Chemically induced mouse models of acute and chronic intestinal inflammation (original) (raw)

• Danese, S. & Fiocchi, C. Ulcerative colitis. N. Engl. J. Med. 365, 1713–1725 (2011).
  Article CAS Google Scholar
• Baumgart, D.C. & Sandborn, W.J. Crohn's disease. Lancet 380, 1590–1605 (2012).
  Article Google Scholar
• Neurath, M.F. Cytokines in inflammatory bowel disease. Nat. Rev. Immunol. 14, 329–342 (2014).
  Article CAS Google Scholar
• Wirtz, S. & Neurath, M.F. Mouse models of inflammatory bowel disease. Adv. Drug Deliv. Rev. 59, 1073–1083 (2007).
  Article CAS Google Scholar
• Saleh, M. & Elson, C.O. Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity 34, 293–302 (2011).
  Article CAS Google Scholar
• Strober, W., Fuss, I.J. & Blumberg, R.S. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20, 495–549 (2002).
  Article CAS Google Scholar
• Lopez-Posadas, R. et al. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J. Clin. Invest. 126, 611–626 (2016).
  Article Google Scholar
• Perse, M. & Cerar, A. Dextran sodium sulphate colitis mouse model: traps and tricks. J. Biomed. Biotechnol. 2012, 718617 (2012).
  Article Google Scholar
• Elson, C.O. et al. Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J. Immunol. 157, 2174–2185 (1996).
  CAS PubMed Google Scholar
• Fiorucci, S. et al. Importance of innate immunity and collagen binding integrin α1β1 in TNBS-induced colitis. Immunity 17, 769–780 (2002).
  Article CAS Google Scholar
• Neurath, M.F., Fuss, I., Kelsall, B.L., Stuber, E. & Strober, W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182, 1281–1290 (1995).
  Article CAS Google Scholar
• Dohi, T. et al. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J. Exp. Med. 189, 1169–1180 (1999).
  Article CAS Google Scholar
• Kiesler, P., Fuss, I.J. & Strober, W. Experimental models of inflammatory bowel diseases. Cell. Mol. Gastroenterol. Hepatol. 1, 154–170 (2015).
  Article Google Scholar
• Rieder, F., Zimmermann, E.M., Remzi, F.H. & Sandborn, W.J. Crohn's disease complicated by strictures: a systematic review. Gut 62, 1072–1084 (2013).
  Article CAS Google Scholar
• Fichtner-Feigl, S. et al. Induction of IL-13 triggers TGF-β1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J. Immunol. 178, 5859–5870 (2007).
  Article CAS Google Scholar
• Boirivant, M., Fuss, I.J., Chu, A. & Strober, W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J. Exp. Med. 188, 1929–1939 (1998).
  Article CAS Google Scholar
• Heller, F., Fuss, I.J., Nieuwenhuis, E.E., Blumberg, R.S. & Strober, W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17, 629–638 (2002).
  Article CAS Google Scholar
• Gerlach, K. et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat. Immunol. 15, 676–686 (2014).
  Article CAS Google Scholar
• Olszak, T. et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336, 489–493 (2012).
  Article CAS Google Scholar
• Hoving, J.C. et al. B cells that produce immunoglobulin E mediate colitis in BALB/c mice. Gastroenterology 142, 96–108 (2012).
  Article CAS Google Scholar
• Okayasu, I. et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98, 694–702 (1990).
  Article CAS Google Scholar
• Laroui, H. et al. Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon. PLoS One 7, e32084 (2012).
  Article CAS Google Scholar
• Hernandez-Chirlaque, C. et al. Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis. J. Crohns Colitis 10, 1324–1335 (2016).
  Article Google Scholar
• Hudcovic, T., Stepankova, R., Cebra, J. & Tlaskalova-Hogenova, H. The role of microflora in the development of intestinal inflammation: acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice. Folia Microbiol. 46, 565–572 (2001).
  Article CAS Google Scholar
• Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745–757 (2011).
  Article CAS Google Scholar
• Dieleman, L.A. et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107, 1643–1652 (1994).
  Article CAS Google Scholar
• Krieglstein, C.F. et al. Collagen-binding integrin α1β1 regulates intestinal inflammation in experimental colitis. J. Clin. Invest. 110, 1773–1782 (2002).
  Article CAS Google Scholar
• Dieleman, L.A. et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 114, 385–391 (1998).
  Article CAS Google Scholar
• Rosen, M.J. et al. Mucosal expression of type 2 and type 17 immune response genes distinguishes ulcerative colitis from colon-only Crohn's disease in treatment-naive pediatric patients. Gastroenterology 152, 1345–1357 (2017).
  Article CAS Google Scholar
• Reinisch, W. et al. Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study. Gut 64, 894–900 (2015).
  Article CAS Google Scholar
• Danese, S. et al. Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study. Gut 64, 243–249 (2015).
  Article CAS Google Scholar
• Engelhardt, K.R. & Grimbacher, B. IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Curr. Top. Microbiol. Immunol. 380, 1–18 (2014).
  CAS PubMed Google Scholar
• Kontoyiannis, D., Pasparakis, M., Pizarro, T.T., Cominelli, F. & Kollias, G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387–398 (1999).
  Article CAS Google Scholar
• Pizarro, T.T. et al. SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis. Inflamm. Bowel Dis. 17, 2566–2584 (2011).
  Article Google Scholar
• Wirtz, S., Neufert, C., Weigmann, B. & Neurath, M.F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541–546 (2007).
  Article CAS Google Scholar
• Mahler, M. et al. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 274, G544–G551 (1998).
  CAS PubMed Google Scholar
• Bleich, A. & Fox, J.G. The mammalian microbiome and its importance in laboratory animal research. ILAR J. 56, 153–158 (2015).
  Article CAS Google Scholar
• Laukens, D., Brinkman, B.M., Raes, J., De Vos, M. & Vandenabeele, P. Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design. FEMS Microbiol. Rev. 40, 117–132 (2016).
  Article CAS Google Scholar
• Podolsky, D.K., Gerken, G., Eyking, A. & Cario, E. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 137, 209–220 (2009).
  Article CAS Google Scholar
• Kilkenny, C., Browne, W.J., Cuthill, I.C., Emerson, M. & Altman, D.G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 8, e1000412 (2010).
  Article Google Scholar
• Becker, C. et al. In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy. Gut 54, 950–954 (2005).
  Article CAS Google Scholar
• Vowinkel, T., Kalogeris, T.J., Mori, M., Krieglstein, C.F. & Granger, D.N. Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis. Dig. Dis. Sci. 49, 556–564 (2004).
  Article CAS Google Scholar
• Tseng, J.C. & Kung, A.L. In vivo imaging of inflammatory phagocytes. Chem. Biol. 19, 1199–1209 (2012).
  Article CAS Google Scholar
• Van den Broeck, W., Derore, A. & Simoens, P. Anatomy and nomenclature of murine lymph nodes: descriptive study and nomenclatory standardization in BALB/cAnNCrl mice. J. Immunol. Methods 312, 12–19 (2006).
  Article CAS Google Scholar
• Strober, W. Appendix 3B Trypan blue exclusion test of cell viability. Curr. Protoc. Immunol. http://dx.doi.org/10.1002/0471142735.ima03bs21 (2001).
• Yu, Y.R. et al. A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues. PLoS One 11, e0150606 (2016).
  Article Google Scholar
• Amsen, D., de Visser, K.E. & Town, T. Approaches to determine expression of inflammatory cytokines. Methods Mol. Biol. 511, 107–142 (2009).
  Article CAS Google Scholar
• Moolenbeek, C. & Ruitenberg, E.J. The 'Swiss roll': a simple technique for histological studies of the rodent intestine. Lab. Anim. 15, 57–59 (1981).
  Article CAS Google Scholar
• Cardiff, R.D., Miller, C.H. & Munn, R.J. Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb. Protoc. 2014, 655–658 (2014).
  PubMed Google Scholar
• Wirtz, S., Billmeier, U., McHedlidze, T., Blumberg, R.S. & Neurath, M.F. Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis. Gastroenterology 141, 1875–1886 (2011).
  Article CAS Google Scholar
• Becker, C., Fantini, M.C. & Neurath, M.F. High resolution colonoscopy in live mice. Nat. Protoc. 1, 2900–2904 (2006).
  Article CAS Google Scholar
• Erben, U. et al. A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int. J. Clin. Exp. Pathol. 7, 4557–4576 (2014).
  PubMed PubMed Central Google Scholar
• Pfeiffer, C.J. & Qiu, B.S. Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats. J. Pharm. Pharmacol. 47, 827–832 (1995).
  Article CAS Google Scholar
• Weigmann, B. et al. Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue. Nat. Protoc. 2, 2307–2311 (2007).
  Article CAS Google Scholar
• Edgar, R.C. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat. Methods 10, 996–998 (2013).
  Article CAS Google Scholar
• Huse, S.M. et al. VAMPS: a website for visualization and analysis of microbial population structures. BMC Bioinformatics 15, 41 (2014).
  Article Google Scholar
• Cooper, H.S., Murthy, S.N., Shah, R.S. & Sedergran, D.J. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab. Invest. 69, 238–249 (1993).
  CAS PubMed Google Scholar