Epigenetic regulation in psychiatric disorders (original) (raw)
Kendler, K. S. Twin studies of psychiatric illness: an update. Arch. Gen. Psychiatry58, 1005–1014 (2001). CASPubMed Google Scholar
Hyman, S. E. & Nestler, E. J. The Molecular Foundations of Psychiatry (American Psychiatric, Washington, D. C., 1993). Google Scholar
McClung, C. A. et al. ΔFosB: a molecular switch for long-term adaptation in the brain. Brain Res. Mol. Brain Res.132, 146–154 (2004). CASPubMed Google Scholar
Nestler, E. J., Barrot, M. & Self, D. W. ΔFosB: a sustained molecular switch for addiction. Proc. Natl Acad. Sci. USA98, 11042–11046 (2001). CASPubMedPubMed Central Google Scholar
Felsenfeld, G. & Groudine, M. Controlling the double helix. Nature421, 448–453 (2003). PubMed Google Scholar
Hake, S. B., Xiao, A. & Allis, C. D. Linking the epigenetic 'language' of covalent histone modifications to cancer. Br. J. Cancer90, 761–769 (2004). CASPubMedPubMed Central Google Scholar
Lachner, M. & Jenuwein, T. The many faces of histone lysine methylation. Curr. Opin. Cell Biol.14, 286–298 (2002). CASPubMed Google Scholar
Gill, G. SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev.18, 2046–2059 (2004). CASPubMed Google Scholar
Hassa, P. O., Haenni, S. S., Elser, M. & Hottiger, M. O. Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol. Mol. Biol. Rev.70, 789–829 (2006). CASPubMedPubMed Central Google Scholar
Jenuwein, T. & Allis, C. D. Translating the histone code. Science293, 1074–1080 (2001). CASPubMed Google Scholar
Narlikar, G. J., Fan, H. Y. & Kingston, R. E. Cooperation between complexes that regulate chromatin structure and transcription. Cell108, 475–487 (2002). CASPubMed Google Scholar
Shi, Y. et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell119, 941–953 (2004). CASPubMed Google Scholar
Brami-Cherrier, K. et al. Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. J. Neurosci.25, 11444–11454 (2005). Explores the signal transduction cascades, and their effect on downstream chromatin remodelling and associated gene expression, in striatal neurons in response to cocaine. It shows that cocaine causes induction of H4 acetylation, H3 phosphorylation and CREB phosphorylation through MSK1. CASPubMedPubMed Central Google Scholar
Kumar, A. et al. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron48, 303–314 (2005). Establishes an important role for chromatin remodelling in the reward responses to cocaine. Also, using chromatin immunoprecipitation assays, it shows that cocaine induces distinct histone modifications andin vivobinding of the transcription factor ΔFOSB at specific gene promoters in the striatum. CASPubMed Google Scholar
Li, J. et al. Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J. Neurochem.90, 1117–1131 (2004). Demonstrates that acute administration of antipsychotic drugs to rodents increases global levels of histone acetylation in the striatum and provides evidence for the signal transduction mechanisms that mediate this effect. CASPubMedPubMed Central Google Scholar
Crosio, C., Heitz, E., Allis, C. D., Borrelli, E. & Sassone-Corsi, P. Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J. Cell Sci.116, 4905–4914 (2003). CASPubMed Google Scholar
Bode, A. M. & Dong, Z. Inducible covalent posttranslational modification of histone H3. Sci. STKE2005, re4 (2005). PubMed Google Scholar
Chawla, S., Vanhoutte, P., Arnold, F. J., Huang, C. L. & Bading, H. Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J. Neurochem.85, 151–159 (2003). CASPubMed Google Scholar
Linseman, D. A. et al. Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca2+ //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival. J. Biol. Chem.278, 41472–41481 (2003). CASPubMed Google Scholar
Gregoire, S. et al. Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J. Biol. Chem.281, 4423–4433 (2006). CASPubMed Google Scholar
Berton, O. & Nestler, E. J. New approaches to antidepressant drug discovery: beyond monoamines. Nature Rev. Neurosci.7, 137–151 (2006). CAS Google Scholar
Tsankova, N. M., Kumar, A. & Nestler, E. J. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J. Neurosci.24, 5603–5610 (2004). Outlines a standardized approach to performing chromatin immunoprecipitation assays in rodent brain tissue. It also provides a detailed analysis of several transient and lasting changes in histone modifications after acute and chronic seizure, in correlation with changes in gene expression at the specific gene promoters. CASPubMedPubMed Central Google Scholar
Duman, R. S. Depression: a case of neuronal life and death? Biol. Psychiatry56, 140–145 (2004). PubMed Google Scholar
Nestler, E. J. et al. Neurobiology of depression. Neuron34, 13–25 (2002). CASPubMed Google Scholar
Duman, R. S. Role of neurotrophic factors in the etiology and treatment of mood disorders. Neuromolecular Med.5, 11–25 (2004). CASPubMed Google Scholar
Monteggia, L. M. et al. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc. Natl Acad. Sci. USA101, 10827–10832 (2004). CASPubMedPubMed Central Google Scholar
Monteggia, L. M. et al. Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol. Psychiatry61, 187–197 (2006). PubMed Google Scholar
Berton, O. et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science311, 864–868 (2006). The authors use chronic social defeat stress as an animal model of depression and demonstrate a crucial role for the neurotrophic factor BDNF in the mesolimbic dopamine pathway in mediating some of the deleterious molecular and behavioural sequelae of this stress paradigm. CASPubMed Google Scholar
Tsankova, N. M. et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature Neurosci.9, 519–525 (2006). The first study to examine the involvement of chromatin remodelling in an animal model of depression. It reveals robust and lastingin vivochanges in histone modifications, and a role for HDAC5 in chronic social defeat stress and in antidepressant efficacy. CASPubMed Google Scholar
Schroeder, F. A., Lin, C. L., Crusio, W. E. & Akbarian, S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse (in the press).
Lee, M. G., Wynder, C., Schmidt, D. M., McCafferty, D. G. & Shiekhattar, R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem. Biol.13, 563–567 (2006). CASPubMed Google Scholar
Champagne, F. A., Francis, D. D., Mar, A. & Meaney, M. J. Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol. Behav.79, 359–371 (2003). CASPubMed Google Scholar
Meaney, M. J. & Szyf, M. Maternal care as a model for experience-dependent chromatin plasticity? Trends Neurosci.28, 456–463 (2005). CASPubMed Google Scholar
Weaver, I. C. et al. Epigenetic programming by maternal behavior. Nature Neurosci.7, 847–854 (2004). This important study provides highly novel evidence that the epigenetic state ofGRin the hippocampus of rodent offspring, in particular its level of DNA methylation, can be modulated by maternal nurturing behavior in a lasting but reversible manner. CASPubMed Google Scholar
Levenson, J. M. et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J. Biol. Chem.281, 15763–15773 (2006). Along with reference 69, this study implicates rapid and reversible changes in DNA methylation in synaptic plasticity in the rodent hippocampus, and in the formation of long-term memory. The notion that DNA methylation is subject to dynamic regulation in the adult brain is highly novel and has important implications for our understanding of the epigenetic control of brain function. CASPubMed Google Scholar
Everitt, B. J. & Robbins, T. W. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nature Neurosci.8, 1481–1489 (2005). CASPubMed Google Scholar
Hyman, S. E., Malenka, R. C. & Nestler, E. J. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci.29, 565–598 (2006). CASPubMed Google Scholar
Freeman, W. M. et al. Cocaine-responsive gene expression changes in rat hippocampus. Neuroscience108, 371–380 (2001). CASPubMed Google Scholar
Freeman, W. M. et al. Changes in rat frontal cortex gene expression following chronic cocaine. Brain Res. Mol. Brain Res.104, 11–20 (2002). CASPubMed Google Scholar
Kreek, M. J., Bart, G., Lilly, C., LaForge, K. S. & Nielsen, D. A. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev.57, 1–26 (2005). CASPubMed Google Scholar
McClung, C. A. & Nestler, E. J. Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nature Neurosci.6, 1208–1215 (2003). CASPubMed Google Scholar
McClung, C. A. et al. Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J. Neurosci.25, 6005–6015 (2005). CASPubMedPubMed Central Google Scholar
Yao, W. D. et al. Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron41, 625–638 (2004). CASPubMed Google Scholar
Grimm, J. W. et al. Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J. Neurosci.23, 742–747 (2003). CASPubMedPubMed Central Google Scholar
Colvis, C. M. et al. Epigenetic mechanisms and gene networks in the nervous system. J. Neurosci.25, 10379–10389 (2005). CASPubMedPubMed Central Google Scholar
Levine, A. A. et al. CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc. Natl Acad. Sci. USA102, 19186–19191 (2005). Characterizes the influence of chromatin remodelling on cocaine action in the brain. In particular, it shows that recruitment of CBP to theFosBpromoter and the resulting H4 acetylation are essential for normal levels ofFosBexpression, for accumulation of the transcription factor ΔFOSB, and for normal sensitivity to cocaine. CASPubMedPubMed Central Google Scholar
Bibb, J. A. et al. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature410, 376–380 (2001). CASPubMed Google Scholar
Lee, M. P. Genome-wide analysis of epigenetics in cancer. Ann. NY Acad. Sci.983, 101–109 (2003). CASPubMed Google Scholar
Lee, T. I. et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell125, 301–313 (2006). CASPubMedPubMed Central Google Scholar
Impey, S. et al. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell119, 1041–1054 (2004). Introduces a novel method of genome-wide analysis of transcription factor binding sites, termed SACO, which combines chromatin immunoprecipitation with long serial analysis of gene expression by direct sequencing rather than by the use of microarray chips. CASPubMed Google Scholar
Kumar, A. et al. Global maps of histone acetylation and gene regulatory networks in the nucleus accumbens after chronic cocaine using chip on chip. Soc. Neurosci. Abstr. 451.4 (2005).
Kumar, A. et al. Transcriptional and post-transcriptional regulation of gene expression in nucleus accumbens associated with chronic stress-induced neuroadaptations in mouse. Soc. Neurosci. Abstr. 191.23 (2006).
Renthal, W. et al. Epigenetic control of cocaine reward by class II histone deacetylases. Soc. Neurosci. Abstr. 294.27 (2006).
Norrholm, S. D. et al. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Neuroscience116, 19–22 (2003). CASPubMed Google Scholar
Cassel, S. et al. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Mol. Pharmacol.70, 487–492 (2006). CASPubMed Google Scholar
Li, Z. et al. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J. Biol. Chem.279, 54438–54444 (2004). CASPubMed Google Scholar
Korutla, L., Wang, P. J. & Mackler, S. A. The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. J. Neurochem.94, 786–793 (2005). CASPubMed Google Scholar
Mahadev, K. & Vemuri, M. C. Effect of ethanol on chromatin and nonhistone nuclear proteins in rat brain. Neurochem. Res.23, 1179–1184 (1998). CASPubMed Google Scholar
Bonsch, D., Lenz, B., Kornhuber, J. & Bleich, S. DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport16, 167–170 (2005). PubMed Google Scholar
Kim, J. S. & Shukla, S. D. Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissues. Alcohol Alcohol.41, 126–132 (2006). CASPubMed Google Scholar
Bailey, C. H., Kandel, E. R. & Si, K. The persistence of long-term memory: a molecular approach to self-sustaining changes in learning-induced synaptic growth. Neuron44, 49–57 (2004). CASPubMed Google Scholar
Levenson, J. M. & Sweatt, J. D. Epigenetic mechanisms in memory formation. Nature Rev. Neurosci.6, 108–118 (2005). CAS Google Scholar
Alarcon, J. M. et al. Chromatin acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein–Taybi syndrome and its amelioration. Neuron42, 947–959 (2004). CASPubMed Google Scholar
Korzus, E., Rosenfeld, M. G. & Mayford, M. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron42, 961–972 (2004). CASPubMedPubMed Central Google Scholar
Levenson, J. M. et al. Regulation of histone acetylation during memory formation in the hippocampus. J. Biol. Chem.279, 40545–40559 (2004). CASPubMed Google Scholar
Chwang, W. B., O'Riordan, K. J., Levenson, J. M. & Sweatt, J. D. ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning. Learn. Mem.13, 322–328 (2006). CASPubMedPubMed Central Google Scholar
Kim, Y. et al. Epigenetic regulation of brain function by Polycomb and Trithorax complexes. Soc. Neurosci. Abstr. 750.5 (2006).
Guan, Z. et al. Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell111, 483–493 (2002). CASPubMed Google Scholar
Miller, C. A. & Sweatt, J. D. Covalent modification of DNA regulates memory formation. Neuron53, 857–869 (2007). Demonstrates rapid changes in the methylation of several memory-related genes (for example,Bdnf, PP1and reelin) in the hippocampus during contextual fear conditioning. The study, along with reference 35, provides one of the best indications so far that DNA methylation may be rapidly induced and reversed in the adult brain. CASPubMed Google Scholar
Ausio, J., Levin, D. B., De Amorim, G. V., Bakker, S. & Macleod, P. M. Syndromes of disordered chromatin remodeling. Clin. Genet.64, 83–95 (2003). CASPubMed Google Scholar
Zoghbi, H. Y. MeCP2 dysfunction in humans and mice. J. Child Neurol.20, 736–740 (2005). PubMed Google Scholar
Amir, R. E. et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genet.23, 185–188 (1999). CASPubMed Google Scholar
Luikenhuis, S., Giacometti, E., Beard, C. F. & Jaenisch, R. Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc. Natl Acad. Sci. USA101, 6033–6038 (2004). CASPubMedPubMed Central Google Scholar
Dani, V. S. et al. Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc. Natl Acad. Sci. USA102, 12560–12565 (2005). CASPubMedPubMed Central Google Scholar
Chang, Q., Khare, G., Dani, V., Nelson, S. & Jaenisch, R. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron49, 341–348 (2006). CASPubMed Google Scholar
Gemelli, T. et al. Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biol. Psychiatry59, 468–476 (2006). CASPubMed Google Scholar
Moretti, P. et al. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J. Neurosci.26, 319–327 (2006). CASPubMedPubMed Central Google Scholar
Nelson, E. D., Kavalali, E. T. & Monteggia, L. M. MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Curr. Biol.16, 710–716 (2006). Characterizes abnormalities in presynaptic excitatory transmission in cultured hippocampal neurons from mice lacking MeCP2. It shows that such abnormalities are not developmental in nature, but rather can be induced in adult neurons by deletion ofMecp2and, conversely, that the consequences of early gene deletion can be corrected by inhibitors of transcription. CASPubMed Google Scholar
Chen, R. Z., Akbarian, S., Tudor, M. & Jaenisch, R. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nature Genet.27, 327–331 (2001). CASPubMed Google Scholar
McGill, B. E. et al. Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc. Natl Acad. Sci. USA103, 18267–18272 (2006). CASPubMedPubMed Central Google Scholar
Guy, J., Gan, J., Selfridge, J., Cobb, S. & Bird, A. Reversal of neurological defects in a mouse model of Rett syndrome. Science315, 1143–1147 (2007). Shows that Rett-like symptoms induced in mice as a result of loss of function mutations in MeCP2 can be largely reversed upon correction of the MeCP2 deficit. This supports the notion that it may be possible to treat Rett syndrome in humans even after it has become symptomatic. CASPubMedPubMed Central Google Scholar
Tremolizzo, L. et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc. Natl Acad. Sci. USA99, 17095–17100 (2002). CASPubMedPubMed Central Google Scholar
Tamminga, C. A. & Holcomb, H. H. Phenotype of schizophrenia: a review and formulation. Mol. Psychiatry10, 27–39 (2005). CASPubMed Google Scholar
Grayson, D. R. et al. The human reelin gene: transcription factors (+), repressors (−) and the methylation switch (+/−) in schizophrenia. Pharmacol. Ther.111, 272–286 (2006). CASPubMed Google Scholar
Chen, Y., Sharma, R. P., Costa, R. H., Costa, E. & Grayson, D. R. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res.30, 2930–2939 (2002). CASPubMedPubMed Central Google Scholar
Dong, E. et al. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc. Natl Acad. Sci. USA102, 12578–12583 (2005). Provides evidence to support their hypothesis that epigenetic abnormalities, specifically, altered methylation of the reelin andGad67gene promoters, contribute to the pathophysiology of schizophrenia in a mouse model. CASPubMedPubMed Central Google Scholar
Antun, F. T. et al. The effects of L-methionine (without MAOI) in schizophrenia. J. Psychiatr. Res.8, 63–71 (1971). CASPubMed Google Scholar
Tremolizzo, L. et al. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol. Psychiatry57, 500–509 (2005). CASPubMed Google Scholar
Cervoni, N. & Szyf, M. Demethylase activity is directed by histone acetylation. J. Biol. Chem.276, 40778–84077 (2001). CASPubMed Google Scholar
Cervoni, N., Detich, N., Seo, S. B., Chakravarti, D. & Szyf, M. The oncoprotein Set/TAF-1β, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. J. Biol. Chem.277, 25026–25031 (2002). CASPubMed Google Scholar
Casey, D. E. et al. Effect of divalproex combined with olanzapine or risperidone in patients with an acute exacerbation of schizophrenia. Neuropsychopharmacology28, 182–192 (2003). CASPubMed Google Scholar
Tsankov, A. M. et al. Communication between levels of transcriptional control improves robustness and adaptivity. Mol. Syst. Biol.2, 65 (2006). Provides a system-level view of how transcription factors, chromatin regulators, RNA processing and nuclear transport proteins affect gene expression, revealing an elegant architecture for transcriptional control that improves the resilience and responsiveness of the eukaryotic cell. PubMedPubMed Central Google Scholar
Hsieh, J. & Gage, F. H. Chromatin remodeling in neural development and plasticity. Curr. Opin. Cell Biol.17, 664–671 (2005). CASPubMed Google Scholar
Ballas, N. & Mandel, G. The many faces of REST oversee epigenetic programming of neuronal genes. Curr. Opin. Neurobiol.15, 500–506 (2005). CASPubMed Google Scholar
Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K. & Gage, F. H. A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell116, 779–793 (2004). CASPubMed Google Scholar
Marin-Husstege, M., Muggironi, M., Liu, A. & Casaccia-Bonnefil, P. Histone deacetylase activity is necessary for oligodendrocyte lineage progression. J. Neurosci.22, 10333–10345 (2002). CASPubMedPubMed Central Google Scholar
Fan, G. et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci.21, 788–797 (2001). CASPubMedPubMed Central Google Scholar
Zhao, X. et al. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl Acad. Sci. USA100, 6777–6782 (2003). CASPubMedPubMed Central Google Scholar
Liu, Q. R. et al. Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res.1067, 1–12 (2006). CASPubMed Google Scholar
Timmusk, T. et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron10, 475–489 (1993). CASPubMed Google Scholar
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J. & Greenberg, M. E. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron20, 709–726 (1998). CASPubMed Google Scholar
Chen, W. G. et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science302, 885–889 (2003). CASPubMed Google Scholar
Zhou, Z. et al. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron52, 255–269 (2006). CASPubMedPubMed Central Google Scholar
Huang, Y., Doherty, J. J. & Dingledine, R. Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. J. Neurosci.22, 8422–8428 (2002). The first paper to demonstrate regulation of histone acetylation in the adult rat brain. The authors characterize rapid changes in acetylation at theBdnfandGlur2promoters in response to chemically induced seizures. CASPubMedPubMed Central Google Scholar
Lim, J. H., Booker, A. B. & Fallon, J. R. Regulating fragile X gene transcription in the brain and beyond. J. Cell Physiol.205, 170–175 (2005). CASPubMed Google Scholar
Merienne, K., Pannetier, S., Harel-Bellan, A. & Sassone-Corsi, P. Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities. Mol. Cell Biol.21, 7089–7096 (2001). CASPubMedPubMed Central Google Scholar
Weeber, E. J., Levenson, J. M. & Sweatt, J. D. Molecular genetics of human cognition. Mol. Interv.2, 376–91, 339 (2002). CASPubMed Google Scholar
Davies, W., Isles, A. R. & Wilkinson, L. S. Imprinted gene expression in the brain. Neurosci. Biobehav. Rev.29, 421–430 (2005). CASPubMed Google Scholar
Vo, N. & Goodman, R. H. CREB-binding protein and p300 in transcriptional regulation. J. Biol. Chem.276, 13505–13508 (2001). CASPubMed Google Scholar