Platelets and the immune continuum (original) (raw)

• Bizzozero, G. Sur un nouvel èlèment morphologique du sang chez les mammiferes et son importance dans la thrombose et dans la coagulation. Arch. Ital. Biol. 1, 1–5 (1882).
  Google Scholar
• Gawaz, M. et al. Platelets in inflammation and atherogenesis. J. Clin. Invest. 115, 3378–3384 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Nieswandt, B. et al. Integrins in platelet activation. J. Thromb. Haemost. 7 (Suppl. 1), 206–209 (2009).
  Article CAS PubMed Google Scholar
• Smyth, S. S. et al. Platelet functions beyond hemostasis. J. Thromb. Haemost. 7, 1759–1766 (2009).
  Article CAS PubMed Google Scholar
• Kaushansky, K. Lineage-specific hematopoietic growth factors. N. Engl. J. Med. 354, 2034–2045 (2006).
  Article CAS PubMed Google Scholar
• Italiano, J. E. Jr & Hartwig, J. H. in Platelets 2nd edn (eds Michelson, A. D. & Coller, B. S.) 23–44 (Elsevier, Amsterdam, 2007).
  Book Google Scholar
• Levin, J. in Platelets 2nd edn (eds Michelson, A. D. & Coller, B. S.) 3–22 (Elsevier, Amsterdam, 2007).
  Book Google Scholar
• Hose, J. E., Martin, G. G. & Gerard, A. S. A decapod hemocyte classification scheme integrating morphology, cytochemistry, and function. Biol. Bull. 178, 33–45 (1990).
  Article CAS PubMed Google Scholar
• Götz, P. & Boman, H. G. in Comprehensive Insect Physiology, Biochemistry and Pharmacology (eds Kerkut, G. A. & Gilbert, L. I.) 453–485 (Pergamon, Oxford, 1985).
  Google Scholar
• Thon, J. N. & Italiano, J. E. Jr. Platelet formation. Semin. Hematol. 47, 220–226 (2010).
  CAS Google Scholar
• Patel, S. R. et al. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 106, 4076–4085 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Thon, J. N. et al. Cytoskeletal mechanics of proplatelet maturation and platelet release. J. Cell Biol. 191, 861–874 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Hartwig, J. Mechanisms of actin rearrangements mediating platelet activation. J. Cell Biol. 118, 1421–1442 (1992).
  Article CAS PubMed Google Scholar
• Diacovo, T. G., Puri, K. D., Warnock, R. A., Springer, T. A. & von Andrian, U. H. Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273, 252–255 (1996).
  Article CAS PubMed Google Scholar
• Italiano, J. E. Jr et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released. Blood. 111, 1227–1233 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Sehgal, S. & Storrie, B. Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release. J. Thromb. Haemost. 5, 2009–2016 (2007).
  Article CAS PubMed Google Scholar
• White, G. C. & Rompietti, R. Platelet secretion: indiscriminately spewed forth or highly orchestrated? J. Thromb. Haemost. 5, 2006–2008 (2007).
  Article CAS PubMed Google Scholar
• Wicki, A. N. et al. Isolation and characterization of human blood platelet mRNA and construction of a cDNA library in λgt11. Confirmation of the platelet derivation by identification of GPIb coding mRNA and cloning of a GPIb coding cDNA insert. Thromb. Haemost. 61, 448–453 (1989).
  Article CAS Google Scholar
• Shashkin, P. N., Brown, G. T., Ghosh, A., Marathe, G. K. & McIntyre, T. M. Lipopolysaccharide is a direct agonist for platelet RNA splicing. J. Immunol. 181, 3495–3502 (2008).
  Article CAS Google Scholar
• Lindemann, S. & Gawaz, M. The active platelet: translation and protein synthesis in an anucleate cell. Semin. Thromb. Hemost. 33, 144–150 (2007).
  Article CAS PubMed Google Scholar
• Denis, M. M. et al. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122, 379–391 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Coppinger, J. A. Moderation of the platelet releasate response by aspirin. Blood 109, 4786–4792 (2007).
  Article CAS PubMed Google Scholar
• Mazzucco, L., Borzini, P. & Gope, R. Platelet-derived factors involved in tissue repair — from signal to function. Transfus. Med. Rev. 24, 218–234 (2010).
  Article PubMed Google Scholar
• Assoian, R. K., Komoriya, A., Meyers, C. A., Miller, D. M. & Sporn, M. B. Transforming growth factor-β in human platelets: identification of a major storage site, purification, and characterization. J. Biol. Chem. 258, 7155–7160 (1983).
  Article CAS PubMed Google Scholar
• Andersson, P. O., Stockelberg, D., Jacobsson, S. & Wadenvik, H. A transforming growth factor-β1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura. Ann. Hematol. 79, 507–513 (2000).
  Article CAS PubMed Google Scholar
• Andersson, P. O., Olsson, A. & Wadenvik, H. Reduced transforming growth factor-β1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura. Br. J. Haematol. 116, 862–867 (2002).
  Article CAS PubMed Google Scholar
• Ling, Y., Cao, X., Yu, Z. & Ruan, C. Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome. Eur. J. Haematol. 79, 310–316 (2007).
  Article CAS PubMed Google Scholar
• Liu, B. et al. Abnormality of CD4+CD25+ regulatory T cells in idiopathic thrombocytopenic purpura. Eur. J. Haematol. 78, 139–143 (2007).
  CAS PubMed Google Scholar
• Stasi, R. et al. Analysis of regulatory T cell changes in patients with idiopathic thrombocytopenic purpura receiving B-cell depleting therapy with rituximab. Blood 112, 1147–1150 (2008).
  Article CAS PubMed Google Scholar
• Olsson, B., Ridell, B., Carlsson, L., Jacobsson, S. & Wadenvik, H. Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1. Blood 12, 1078–1084 (2008).
  Article CAS Google Scholar
• Yu, J. et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood 112, 1325–1328 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Grewal, I. S. & Flavell, R. A. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16, 111–135 (1998).
  Article CAS PubMed Google Scholar
• Henn, V. et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391, 591–594 (1998).
  Article CAS PubMed Google Scholar
• Andre, P., Nannizzi-Alaimo, L., Prasad, S. K. & Phillips, D. R. Platelet-derived CD40L: the switch-hitting player of cardiovascular disease. Circulation 106, 896–899 (2002).
  Article PubMed Google Scholar
• Hammwöhner, M. et al. Platelet expression of CD40/CD40 ligand and its relation to inflammatory markers and adhesion molecules in patients with atrial fibrillation. Exp. Biol. Med. 232, 581–589 (2007).
  Google Scholar
• Anand, S. X., Viles-Gonzalez, J. F. & Badimon, J. J. Membrane-associated CD40L and sCD40L in atherothrombotic disease. Thromb. Haemost. 90, 377–384 (2003).
  Article CAS PubMed Google Scholar
• Henn, V., Steinbach, S., Büchner, K., Presek, P. & Kroczek, R. A. The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40. Blood 98, 1047–1054 (2001).
  Article CAS PubMed Google Scholar
• von Hundelshausen, P. & Weber, C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ. Res. 100, 27–40 (2007).
  Article CAS PubMed Google Scholar
• Elzey, B. D. et al. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 19, 9–19 (2003).
  Article CAS PubMed Google Scholar
• Sprague, D. L. et al. Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 111, 5028–5036 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Elzey, B. D. et al. Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood 111, 3684–3691 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Iannacone, M. et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nature Med. 11, 1167–1169 (2005).
  Article CAS PubMed Google Scholar
• Kissel, K. et al. Human platelets target dendritic cell differentiation and production of proinflammatory cytokines. Transfusion 46, 818–827 (2006).
  Article CAS PubMed Google Scholar
• Janeway, C. A. Jr. The immune system evolved to discriminate infectious non-self from non-infectious self. Immunol. Today 13, 11–15 (1992).
  Article CAS PubMed Google Scholar
• Janeway, C. A. Jr & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197–216 (2002).
  Article CAS PubMed Google Scholar
• Scott, T. & Owens, M. D. Thrombocytes respond to lipopolysaccharide through Toll-like receptor-4, and MAP kinase and NF-κB pathways leading to expression of interleukin-6 and cyclooxygenase-2 with production of prostaglandin E2. Mol. Immunol. 45, 1001–1008 (2008).
  Article CAS PubMed Google Scholar
• Kuckleburg, C. J., Tiwari, R. & Czuprynski, C. J. Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species. Thromb. Haemost. 99, 363–372 (2008).
  Article CAS PubMed Google Scholar
• Kuckleburg, C. J., McClenahan, D. J. & Czuprynski, C. J. Platelet activation by Histophilus somni and its lipooligosaccharide induces endothelial cell proinflammatory responses and platelet internalization. Shock 29, 189–196 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Aslam, R., Freedman, J. & Semple, J. W. Murine platelets express Toll-like receptor 2: a potential regulator of innate and adaptive immunity. Platelets 15, 267–269 (2004).
  Google Scholar
• Shiraki, R. et al. Expression of Toll-like receptors on human platelets. Thromb. Res. 113, 379–385 (2004).
  Article CAS PubMed Google Scholar
• Andonegui, G. et al. Platelets express functional Toll-like receptor-4. Blood 106, 2417–2423 (2005).
  Article CAS PubMed Google Scholar
• Cognasse, F. et al. Evidence of Toll-like receptor molecules on human platelets. Immunol. Cell Biol. 88, 196–198 (2005).
  Article CAS Google Scholar
• Aslam, R. et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo. Blood 107, 637–641 (2006).
  Article CAS PubMed Google Scholar
• Semple, J. W., Aslam, R., Kim, M., Speck, E. R. & Freedman, J. Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG opsonized platelets. Blood 109, 4803–4805 (2007).
  Article CAS PubMed Google Scholar
• Patrignani, P. et al. Reduced thromboxane biosynthesis in carriers of Toll-like receptor 4 polymorphisms in vivo. Blood 107, 3572–3574 (2006).
  Article CAS PubMed Google Scholar
• Ståhl, A. L. et al. Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets via TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108, 167–176 (2006).
  Article PubMed PubMed Central CAS Google Scholar
• Zhang, G. et al. Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J. Immunol. 182, 7997–8004 (2009).
  Article CAS PubMed Google Scholar
• Welbourn, C. R. & Young, Y. Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators. Br. J. Surg. 79, 998–1003 (1992).
  Article CAS PubMed Google Scholar
• McClenahan, D. J., Evanson, O. A., Walcheck, B. K. & Weiss, D. J. Association among filamentous actin content, CD11b expression, and membrane deformability in stimulated and unstimulated bovine neutrophils. Amer. J. Vet. Res. 61, 380–386 (2000).
  Article CAS PubMed Google Scholar
• Ma, A. C. & Kubes, P. Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis. J. Thromb. Haemost. 6, 415–420 (2008).
  Article CAS PubMed Google Scholar
• Clark, S. R. et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nature Med. 13, 463–469 (2007). This elegant study provided evidence that platelets act as sensors of bacterial infection by demonstrating that activation of platelet TLR4 stimulates the binding of activated platelets to neutrophils, leading to the release of NETs to catch and kill bacteria.
  Article CAS PubMed Google Scholar
• Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532–1535 (2004).
  Article CAS PubMed Google Scholar
• Klesney-Tait, J., Turnbull, I. R. & Colonna, M. The TREM receptor family and signal integration. Nature Immunol. 7, 1266–1273 (2006).
  Article CAS Google Scholar
• Haselmayer, P., Grosse-Hovest, L., von Landenberg, P., Schild, H. & Radsak, M. P. TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 110, 1029–1035 (2007). In this article, the authors demonstrated that platelets express the ligand for TREM1, and showed that the binding of this molecule to neutrophil TREM1 augments LPS-induced neutrophil activation, and ultimately the innate inflammatory response.
  Article CAS PubMed Google Scholar
• Washington, A. V. et al. TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J. Clin. Invest. 119, 1489–1501 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Ross, R. Atherosclerosis: an inflammatory disease. N. Engl. J. Med. 340, 115–126 (1999).
  Article CAS PubMed Google Scholar
• Dong, Z. M., Brown, A. A. & Wagner, D. D. Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice. Circulation 101, 2290–2295 (2000).
  Article CAS PubMed Google Scholar
• Burger, P. C. & Wagner, D. D. Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101, 2661–2666 (2003).
  Article CAS PubMed Google Scholar
• Lindemann, S. et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis. J. Cell Biol. 154, 485–490 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Langer, H. F. & Gawaz, M. P. Platelet-vessel wall interactions in atherosclerotic disease. Thromb. Haemost. 99, 480–486 (2008).
  Article CAS PubMed Google Scholar
• Davi, G. & Patrono, C. Platelet activation and atherothrombosis. N. Engl. J. Med. 357, 2482–2494 (2007).
  Article CAS PubMed Google Scholar
• Langer, H. F. et al. Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro. Arterioscler. Thromb. Vasc. Biol. 27, 1463–1470 (2007).
  Article CAS PubMed Google Scholar
• Lievens, D. et al. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 116, 4317–4327 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Langer, H. F., Baughman, R. P., Lower, E. E., Flessa, H. C. & Tollerud, D. J. Thrombocytopenia in the intensive care unit. Chest 104, 1243–1247 (1993).
  Article Google Scholar
• Gawaz, M., Dickfeld, T., Bogner, C., Fateh-Moghadam, S. & Neumann, F. J. Platelet function in septic multiple organ dysfunction syndrome. Intensive Care Med. 23, 379–385 (1997).
  Article CAS PubMed Google Scholar
• Jacoby, R. C. et al. Platelet activation and function after trauma. J. Trauma 51, 639–647 (2001).
  Article CAS PubMed Google Scholar
• Ogura, H. et al. Activated platelets enhance microparticle formation and platelet–leukocyte interaction in severe trauma and sepsis. J. Trauma 50, 801–809 (2001).
  Article CAS PubMed Google Scholar
• Mause, S. F., von Hundelshausen, P., Zernecke, A., Koenen, R. R. & Weber, C. Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler. Thromb. Vasc. Biol. 25, 1512–1518 (2005).
  Article CAS PubMed Google Scholar
• Boman, H. G. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13, 61–92 (1995).
  Article CAS PubMed Google Scholar
• Yeaman, M. R., Puentes, S. M., Norman, D. C. & Bayer, A. S. Partial characterization and staphylocidal activity of thrombin-induced platelet microbicidal protein. Infect. Immun. 60, 1202–1209 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Krijgsveld, J. et al. Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. J. Biol. Chem. 275, 20374–20381 (2000).
  Article CAS PubMed Google Scholar
• Cox, D. & McConkey, S. The role of platelets in the pathogenesis of cerebral malaria. Cell. Mol. Life Sci. 67, 557–568 (2010).
  Article CAS PubMed Google Scholar
• McMorran, B. J. et al. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323, 797–800 (2009). This elegant study demonstrated that platelets can kill parasites in vitro and in mice, and found that platelet-deficient mice are more likely to die from malaria than mice with normal platelet counts. In addition, it showed that a single dose of aspirin may interfere with platelets sufficiently to prevent their killing power.
  Article CAS PubMed Google Scholar
• Choy, E. H. & Panayi, G. S. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. 344, 907–916 (2001).
  Article CAS PubMed Google Scholar
• Knijff-Dutmer, E. A., Koerts, J., Nieuwland, R., Kalsbeek-Batenburg, E. M. & van de Laar, M. A. Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis. Arthritis Rheum. 46, 1498–1503 (2002).
  Article CAS PubMed Google Scholar
• Boilard, E. et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327, 580–583 (2010). This interesting study described an essential role for platelet-derived microparticles in the development of the autoimmune disease rheumatoid arthritis, and identified the collagen receptor glycoprotein VI as a key stimulator of microparticle generation.
  Article CAS PubMed PubMed Central Google Scholar
• Looney, M. R., Gropper, M. A. & Matthay, M. A. Transfusion-related acute lung injury: a review. Chest 126, 249–258 (2004).
  Article PubMed Google Scholar
• Cognasse, F., Lafarge, S., Chavarin, P., Acquart, S. & Garraud, O. Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9. Intensive Care Med. 33, 382–384 (2007).
  Article PubMed Google Scholar
• Khan, S. Y. et al. Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood 108, 2455–2462 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Cines, D. B., Bussel, J. B., Liebman, H. A. & Luning Prak, E. T. The ITP syndrome: pathogenic and clinical diversity. Blood 113, 6511–6521 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Semple, J. W., Provan, D., Garvey, M. B. & Freedman, J. Recent progress in understanding the pathogenesis of immune thrombocytopenia (ITP). Curr. Opin. Haematol. 17, 590–595 (2010).
  Article CAS Google Scholar
• Semple, J. W. Infections, antigen presenting cells, T cells and immune tolerance: their role in the pathogenesis of immune thrombocytopenia (ITP). Hematol. Oncol. Clin. North Am. 23, 1177–1192 (2009).
  Article PubMed Google Scholar
• Harrington, W. J., Minnich, V., Hollingsworth, J. W. & Moore, C. V. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J. Lab. Clin. Med. 38, 1–10 (1951).
  CAS PubMed Google Scholar
• Evans, R. S., Takahashi, K., Duane, R. T., Payne, R. & Liu, C. Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology. Arch. Intern. Med. 87, 48–65 (1951).
  Article CAS Google Scholar
• Nardi, M., Tomlinson, S., Greco, M. & Karpatkin, S. Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia. Cell 106, 551–561 (2000).
  Article Google Scholar
• Olsson, B. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nature Med. 9, 1123–1124 (2003).
  Article CAS PubMed Google Scholar
• Delaflor-Weiss, E. & Mintz, P. D. The evaluation and management of platelet refractoriness and alloimmunization. Transfus. Med. Rev. 14, 180–196 (2000).
  Article CAS PubMed Google Scholar
• Landau, M. & Rosenberg, N. Molecular insight into human platelet antigens: structural and evolutionary conservation analyses offer new perspective to immunogenic disorders. Transfusion 51, 558–569 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Kaplan C. Neonatal alloimmune thrombocytopenia: a 50-year story. Immunohematology 23, 9–13 (2007).
  Article CAS PubMed Google Scholar
• Shtalrid, M. et al. Post-transfusion purpura: a challenging diagnosis. Isr. Med. Assoc. J. 8, 672–674 (2006).
  PubMed Google Scholar
• Kao, K. J., Cook, D. J. & Scornik, J. C. Quantitative analysis of platelet surface HLA by W6/32 anti-HLA monoclonal antibody. Blood 68, 627–632 (1986).
  Article CAS PubMed Google Scholar
• Gouttefangeas, C. et al. Thrombocyte HLA molecules retain nonrenewable endogenous peptides of megakaryocyte lineage and do not stimulate direct allocytotoxicity in vitro. Blood 95, 3168–3175 (2000).
  Article CAS PubMed Google Scholar
• Aslam, R., Speck, E. R., Kim, M., Freedman, J. & Semple, J. W. Transfusion-related immunomodulation (TRIM) by platelets is dependent on their expression of MHC class I molecules and is independent of leukocytes. Transfusion 48, 1778–1786 (2008).
  Article PubMed Google Scholar
• Chow, L. et al. A novel mouse model demonstrating both antibody- and T cell-mediated thrombocytopenia: differential response to therapy. Blood 115, 1247–1253 (2010).
  Article CAS PubMed Google Scholar
• Weyrich, A. S. & Zimmerman, G. A. Platelets: signaling cells in the immune continuum. Trends Immunol. 25, 489–495 (2004).
  CAS Google Scholar