BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets (original) (raw)
Hsieh, J. & Gage, F.H. Chromatin remodeling in neural development and plasticity. Curr. Opin. Cell Biol.17, 664–671 (2005). CASPubMed Google Scholar
Yoo, A.S. & Crabtree, G.R. ATP-dependent chromatin remodeling in neural development. Curr. Opin. Neurobiol.19, 120–126 (2009). CASPubMedPubMed Central Google Scholar
Hirabayashi, Y. & Gotoh, Y. Epigenetic control of neural precursor cell fate during development. Nat. Rev. Neurosci.11, 377–388 (2010). CASPubMed Google Scholar
Bertrand, N., Castro, D.S. & Guillemot, F. Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci.3, 517–530 (2002). CASPubMed Google Scholar
Kageyama, R., Ohtsuka, T., Shimojo, H. & Imayoshi, I. Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nat. Neurosci.11, 1247–1251 (2008). CASPubMed Google Scholar
Louvi, A. & Artavanis-Tsakonas, S. Notch signaling in vertebrate neural development. Nat. Rev. Neurosci.7, 93–102 (2006). CASPubMed Google Scholar
Pierfelice, T., Alberi, L. & Gaiano, N. Notch in the vertebrate nervous system: an old dog with new tricks. Neuron69, 840–855 (2011). CASPubMed Google Scholar
Kopan, R. & Ilagan, M.X. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell137, 216–233 (2009). CASPubMedPubMed Central Google Scholar
Ohtsuka, T., Sakamoto, M., Guillemot, F. & Kageyama, R. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J. Biol. Chem.276, 30467–30474 (2001). CASPubMed Google Scholar
Shimojo, H., Ohtsuka, T. & Kageyama, R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron58, 52–64 (2008). CASPubMed Google Scholar
Kawaguchi, D., Yoshimatsu, T., Hozumi, K. & Gotoh, Y. Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon. Development135, 3849–3858 (2008). CASPubMed Google Scholar
Borggrefe, T. & Liefke, R. Fine-tuning of the intracellular canonical Notch signaling pathway. Cell Cycle11, 264–276 (2012). CASPubMed Google Scholar
Mizutani, K., Yoon, K., Dang, L., Tokunaga, A. & Gaiano, N. Differential Notch signaling distinguishes neural stem cells from intermediate progenitors. Nature449, 351–355 (2007). CASPubMed Google Scholar
Redmond, L., Oh, S.R., Hicks, C., Weinmaster, G. & Ghosh, A. Nuclear Notch1 signaling and the regulation of dendritic development. Nat. Neurosci.3, 30–40 (2000). CASPubMed Google Scholar
Sestan, N., Artavanis-Tsakonas, S. & Rakic, P. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science286, 741–746 (1999). CASPubMed Google Scholar
Hashimoto-Torii, K. et al. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron60, 273–284 (2008). CASPubMedPubMed Central Google Scholar
Kriegstein, A. & Alvarez-Buylla, A. The glial nature of embryonic and adult neural stem cells. Annu. Rev. Neurosci.32, 149–184 (2009). CASPubMedPubMed Central Google Scholar
Noctor, S.C., Martinez-Cerdeno, V., Ivic, L. & Kriegstein, A.R. Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nat. Neurosci.7, 136–144 (2004). CASPubMed Google Scholar
Miyata, T. et al. Asymmetric production of surface-dividing and non–surface-dividing cortical progenitor cells. Development131, 3133–3145 (2004). CASPubMed Google Scholar
Malatesta, P., Hartfuss, E. & Gotz, M. Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development127, 5253–5263 (2000). CASPubMed Google Scholar
Tiberi, L., Vanderhaeghen, P. & van den Ameele, J. Cortical neurogenesis and morphogens: diversity of cues, sources and functions. Curr. Opin. Cell Biol.24, 269–276 (2012). CASPubMed Google Scholar
Götz, M. & Huttner, W.B. The cell biology of neurogenesis. Nat. Rev. Mol. Cell Biol.6, 777–788 (2005). PubMed Google Scholar
Okano, H. & Temple, S. Cell types to order: temporal specification of CNS stem cells. Curr. Opin. Neurobiol.19, 112–119 (2009). CASPubMed Google Scholar
Gaspard, N. et al. An intrinsic mechanism of corticogenesis from embryonic stem cells. Nature455, 351–357 (2008). CASPubMed Google Scholar
Gaspard, N. & Vanderhaeghen, P. Mechanisms of neural specification from embryonic stem cells. Curr. Opin. Neurobiol.20, 37–43 (2010). CASPubMed Google Scholar
Chang, C.C., Ye, B.H., Chaganti, R.S. & Dalla-Favera, R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA93, 6947–6952 (1996). CASPubMedPubMed Central Google Scholar
Ye, B.H. et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science262, 747–750 (1993). CASPubMed Google Scholar
Iacovino, M. et al. Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells. Stem Cells29, 1580–1588 (2011). CASPubMedPubMed Central Google Scholar
van den Ameele, J. et al. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep.13, 355–362 (2012). CASPubMedPubMed Central Google Scholar
Ye, B.H. et al. The Bcl6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet.16, 161–170 (1997). CASPubMed Google Scholar
Phan, R.T. & Dalla-Favera, R. The Bcl6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature432, 635–639 (2004). CASPubMed Google Scholar
Otaki, J.M., Hatano, M., Matayoshi, R., Tokuhisa, T. & Yamamoto, H. The proto-oncogene Bcl6 promotes survival of olfactory sensory neurons. Dev. Neurobiol.70, 424–435 (2010). CASPubMed Google Scholar
Zhang, S.J. et al. Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. Neuron53, 549–562 (2007). CASPubMed Google Scholar
Bedogni, F. et al. Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc. Natl. Acad. Sci. USA107, 13129–13134 (2010). CASPubMedPubMed Central Google Scholar
Funatsu, N., Inoue, T. & Nakamura, S. Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes. Cereb. Cortex14, 1031–1044 (2004). PubMed Google Scholar
Leamey, C.A. et al. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Cereb. Cortex18, 53–66 (2008). PubMed Google Scholar
Ong, C.T. et al. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J. Biol. Chem.281, 5106–5119 (2006). CASPubMed Google Scholar
Sakano, D. et al. BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning. Dev. Cell18, 450–462 (2010). CASPubMedPubMed Central Google Scholar
Hisahara, S. et al. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc. Natl. Acad. Sci. USA105, 15599–15604 (2008). CASPubMedPubMed Central Google Scholar
Mulligan, P. et al. A SIRT1-LSD1 co-repressor complex regulates Notch target gene expression and development. Mol. Cell42, 689–699 (2011). CASPubMedPubMed Central Google Scholar
Guarani, V. et al. Acetylation-dependent regulation of endothelial Notch signaling by the SIRT1 deacetylase. Nature473, 234–238 (2011). CASPubMedPubMed Central Google Scholar
Min, S.W. et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron67, 953–966 (2010). CASPubMedPubMed Central Google Scholar
Bray, S. & Bernard, F. Notch targets and their regulation. Curr. Top. Dev. Biol.92, 253–275 (2010). CASPubMed Google Scholar
Hoeck, J.D. et al. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat. Neurosci.13, 1365–1372 (2010). CASPubMed Google Scholar
Sabharwal, P., Lee, C., Park, S., Rao, M. & Sockanathan, S. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron71, 1058–1070 (2011). CASPubMedPubMed Central Google Scholar
Endo, K. et al. Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat. Neurosci.15, 224–233 (2012). CAS Google Scholar
Prozorovski, T. et al. Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat. Cell Biol.10, 385–394 (2008). CASPubMed Google Scholar
Gao, J. et al. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature466, 1105–1109 (2010). CASPubMedPubMed Central Google Scholar
Donmez, G., Wang, D., Cohen, D.E. & Guarente, L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell142, 320–332 (2010). CASPubMedPubMed Central Google Scholar
Gaspard, N. et al. Generation of cortical neurons from mouse embryonic stem cells. Nat. Protoc.4, 1454–1463 (2009). CASPubMed Google Scholar
Heng, J.I. et al. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature455, 114–118 (2008). CASPubMed Google Scholar
Rustighi, A. et al. The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat. Cell Biol.11, 133–142 (2009). CASPubMed Google Scholar
Takeda, N. et al. Bcl6 is a transcriptional repressor for the IL-18 gene. J. Immunol.171, 426–431 (2003). CASPubMed Google Scholar
Saito, T. & Nakatsuji, N. Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev. Biol.240, 237–246 (2001). CASPubMed Google Scholar
Dufour, A. et al. Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes. Neuron39, 453–465 (2003). CASPubMed Google Scholar
Depaepe, V. et al. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature435, 1244–1250 (2005). CASPubMed Google Scholar