, 2192–2204 (2005). ArticleCAS Google Scholar
Oberlander, T.F. et al. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics3, 97–106 (2008). Article Google Scholar
Fleming, A.S., O'Day, D.H. & Kraemer, G.W. Neurobiology of mother-infant interactions: experience and central nervous system plasticity across development and generations. Neurosci. Biobehav. Rev.23, 673–685 (1999). ArticleCAS Google Scholar
Pilowsky, D.J. et al. Children of depressed mothers 1 year after the initiation of maternal treatment: findings from the STAR*D child study. Am. J. Psychiatry165, 1136–1147 (2008). Article Google Scholar
Holsboer, F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology23, 477–501 (2000). ArticleCAS Google Scholar
Neigh, G.N. & Nemeroff, C.B. Reduced glucocorticoid receptors: consequence or cause of depression? Trends Endocrinol. Metab.17, 124–125 (2006). ArticleCAS Google Scholar
Abdolmaleky, H.M. et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum. Mol. Genet.15, 3132–3145 (2006). ArticleCAS Google Scholar
Grayson, D.R. et al. Reelin promoter hypermethylation in schizophrenia. Proc. Natl. Acad. Sci. USA102, 9341–9346 (2005). ArticleCAS Google Scholar
Siegmund, K.D. et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS ONE2, e895 (2007). Article Google Scholar
Ernst, C. et al. The effects of pH on DNA methylation state: in vitro and postmortem brain studies. J. Neurosci. Methods174, 123–125 (2008). ArticleCAS Google Scholar
Vythilingam, M. et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am. J. Psychiatry159, 2072–2080 (2002). Article Google Scholar
Seguin, M. et al. Life trajectories and burden of adversity: mapping the developmental profiles of suicide mortality. Psychol. Med.37, 1575–1583 (2007). Article Google Scholar
Brezo, J. et al. Natural history of suicidal behaviors in a population-based sample of young adults. Psychol. Med.37, 1563–1574 (2007). PubMed Google Scholar
Kaufman, J., Plotsky, P.M., Nemeroff, C.B. & Charney, D.S. Effects of early adverse experiences on brain structure and function: clinical implications. Biol. Psychiatry48, 778–790 (2000). ArticleCAS Google Scholar
Teicher, M.H., Andersen, S.L., Polcari, A., Anderson, C.M. & Navalta, C.P. Developmental neurobiology of childhood stress and trauma. Psychiatr. Clin. North Am.25, 397–426 (2002). Article Google Scholar
Fisher, P.A., Gunnar, M.R., Chamberlain, P. & Reid, J.B. Preventive intervention for maltreated preschool children: impact on children's behavior, neuroendocrine activity and foster parent functioning. J. Am. Acad. Child Adolesc. Psychiatry39, 1356–1364 (2000). ArticleCAS Google Scholar
Brezo, J. et al. Predicting suicide attempts in young adults with histories of childhood abuse. Br. J. Psychiatry193, 134–139 (2008). Article Google Scholar
Sequeira, A. & Turecki, G. Genome wide gene expression studies in mood disorders. OMICS10, 444–454 (2006). ArticleCAS Google Scholar
Spitzer, R.L., Williams, J.B., Gibbon, M. & First, M.B. The Structured Clinical Interview for DSM-III-R (SCID). I: history, rationale and description. Arch. Gen. Psychiatry49, 624–629 (1992). ArticleCAS Google Scholar
Dumais, A. et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am. J. Psychiatry162, 2116–2124 (2005). ArticleCAS Google Scholar
Bifulco, A., Brown, G.W. & Harris, T.O. Childhood Experience of Care and Abuse (CECA): a retrospective interview measure. J. Child Psychol. Psychiatry35, 1419–1435 (1994). ArticleCAS Google Scholar
Frommer, M. et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA89, 1827–1831 (1992). ArticleCAS Google Scholar