Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size (original) (raw)

• Duncan, R. The dawning era of polymer therapeutics. Nature Rev. Drug Discov. 2, 347–360 (2003).
  Article CAS Google Scholar
• Ferrari, M. Cancer nanotechnology: opportunities and challenges. Nature Rev. Cancer. 5, 161–171 (2005).
  Article CAS Google Scholar
• Torchilin, V. P. Recent advances with liposomes as pharmaceutical carriers. Nature Rev. Drug Discov. 4, 145–160 (2005).
  Article CAS Google Scholar
• Davis, M. E., Chen, Z. & Shin, D. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nature Rev. Drug Discov. 7, 771–782 (2008).
  Article CAS Google Scholar
• Kataoka, K., Harada, A. & Nagasaki, Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug Deliv. Rev. 47, 113–131 (2001).
  Article CAS Google Scholar
• Nishiyama, N. & Kataoka, K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther. 112, 630–648 (2006).
  Article CAS Google Scholar
• Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumouritropic accumulation of proteins and the antitumour agent SMANCS. Cancer Res. 46, 6387–6392 (1986).
  CAS Google Scholar
• Nishiyama, N. et al. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumours in mice. Cancer Res. 63, 8977–8983 (2003).
  CAS Google Scholar
• Bae, Y. et al. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug. Chem. 16, 122–130 (2005).
  Article CAS Google Scholar
• Cabral, H., Nishiyama, N. & Kataoka, K. Optimization of (1,2-diamino-cyclohexane) platinum(II)-loaded polymeric micelles directed to improved tumour targeting and enhanced antitumour activity. J. Control. Release 121, 146–155 (2007).
  Article CAS Google Scholar
• Maruyama, K., Ishida, O., Takizawa, T. & Moribe, K. Possibility of active targeting to tumor tissue with liposome. Adv. Drug Deliv. Rev. 40, 89–102 (1999).
  Article CAS Google Scholar
• Lammers, T. et al. Image-guided and passively tumor-targeted polymeric nanomedicines for radiochemotherapy. Br. J. Cancer 99, 900–910 (2008).
  Article CAS Google Scholar
• Matsumura, Y. & Kataoka, K. Preclinical and clinical studies of anticancer agent-incorporating polymer micelles. Cancer Sci. 100, 572–579 (2009).
  Article CAS Google Scholar
• Matsumura, Y. Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect. Adv. Drug Deliv. Rev. 63, 184–192 (2011).
  Article CAS Google Scholar
• Working, P. K. et al. Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in stealth liposomes (DOXIL). J. Liposome Res. 4, 667–687 (1994).
  Article Google Scholar
• Northfelt, D. W. et al. Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial. J. Clin. Oncol. 16, 2445–2451 (1998).
  Article CAS Google Scholar
• Gradishar, W. J. et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J. Clin. Oncol. 23, 7794–7803 (2005).
  Article CAS Google Scholar
• Uster, P. S., Working, P. K. & Vaage, J. Pegylated liposomal doxorubicin (DOXIL(R), CAELYX(R)) distribution in tumour models observed with confocal laser scanning microscopy. Int. J. Pharm. 162, 77–86 (1998).
  Article CAS Google Scholar
• Unezaki, S. et al. Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy. Int. J. Pharm. 144, 11–17 (1996).
  Article CAS Google Scholar
• Kano, M. R. et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumours by inhibition of TGF-β signaling. Proc. Natl Acad. Sci. USA 104, 3460–3465 (2007).
  Article CAS Google Scholar
• Dreher, M. et al. Tumour vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl Cancer Inst. 98, 330–343 (2006).
  Article Google Scholar
• Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C. & Chan, W. C. W. Mediating tumour targeting efficiency of nanoparticles through design. Nano Lett. 9, 1909–1915 (2009).
  Article CAS Google Scholar
• Aliabadi, H. M. & Lavasanifar, A. Polymeric micelles for drug delivery. Exp. Opin. Drug. Deliv. 3, 139–162 (2006).
  Article CAS Google Scholar
• Matsumura, Y. et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br. J. Cancer 91, 1775–1781 (2004).
  Article CAS Google Scholar
• Plummer, R. et al. A phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. Br. J. Cancer 104, 593–598 (2011).
  Article CAS Google Scholar
• Cabral, H., Nishiyama, N., Okazaki, S., Kato, Y. & Kataoka, K. Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. J. Control. Release 101, 223–232 (2005).
  Article CAS Google Scholar
• Nishiyama, N. & Kataoka, K. Preparation and characterization of size-controlled polymeric micelle containing _cis_-dichlorodiammineplatinum(II) in the core. J. Control. Release 74, 83–94 (2001).
  Article CAS Google Scholar
• Murakami, M. et al. Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Sci. Transl. Med. 3, 64ra2 (2011).
  Article CAS Google Scholar
• Alexis, F., Pridgen, E., Molnar, L. K. & Farokhzad, O. C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5, 505–515 (2008).
  Article CAS Google Scholar
• Verma, A. et al. Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nature Mater. 7, 588–595 (2008).
  Article CAS Google Scholar
• Kano, M. R. et al. Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-β receptor inhibitor on extravasation of nanoparticles from neovasculature. Cancer Sci. 100, 173–180 (2009).
  Article CAS Google Scholar
• Takahashi, Y. et al. Significance of vessel count, vascular endothelial growth factor, and its receptor (KDR) in intestinal-type gastric cancer. Clin. Cancer Res. 2, 1679–1684 (1996).
  CAS Google Scholar
• Sofuni, A. et al. Differential diagnosis of pancreatic tumours using ultrasound contrast imaging. J. Gastroenterol. 40, 518–525 (2005).
  Article Google Scholar
• Matsumoto, Y. et al. Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Optics Exp. 1, 1209–1216 (2010).
  Article Google Scholar
• Choi, H. S. et al. Renal clearance of quantum dots. Nature Biotechnol. 25, 1165–1170 (2007).
  Article CAS Google Scholar
• Terada, Y. et al. Construction and commissioning of BL37XU at SPring-8. AIP Conf. Proc. 705, 376–379 (2004).
  Article Google Scholar