Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease (original) (raw)
Kraeplin, E. Compendium der Psychiatrie zum Gebrauch fuer Studierende und Aerzte (Abel Verlag, Leipzig, 1883). Google Scholar
Papousek, M. [Chronobiological aspects of cyclothymia (author's transl)]. Fortschr. Neurol. Psychiatr. Grenzgeb.43, 381–440 (1975). CASPubMed Google Scholar
Wehr, T. A., Sack, D., Rosenthal, N., Duncan, W. & Gillin, J. C. Circadian rhythm disturbances in manic-depressive illness. Fed. Proc.42, 2809–2814 (1983). CASPubMed Google Scholar
Wirz-Justice, A., Puhringer, W. & Hole, G. Sleep deprivation and clomipramine in endogenous depression. Lancet2, 912 (1976). ArticleCASPubMed Google Scholar
Wirz-Justice, A. et al. Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors. Psychiatry Res.5, 67–76 (1981). ArticleCASPubMed Google Scholar
Cirelli, C. The genetic and molecular regulation of sleep: from fruit flies to humans. Nature Rev. Neurosci.10, 549–560 (2009). ArticleCAS Google Scholar
Wirz-Justice, A. Biological rhythm disturbances in mood disorders. Int. Clin. Psychopharmacol.21, (Suppl. 1) 11–15 (2006). Article Google Scholar
Wirz-Justice, A., Haug, H. J. & Cajochen, C. Disturbed circadian rest–activity cycles in schizophrenia patients: an effect of drugs? Schizophr. Bull.27, 497–502 (2001). ArticleCASPubMed Google Scholar
Smith, M. T., Perlis, M. L., Smith, M. S., Giles, D. E. & Carmody, T. P. Sleep quality and presleep arousal in chronic pain. J. Behav. Med.23, 1–13 (2000). ArticleCASPubMed Google Scholar
Takahashi, J. S., Hong, H. K., Ko, C. H. & McDearmon, E. L. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nature Rev. Genet.9, 764–775 (2008). ArticleCASPubMed Google Scholar
Mieda, M. & Sakurai, T. Integrative physiology of orexins and orexin receptors. CNS Neurol. Disord. Drug Targets8, 281–295 (2009). ArticleCASPubMed Google Scholar
Feder, A., Nestler, E. J. & Charney, D. S. Psychobiology and molecular genetics of resilience. Nature Rev. Neurosci.10, 446–457 (2009). ArticleCAS Google Scholar
Wulff, K., Porcheret, K., Cussans, E. & Foster, R. G. Sleep and circadian rhythm disturbances: multiple genes and multiple phenotypes. Curr. Opin. Genet. Dev.19, 237–246 (2009). ArticleCASPubMed Google Scholar
Armitage, R. Sleep and circadian rhythms in mood disorders. Acta Psychiatr. Scand. Suppl.115, 104–115 (2007). Article Google Scholar
Schibler, U. The daily timing of gene expression and physiology in mammals. Dialogues Clin. Neurosci.9, 257–272 (2007). PubMedPubMed Central Google Scholar
Katz, G., Durst, R., Zislin, Y., Barel, Y. & Knobler, H. Y. Psychiatric aspects of jet lag: review and hypothesis. Med. Hypotheses56, 20–23 (2001). ArticleCASPubMed Google Scholar
Benedetti, F., Barbini, B., Colombo, C. & Smeraldi, E. Chronotherapeutics in a psychiatric ward. Sleep Med. Rev.11, 509–522 (2007). ArticlePubMed Google Scholar
Wirz-Justice, A. & Van den Hoofdakker, R. H. Sleep deprivation in depression: what do we know, where do we go? Biol. Psychiatry46, 445–453 (1999). ArticleCASPubMed Google Scholar
Bunney, J. N. & Potkin, S. G. Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Br. Med. Bull.86, 23–32 (2008). ArticleCASPubMed Google Scholar
Pigeon, W. R. et al. Is insomnia a perpetuating factor for late-life depression in the IMPACT cohort? Sleep31, 481–488 (2008). ArticlePubMedPubMed Central Google Scholar
Posmontier, B. Sleep quality in women with and without postpartum depression. J. Obstet. Gynecol. Neonatal Nurs.37, 722–735; (2008). ArticlePubMedPubMed Central Google Scholar
Asnis, G. M. et al. Zolpidem for persistent insomnia in SSRI-treated depressed patients. J. Clin. Psychiatry60, 668–676 (1999). ArticleCASPubMed Google Scholar
Krystal, A. D., Thakur, M. & Roth, T. Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. Ann. Clin. Psychiatry20, 39–46 (2008). ArticlePubMed Google Scholar
Kasper, S. et al. Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline. J. Clin. Psychiatry71, 109–120 (2010). ArticleCASPubMed Google Scholar
Lopes, M. C., Quera-Salva, M. A. & Guilleminault, C. Non-REM sleep instability in patients with major depressive disorder: subjective improvement and improvement of non-REM sleep instability with treatment (Agomelatine). Sleep Med.9, 33–41 (2007). ArticlePubMed Google Scholar
Olie, J. P. & Kasper, S. Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder. Int. J. Neuropsychopharmacol.10, 661–673 (2007). CASPubMed Google Scholar
Quera-Salva, M. A., Lemoine, P. & Guilleminault, C. Impact of the novel antidepressant agomelatine on disturbed sleep–wake cycles in depressed patients. Hum. Psychopharmacol.25, 222–229 (2010). ArticleCASPubMed Google Scholar
Fava, M. et al. Modafinil augmentation of selective serotonin reuptake inhibitor therapy in MDD partial responders with persistent fatigue and sleepiness. Ann. Clin. Psychiatry19, 153–159 (2007). ArticlePubMed Google Scholar
Modell, S., Huber, J., Holsboer, F. & Lauer, C. J. The munich vulnerability study on affective disorders: risk factors for unipolarity versus bipolarity. J. Affect. Disord.74, 173–184 (2003). ArticlePubMed Google Scholar
Rao, U. et al. Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course. J. Affect. Disord.70, 273–280 (2002). ArticlePubMed Google Scholar
Gregory, A. M., Cox, J., Crawford, M. R., Holland, J. & Haravey, A. G. Dysfunctional beliefs and attitudes about sleep in children. J. Sleep Res.18, 422–426 (2009). ArticlePubMed Google Scholar
Levitt, A. J. & Boyle, M. H. The impact of latitude on the prevalence of seasonal depression. Can. J. Psychiatry47, 361–367 (2002). ArticlePubMed Google Scholar
Axelsson, J., Ragnarsdottir, S., Pind, J. & Sigbjornsson, R. Daylight availability: a poor predictor of depression in Iceland. Int. J. Circumpolar Health63, 267–276 (2004). ArticlePubMed Google Scholar
Lavoie, M. P. et al. Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder. Biol. Psychiatry66, 253–258 (2009). ArticlePubMed Google Scholar
Hankins, M. W., Peirson, S. N. & Foster, R. G. Melanopsin: an exciting photopigment. Trends Neurosci.31, 27–36 (2008). ArticleCASPubMed Google Scholar
Plante, D. T. & Winkelman, J. W. Sleep disturbance in bipolar disorder: therapeutic implications. Am. J. Psychiatry165, 830–843 (2008). ArticlePubMed Google Scholar
Young, A. H. Antiglucocoticoid treatments for depression. Aust. N. Z. J. Psychiatry40, 402–405 (2006). ArticlePubMed Google Scholar
Roybal, K. et al. Mania-like behavior induced by disruption of CLOCK. Proc. Natl Acad. Sci. USA104, 6406–6411 (2007). ArticleCASPubMed Google Scholar
Salvatore, P. et al. Circadian activity rhythm abnormalities in ill and recovered bipolar I disorder patients. Bipolar Disord.10, 256–265 (2008). ArticlePubMed Google Scholar
Benedetti, F. et al. A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci. Lett.445, 184–187 (2008). ArticleCASPubMed Google Scholar
Bellivier, F. et al. Age at onset in bipolar I affective disorder: further evidence for three subgroups. Am. J. Psychiatry160, 999–1001 (2003). ArticlePubMed Google Scholar
Conus, P. et al. The proximal prodrome to first episode mania — a new target for early intervention. Bipolar Disord.10, 555–565 (2008). ArticlePubMed Google Scholar
Modell, S., Ising, M., Holsboer, F. & Lauer, C. J. The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands. Biol. Psychiatry58, 694–699 (2005). ArticlePubMed Google Scholar
Roehrs, T. & Roth, T. Sleep, sleepiness, sleep disorders and alcohol use and abuse. Sleep Med. Rev.5, 287–297 (2001). ArticlePubMed Google Scholar
Krystal, A. D. Treating the health, quality of life, and functional impairments in insomnia. J. Clin. Sleep Med.3, 63–72 (2007). PubMed Google Scholar
Hatonen, T., Forsblom, S., Kieseppa, T., Lonnqvist, J. & Partonen, T. Circadian phenotype in patients with the co-morbid alcohol use and bipolar disorders. Alcohol Alcohol.43, 564–568 (2008). ArticlePubMed Google Scholar
Spanagel, R. et al. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nature Med.11, 35–42 (2005). ArticleCASPubMed Google Scholar
Franken, P., Thomason, R., Heller, H. C. & O'Hara, B. F. A non-circadian role for clock-genes in sleep homeostasis: a strain comparison. BMC Neurosci.8, 87 (2007). ArticleCASPubMedPubMed Central Google Scholar
Rodd, Z. A. et al. Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. Pharmacogenomics J.7, 222–256 (2007). ArticleCASPubMed Google Scholar
Francks, C. et al. Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13. Mol. Psychiatry15, 319–325 (2008). ArticleCASPubMed Google Scholar
Hendler, T., Bleich-Cohen, M. & Sharon, H. Neurofunctional view of psychiatry: clinical brain imaging revisited. Curr. Opin. Psychiatry22, 300–305 (2009). ArticlePubMed Google Scholar
Stahl, S. M. & Buckley, P. F. Negative symptoms of schizophrenia: a problem that will not go away. Acta Psychiatr. Scand.115, 4–11 (2007). ArticleCASPubMed Google Scholar
Van Cauter, E. et al. Circadian and sleep-related endocrine rhythms in schizophrenia. Arch Gen Psychiatry48, 348–356 (1991). ArticleCASPubMed Google Scholar
Cohrs, S. Sleep disturbances in patients with schizophrenia: impact and effect of antipsychotics. CNS Drugs22, 939–962 (2008). ArticleCASPubMed Google Scholar
Auslander, L. A. & Jeste, D. V. Perceptions of problems and needs for service among middle-aged and elderly outpatients with schizophrenia and related psychotic disorders. Community Ment. Health J.38, 391–402 (2002). ArticlePubMed Google Scholar
Hofstetter, J. R., Lysaker, P. H. & Mayeda, A. R. Quality of sleep in patients with schizophrenia is associated with quality of life and coping. BMC Psychiatry5, 13 (2005). ArticlePubMedPubMed Central Google Scholar
Tomppo, L. et al. Association of variants in DISC1 with psychosis-related traits in a large population cohort. Arch. Gen. Psychiatry66, 134–141 (2009). ArticlePubMedPubMed Central Google Scholar
Sawamura, N. et al. Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol. Psychiatry13, 1138–1148 (2008). ArticleCASPubMedPubMed Central Google Scholar
Gottlieb, D. J., O'Connor, G. T. & Wilk, J. B. Genome-wide association of sleep and circadian phenotypes. BMC Med. Genet.8, (Suppl. 1) 9 (2007). ArticleCAS Google Scholar
Tomppo, L. et al. Association between genes of disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol. Psychiatry65, 1055–1062 (2009). ArticleCASPubMedPubMed Central Google Scholar
Takao, T., Tachikawa, H., Kawanishi, Y., Mizukami, K. & Asada, T. CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: a preliminary study. Eur. Neuropsychopharmacol.17, 3273–3276 (2007). ArticleCAS Google Scholar
Ding, J. M. et al. Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO. Science266, 1713–1717 (1994). ArticleCASPubMed Google Scholar
Young, C. E. et al. SNAP-25 deficit and hippocampal connectivity in schizophrenia. Cereb. Cortex8, 261–268 (1998). ArticleCASPubMed Google Scholar
Oliver, P. L. & Davies, K. E. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind–drunk. Hum. Mol. Genet.18, 4576–4589 (2009). ArticleCASPubMedPubMed Central Google Scholar
Deery, M. J. et al. Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock. Curr. Biol.19, 2031–2036 (2009). ArticleCASPubMed Google Scholar
Monti, J. M. & Monti, D. Sleep disturbance in generalized anxiety disorder and its treatment. Sleep Med. Rev.4, 263–276 (2000). ArticlePubMed Google Scholar
Papadimitriou, G. N. & Linkowski, P. Sleep disturbance in anxiety disorders. Int. Rev. Psychiatry17, 229–236 (2005). ArticlePubMed Google Scholar
Xu, Y. L. et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron43, 487–497 (2004). ArticleCASPubMed Google Scholar
Reinscheid, R. K. & Xu, Y. L. Neuropeptide S as a novel arousal promoting peptide transmitter. FEBS J.272, 5689–5693 (2005). ArticleCASPubMed Google Scholar
Okamura, N. & Reinscheid, R. K. Neuropeptide S: a novel modulator of stress and arousal. Stress10, 221–226 (2007). ArticleCASPubMed Google Scholar
Leonard, S. K. et al. Pharmacology of neuropeptide S. in mice: therapeutic relevance to anxiety disorders. Psychopharmacology (Berlin)197, 601–611 (2008). ArticleCAS Google Scholar
Reinscheid, R. K. Neuropeptide S: anatomy, pharmacology, genetics and physiological functions. Results Probl. Cell Differ.46, 145–158 (2008). ArticleCASPubMed Google Scholar
Okamura, N. et al. Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry31, 1444–1448 (2007). ArticleCASPubMed Google Scholar
Bohnen, N. I. & Albin, R. L. The cholinergic system and Parkinson disease. Behav. Brain Res. 7 Jan 2010 (doi:10.1016/j.bbr.2009.12.048).
Jeong, J. EEG dynamics in patients with Alzheimer's disease. Clin. Neurophysiol.115, 1490–1505 (2004). ArticlePubMed Google Scholar
Hofman, M. A. & Swaab, D. F. Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res.651, 134–142 (1994). ArticleCASPubMed Google Scholar
Vitiello, M. V., Prinz, P. N., Williams, D. E., Frommlet, M. S. & Ries, R. K. Sleep disturbances in patients with mild-stage Alzheimer's disease. J. Gerontol.45, M131–M138 (1990). ArticleCASPubMed Google Scholar
Clemens, Z., Fabo, D. & Halasz, P. Overnight verbal memory retention correlates with the number of sleep spindles. Neuroscience132, 529–535 (2005). ArticleCASPubMed Google Scholar
Tractenberg, R. E., Singer, C. M. & Kaye, J. A. Characterizing sleep problems in persons with Alzheimer's disease and normal elderly. J. Sleep Res.15, 97–103 (2006). ArticlePubMedPubMed Central Google Scholar
Zhou, J. N., Liu, R. Y., Kamphorst, W., Hofman, M. A. & Swaab, D. F. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J. Pineal Res.35, 125–130 (2003). ArticleCASPubMed Google Scholar
Dowling, G. A. et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J. Am. Geriatr. Soc.56, 239–246 (2008). ArticlePubMed Google Scholar
Parkinson, J. An essay on the shaking palsy. 1817. J. Neuropsychiatry Clin. Neurosci. 14, 223–236 (2002); discussion in 14, 222 (2002). Article Google Scholar
Arnulf, I., Leu, S. & Oudiette, D. Abnormal sleep and sleepiness in Parkinson's disease. Curr. Opin. Neurol.21, 472–477 (2008). ArticlePubMed Google Scholar
Willis, G. L., Kelly, A. M. & Kennedy, G. A. Compromised circadian function in Parkinson's disease: enucleation augments disease severity in the unilateral model. Behav. Brain Res.193, 37–47 (2008). ArticleCASPubMed Google Scholar
Metzler-Baddeley, C. A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia. Cortex43, 583–600 (2007). ArticlePubMed Google Scholar
Kassubek, J. et al. Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study. J. Neurol. Neurosurg. Psychiatry75, 213–220 (2004). CASPubMedPubMed Central Google Scholar
Rosas, H. D. et al. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology60, 1615–1620 (2003). ArticleCASPubMed Google Scholar
Morton, A. J. et al. Disintegration of the sleep–wake cycle and circadian timing in Huntington's disease. J. Neurosci.25, 157–163 (2005). ArticleCASPubMed Google Scholar
Goodman, A. O. & Barker, R. A. How vital is sleep in Huntington's disease? J. Neurol.257, 882–897 (2010). ArticleCASPubMed Google Scholar
Pallier, P. N. et al. Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J. Neurosci.27, 7869–7878 (2007). ArticleCASPubMed Google Scholar
Pallier, P. N. & Morton, A. J. Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease. Brain Res.1279, 90–98 (2009). ArticleCASPubMed Google Scholar
Taphoorn, M. J. et al. Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis. J. Neurol.240, 446–448 (1993). ArticleCASPubMed Google Scholar
Attarian, H. P., Brown, K. M., Duntley, S. P., Carter, J. D. & Cross, A. H. The relationship of sleep disturbances and fatigue in multiple sclerosis. Arch. Neurol.61, 525–528 (2004). ArticlePubMed Google Scholar
Gallup, A. C., Gallup, G. G. Jr. & Feo, C. Yawning, sleep, and symptom relief in patients with multiple sclerosis. Sleep Med.11, 329–330 (2010). ArticlePubMed Google Scholar
Mendozzi, L., Tronci, F., Garegnani, M. & Pugnetti, L. Sleep disturbance and fatigue in mild relapsing remitting multiple sclerosis patients on chronic immunomodulant therapy: an actigraphic study. Mult. Scler.16, 238–247 (2010). ArticlePubMed Google Scholar
Ceccarelli, A. et al. T2 hypointensity in the deep gray matter of patients with benign multiple sclerosis. Mult. Scler.15, 678–686 (2009). ArticleCASPubMed Google Scholar
Auer, R. N., Rowlands, C. G., Perry, S. F. & Remmers, J. E. Multiple sclerosis with medullary plaques and fatal sleep apnea (Ondine's curse). Clin. Neuropathol.15, 101–105 (1996). CASPubMed Google Scholar
Wirz-Justice, A., Benedetti, F. & Terman, M. Chronotherapeutics for Affective Disorders (Karger, Basel, 2009). Book Google Scholar
Damiola, F. et al. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev.14, 2950–2961 (2000). ArticleCASPubMedPubMed Central Google Scholar
Goetz, F. et al. Timing of single daily meal influences relations among human circadian rhythms in urinary cyclic AMP and hemic glucagon, insulin and iron. Experientia32, 1081–1084 (1976). ArticleCASPubMed Google Scholar
Riemann, D. et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med. Rev.14, 19–31 (2010). ArticlePubMed Google Scholar
Pace-Schott, E. F. & Hobson, J. A. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nature Rev. Neurosci.3, 591–605 (2002). ArticleCAS Google Scholar
Diniz Behn, C. G., Kopell, N., Brown, E. N., Mochizuki, T. & Scammell, T. E. Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J. Neurophysiol.99, 3090–3103 (2008). ArticleCASPubMedPubMed Central Google Scholar
Behn, C. G., Brown, E. N., Scammell, T. E. & Kopell, N. J. Mathematical model of network dynamics governing mouse sleep-wake behavior. J. Neurophysiol.97, 3828–3840 (2007). ArticlePubMedPubMed Central Google Scholar
Lockley, S. W. et al. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep29, 161–168 (2006). Google Scholar
Scheer, F. A., Wright, K. P. Jr, Kronauer, R. E. & Czeisler, C. A. Plasticity of the intrinsic period of the human circadian timing system. PLoS ONE2, e721 (2007). ArticlePubMedPubMed Central Google Scholar
Meijer, J. H., Michel, S. & Vansteensel, M. J. Processing of daily and seasonal light information in the mammalian circadian clock. Gen. Comp. Endocrinol.152, 159–164 (2007). ArticleCASPubMed Google Scholar
Buijs, R. M., van Eden, C. G., Goncharuk, V. D. & Kalsbeek, A. The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J. Endocrinol.177, 17–26 (2003). ArticleCASPubMed Google Scholar
Lupi, D., Oster, H., Thompson, S. & Foster, R. G. The acute light-induction of sleep is mediated by OPN4-based photoreception. Nature Neurosci.11, 1068–1073 (2008). ArticleCASPubMed Google Scholar
Ko, C. H. & Takahashi, J. S. Molecular components of the mammalian circadian clock. Hum. Mol. Genet.15, R271–R277 (2006). ArticleCASPubMed Google Scholar
Schibler, U. The 2008 Pittendrigh/Aschoff lecture: peripheral phase coordination in the mammalian circadian timing system. J. Biol. Rhythms24, 3–15 (2009). ArticleCASPubMed Google Scholar
Corradini, I., Verderio, C., Sala, M., Wilson, M. C. & Matteoli, M. SNAP-25 in neuropsychiatric disorders. Ann. N. Y. Acad. Sci.1152, 93–99 (2009). ArticleCASPubMedPubMed Central Google Scholar
Yi, C. X. et al. Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus. Endocrinology147, 283–294 (2006). ArticleCASPubMed Google Scholar
Malek, Z. S., Sage, D., Pevet, P. & Raison, S. Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. Endocrinology148, 5165–5172 (2007). ArticleCASPubMed Google Scholar
Maywood, E. S., O'Neill, J. S., Chesham, J. E. & Hastings, M. H. Minireview: the circadian clockwork of the suprachiasmatic nuclei — analysis of a cellular oscillator that drives endocrine rhythms. Endocrinology148, 5624–5634 (2007). ArticleCASPubMed Google Scholar
Godinho, S. I. et al. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science316, 897–900 (2007). ArticleCASPubMed Google Scholar
Dijk, D. J. & Archer, S. N. PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med. Rev.14, 151–160 (2010). ArticlePubMed Google Scholar