Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse (original) (raw)

References

  1. Everitt, B.J. & Wolf, M.E. Psychomotor stimulant addiction: a neural systems perspective. J. Neurosci. 22, 3312–3320 (2002).
    Article CAS Google Scholar
  2. Koob, G. & LeMoal, M. Drug addiction, dysregulation of reward and allostasis. Neuropsychopharmacology 24, 97–129 (2001).
    Article CAS Google Scholar
  3. Shalev, U., Grimm, J.W. & Shaham, Y. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54, 1–42 (2002).
    Article CAS Google Scholar
  4. McFarland, K. & Kalivas, P.W. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci. 21, 8655–8663 (2001).
    Article CAS Google Scholar
  5. Goldstein, R.A. & Volkow, N.D. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am. J. Psychiatry 159, 1642–1652 (2002).
    Article Google Scholar
  6. Park, W.K. et al. Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J. Neurosci. 22, 2916–2925 (2002).
    Article CAS Google Scholar
  7. Cornish, J. & Kalivas, P. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J. Neurosci. 20, RC89(1–5) (2000).
    Article Google Scholar
  8. Di Ciano, P. & Everitt, B.J. Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior. Neuropsychopharmacology 25, 341–360 (2001).
    Article CAS Google Scholar
  9. Pierce, R.C., Bell, K., Duffy, P. & Kalivas, P.W. Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. J. Neurosci. 16, 1550–1560 (1996).
    Article CAS Google Scholar
  10. Hotsenpiller, G., Giorgetti, M. & Wolf, M.E. Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure. Eur. J. Neurosci. 14, 1843–1855 (2001).
    Article CAS Google Scholar
  11. McFarland, K., Lapish, C.C. & Kalivas, P.W. Glutamate, not dopamine, in the accumbens core mediates cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci. 23, 3531–3537 (2003).
    Article CAS Google Scholar
  12. Baker, D.A., Xi, Z.X., Shen, H., Swanson, C.J. & Kalivas, P.W. The origin and neuronal function of in vivo nonsynaptic glutamate. J. Neurosci. 22, 9134–9141 (2002).
    Article CAS Google Scholar
  13. Timmerman, W. & Westerink, B.H. Brain microdialysis of GABA and glutamate: what does it signify? Synapse 27, 242–261 (1997).
    Article CAS Google Scholar
  14. Sato, H., Tamba, M., Ishii, T. & Bannai, S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J. Biol. Chem. 274, 11455–11458 (1999).
    Article CAS Google Scholar
  15. Shih, A.Y. & Murphy, T.H. xCt cystine transporter expression in HEK293 cells: pharmacology and localization. Biochem. Biophys. Res. Commun. 282, 1132–1137 (2001).
    Article CAS Google Scholar
  16. Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L. & Coyle, J.T. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2, 1547–1558 (1989).
    Article CAS Google Scholar
  17. Sasaki, H. et al. Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J. Biol. Chem. 277, 44765–44771 (2002).
    Article CAS Google Scholar
  18. Sato, H. et al. Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain. J. Neurosci. 22, 8028–8033 (2002).
    Article CAS Google Scholar
  19. Warr, O., Takahashi, M. & Attwell, D. Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange. J. Physiol. 514, 783–793 (1999).
    Article CAS Google Scholar
  20. Ye, Z.-C., Rothstein, J.D. & Sontheimer, H. Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J. Neurosci. 19, 10767–10777 (1999).
    Article CAS Google Scholar
  21. Meister, A. Methods for the selective modification of glutathione metabolism and study of glutathione transport. Methods Enzymol. 113, 571–585 (1985).
    Article CAS Google Scholar
  22. Griffith, O.W. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic. Biol. Med. 27, 922–935 (1999).
    Article CAS Google Scholar
  23. Reid, M.S., Hsu, K.J. & Berger, S.P. Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine. Synapse 27, 95–105 (1997).
    Article CAS Google Scholar
  24. Smith, J.A., Mo, Q., Guo, H., Kunko, P.M. & Robinson, S.E. Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens. Brain Res. 683, 264–269 (1995).
    Article CAS Google Scholar
  25. Kamencic, H., Griebel, R.W., Lyon, A.W., Patterson, P.G. & Juurlink, H.J. Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function. FASEB J. 15, 243–250 (2001).
    Article CAS Google Scholar
  26. Cornish, J.L., Duffy, P. & Kalivas, P.W. A role of nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience 93, 1359–1368 (1999).
    Article CAS Google Scholar
  27. Wolf, M.E. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog. Neurobiol. 54, 679–720 (1998).
    Article CAS Google Scholar
  28. Vanderschuren, L.J. & Kalivas, P.W. Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology (Berl.) 151, 99–120 (2000).
    Article CAS Google Scholar
  29. Keys, A.S., Mark, G.P., Emre, N. & Meshul, C.K. Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse 30, 393–401 (1998).
    Article CAS Google Scholar
  30. Knickelbein, R.G., Seres, T., Lam, G., Johnston, R.B.J. & Warashaw, J.B. Characterization of multiple cysteine and cystine transporters in rat alveolar type II cells. Am. J. Physiol. 273, 1147–1155 (1997).
    Google Scholar
  31. Cotgreave, I.A. & Schuppe-Koistinen, I. A role for gamma-glutamyl transpeptidase in the transport of cystine into human endothelial cells: relationship to intracellular glutathione. Biochim. Biophys. Acta 1222, 375–382 (1994).
    Article CAS Google Scholar
  32. Gochenauer, G.E. & Robinson, M.B. Dibutyryl-cAMP (dbcAMP) up-regulates astrocytic chloride-dependent L-[3H]glutamate transport and expression of both system xc(-) subunits. J. Neurochem. 78, 276–286 (2001).
    Article CAS Google Scholar
  33. Sato, H. et al. Induction of cystine transport via system x-c and maintenance of intracellular glutathione levels in pancreatic acinar and islet cell lines. Biochim. Biophys. Acta 1414, 85–94 (1998).
    Article CAS Google Scholar
  34. O'Donnell, P. & Grace, A.A. Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hi_P_ocampal gating of prefrontal cortical input. J. Neurosci. 15, 3622–3639 (1995).
    Article CAS Google Scholar
  35. Anwyl, R. Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res. Rev. 29, 83–120 (1999).
    Article CAS Google Scholar
  36. Manzoni, O., Michel, J.-M. & Bockaert, J. Metabotropic glutamate receptors in the rat nucleus accumbens. Eur. J. Neurosci. 9, 1514–1523 (1997).
    Article CAS Google Scholar
  37. Thomas, M.J., Beurrier, C., Bonci, A. & Malenka, R.C. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat. Neurosci. 4, 1217–1223 (2001).
    Article CAS Google Scholar
  38. White, F., Hu, X., Zhang, X. & Wolf, M. Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system. J. Pharmacol. Exp. Ther. 273, 445–454 (1995).
    CAS PubMed Google Scholar
  39. Sutton, M.A. et al. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature 421, 70–75 (2003).
    Article CAS Google Scholar
  40. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic, New York, 1986).
  41. Pfeiffer, C.M., Huff, D.L. & Gunter, E.W. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin. Chem. 45, 290–292 (1999).
    CAS PubMed Google Scholar

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